Search Results - "Harries, L W"

Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion by Locke, J. M., da Silva Xavier, G., Dawe, H. R., Rutter, G. A., Harries, L. W.

“…Aims/hypothesis Type 2 diabetes is characterised by progressive beta cell dysfunction, with changes in gene expression playing a crucial role in its…”
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An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes by Locke, J. M., Da Silva Xavier, G., Rutter, G. A., Harries, L. W.

“…Aims/hypothesis Intronic single nucleotide polymorphisms within the transcription factor 7-like 2 ( TCF7L2 ) gene are associated with risk of type 2 diabetes…”
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Messenger RNA processing and its role in diabetes by Harries, L. W.

“…Diabet. Med. 28, 1010–1017 (2011) The past few years have seen huge advances in our understanding of the genetics of diabetes. However, definition of the…”
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Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young by Ellard, S, Thomas, K, Edghill, E. L, Owens, M, Ambye, L, Cropper, J, Little, J, Strachan, M, Stride, A, Ersoy, B, Eiberg, H, Pedersen, O, Shepherd, M. H, Hansen, T, Harries, L. W, Hattersley, A. T

“…Aims/hypothesis Heterozygous mutations of glucokinase (GCK) and hepatocyte nuclear factor-1 alpha (HNF1A; also known as hepatic transcription factor 1 [TCF1])…”
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The position of premature termination codons in the hepatocyte nuclear factor -1 beta gene determines susceptibility to nonsense-mediated decay by HARRIES, L. W, BINGHAM, Coralie, BELLANNE-CHANTELOT, Christine, HATTERSLEY, A. T, ELLARD, Sian

“…The nonsense-mediated decay (NMD) pathway is an mRNA surveillance mechanism that detects and degrades transcripts containing premature termination codons. The…”
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Severe Intrauterine Growth Retardation and Atypical Diabetes Associated with a Translocation Breakpoint Disrupting Regulation of the Insulin-Like Growth Factor 2 Gene by Murphy, R., Baptista, J., Holly, J., Umpleby, A. M., Ellard, S., Harries, L. W., Crolla, J., Cundy, T., Hattersley, A. T.

“…Context: IGF-II is an imprinted gene (predominantly transcribed from the paternally inherited allele), which has an important role in fetal growth in mice…”
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Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer by HARRIES, L. W, STUBBINS, M. J, FORMAN, D, HOWARD, G. C. W, WOLF, C. R

“…Two variant glutathione S-transferase cDNAs have been described at the GSTP1 locus, which differ by a single base pair (A-G) substitution at nucleotide 313 of…”
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Reduced peripheral blood mitochondrial DNA content is not a risk factor for Type 2 diabetes by Singh, R., Hattersley, A. T., Harries, L. W.

“…Aims  Mitochondrial depletion in pancreatic beta cells is known to reduce glucose stimulated insulin secretion. We aimed to determine whether the offspring of…”
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Novel monogenic diabetes mutations in the P2 promoter of the HNF4A gene are associated with impaired function in vitro by Wirsing, A., Johnstone, K. A., Harries, L. W., Ellard, S., Ryffel, G. U., Stanik, J., Gasperikova, D., Klimes, I., Murphy, R.

“…Diabet. Med. 27, 631–635 (2010) Aims  Mutations in HNF4A cause a form of monogenic β‐cell diabetes. We aimed to identify mutations in the pancreas‐specific P2…”
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Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk by RYBERG, D, SKAUG, V, HEWER, A, PHILLIPS, D. H, HARRIES, L. W, WOLF, C. R, ØGREID, D, ULVIK, A, VU, P, HAUGEN, A

“…The A-G polymorphism at codon 104 in the glutathione S-transferase P1 (GSTP1) gene was examined in 138 male lung cancer patients and 297 healthy controls. The…”
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Abnormal splicing of hepatocyte nuclear factor-1 beta in the renal cysts and diabetes syndrome by HARRIES, L. W, ELLARD, S, JONES, R. W. A, HATTERSLEY, A. T, BINGHAM, C

“…Mutations in the hepatocyte nuclear factor-1 beta ( HNF-1 beta) gene result in disorders of renal development, typically involving renal cysts and early-onset…”
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Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation by Lee, B. P., Smith, M., Buffenstein, R., Harries, L. W.

“…Naked mole-rats (NMRs) have amongst the longest lifespans relative to body size of any known, non-volant mammalian species. They also display an enhanced…”
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The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-βH1 cells by Jeffery, N., Richardson, S., Beall, C., Harries, L.W.

“…Interaction between islet cell subtypes and the extracellular matrix influences beta-cell function in mammals. The tissue architecture of rodent islets is very…”
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Variants in the isoform-specific coding regions of the HNF1A, HNF4A and HNF1B genes are not a common cause of familial, young-onset diabetes or renal cysts and diabetes (RCAD) by Locke, J. M., Ellard, S., Norwood, V. F., Harries, L. W.

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Molecular genetics of the human cytochrome P450 monooxygenase superfamily by SMITH, G., STUBBINS, M. J., HARRIES, L. W., WOLF, C. R.

“…Cytochrome P450 genes (P450s) encode a multigene superfamily of mixed-function monooxygenases responsible for the phase I oxidative metabolism of a wide range…”
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Analysis of haematopoietic chimaerism by quantitative real-time polymerase chain reaction by HARRIES, L. W, WICKHAM, C. L, EVANS, J. C, RULE, S. A, JOYNER, M. V, ELLARD, S

“…Allogeneic bone marrow transplantation (BMT) with marrow ablative conditioning is the treatment of choice for haematopoietic malignancies. The use of…”
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Genomics and successful aging: grounds for renewed optimism? by Pilling, L C, Harries, L W, Powell, J, Llewellyn, D J, Ferrucci, L, Melzer, D

“…Successful aging depends in part on delaying age-related disease onsets until later in life. Conditions including coronary artery disease, Alzheimer's disease,…”
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Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons by Pilling, L C, Joehanes, R, Kacprowski, T, Peters, M, Jansen, R, Karasik, D, Kiel, D P, Harries, L W, Teumer, A, Powell, J, Levy, D, Lin, H, Lunetta, K, Munson, P, Bandinelli, S, Henley, W, Hernandez, D, Singleton, A, Tanaka, T, van Grootheest, G, Hofman, A, Uitterlinden, A G, Biffar, R, Gläser, S, Homuth, G, Malsch, C, Völker, U, Penninx, B, van Meurs, J B J, Ferrucci, L, Kocher, T, Murabito, J, Melzer, D

“…Lower muscle strength in midlife predicts disability and mortality in later life. Blood-borne factors, including growth differentiation factor 11 (GDF11), have…”
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Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young by BULMAN, M. P, HARRIES, L. W, HANSEN, T, SHEPHERD, M, KELLY, W. F, HATTERSLEY, A. T, ELLARD, S

“…Mutations in the HNF-1 alpha gene result in maturity-onset diabetes of the young (MODY); an early-onset, dominantly inherited form of diabetes caused by…”
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Erratum to: An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes by Locke, J. M., Da Silva Xavier, G., Rutter, G. A., Harries, L. W.

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