Search Results - "Harried, Scott"

Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine by Horne, Daniel B, Biswas, Kaustav, Brown, James, Bartberger, Michael D, Clarine, Jeffrey, Davis, Carl D, Gore, Vijay K, Harried, Scott, Horner, Michelle, Kaller, Matthew R, Lehto, Sonya G, Liu, Qingyian, Ma, Vu V, Monenschein, Holger, Nguyen, Thomas T, Yuan, Chester C, Youngblood, Beth D, Zhang, Maosheng, Zhong, Wenge, Allen, Jennifer R, Chen, Jian Jeffrey, Gavva, Narender R

“…Transient-receptor-potential melastatin 8 (TRPM8), the predominant mammalian cold-temperature thermosensor, is a nonselective cation channel expressed in a…”
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Extracellular Antibody Drug Conjugates Exploiting the Proximity of Two Proteins by Marshall, David J, Harried, Scott S, Murphy, John L, Hall, Chad A, Shekhani, Mohammed S, Pain, Christophe, Lyons, Conner A, Chillemi, Antonella, Malavasi, Fabio, Pearce, Homer L, Thorson, Jon S, Prudent, James R

“…The human Na+/K+-ATPase (NKA) is a plasma membrane ion pump that uses ATP to help maintain the resting potential of all human cells. Inhibition of the NKA…”
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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid by Weiss, Matthew M, Williamson, Toni, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dineen, Thomas A, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, Rattan, Claire, San Miguel, Tisha, Sickmier, E.Allen, Wahl, Robert C, Wen, Paul H, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

“…A series of potent hydroxyethyl amine (HEA) derived inhibitors of β-site APP cleaving enzyme (BACE1) was optimized to address suboptimal pharmacokinetics and…”
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Unified Total Synthesis of Pteriatoxins and Their Diastereomers by Matsuura, Fumiyoshi, Peters, René, Anada, Masahiro, Harried, Scott S, Hao, Junliang, Kishi, Yoshito

“…A unified total synthesis is reported to access all of the possible diastereomers of pteriatoxins A−C, with the use of an intramolecular Diels−Alder reaction…”
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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors by Dineen, Thomas A, Weiss, Matthew M, Williamson, Toni, Acton, Paul, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dunn, Robert T, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, San Miguel, Tisha, Sickmier, E. Allen, Vargas, Hugo M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

“…We have previously shown that hydroxyethylamines can be potent inhibitors of the BACE1 enzyme and that the generation of BACE1 inhibitors with CYP 3A4…”
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Stereoselective Synthesis of anti-N-Protected 3-Amino-1,2-epoxides by Nucleophilic Addition to N-tert-Butanesulfinyl Imine of a Glyceraldehyde Synthon by Harried, Scott S, Croghan, Michael D, Kaller, Matthew R, Lopez, Patricia, Zhong, Wenge, Hungate, Randall, Reider, Paul J

“…A di-O-TBS protected glyceraldehyde synthon was condensed with Ellman’s reagent to form a bench-stable N-tert-butanesulfinyl imine 6, which served as a common…”
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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase by Kaller, Matthew R, Harried, Scott S, Albrecht, Brian, Amarante, Patricia, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Brown, Ryan, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Graceffa, Russell, Hickman, Dean, Judd, Ted, Kriemen, Chuck, La, Daniel, Li, Vivian, Lopez, Patricia, Luo, Yi, Masse, Craig, Monenschein, Holger, Nguyen, Thomas, Pennington, Lewis D, Miguel, Tisha San, Sickmier, E. Allen, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, Williamson, Toni, Wood, Stephen, Xue, May, Yang, Bryant, Zhang, Jianhua, Patel, Vinod, Zhong, Wenge, Hitchcock, Stephen

“…β-Secretase inhibitors are potentially disease-modifying treatments for Alzheimer's disease. Previous efforts in our laboratory have resulted in…”
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Total Synthesis of the Potent Microtubule-Stabilizing Agent (+)-Discodermolide by Harried, Scott S, Lee, Christopher P, Yang, Ge, Lee, Tony I. H, Myles, David C

“…The total synthesis of the potent microtubule-stabilizing, antimitotic agent (+)-discodermolide is described. The convergent synthetic strategy takes advantage…”
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Total Synthesis of (−)-Discodermolide:  An Application of a Chelation-Controlled Alkylation Reaction by Harried, Scott S, Yang, Ge, Strawn, Marcus A, Myles, David C

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Abstract 1202: Target identification for a new type of ADC by Prudent, James R., Hall, Chad, Marshall, David J., Harried, Scott, Murphy, John

“…Abstract Purpose: To explore the mechanism of action of a potent new type of antibody drug conjugate (ADC) called Extracellular Drug Conjugates or EDCs…”
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Abstract A125: Antibody targeted steroids for the treatment of cancer by Prudent, James R., Marshall, David, Murphy, John, Hall, Chad, Harried, Scott

“…Abstract Purpose: The cardiac glycoside family of steroidal drugs has been shown to possess novel and potent antitumor activities in rodents. Yet most likely…”
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Abstract 2964: An anti-CD20 extracellular antibody-drug conjugate for the treatment of B-cell malignancies by Prudent, James R., Hall, Chad A., Marshall, David J., Murphy, John, Harried, Scott

“…Abstract Purpose: CD20 is known to be a therapeutic antibody drug target as it is expressed on the surface of most B-cell neoplasms. Here, we assessed the…”
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An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities by Cheng, Yuan, Brown, James, Judd, Ted C, Lopez, Patricia, Qian, Wenyuan, Powers, Timothy S, Chen, Jian Jeffrey, Bartberger, Michael D, Chen, Kui, Dunn, Robert T, Epstein, Oleg, Fremeau, Robert T, Harried, Scott, Hickman, Dean, Hitchcock, Stephen A, Luo, Yi, Minatti, Ana Elena, Patel, Vinod F, Vargas, Hugo M, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, White, Ryan D, Whittington, Douglas A, Zheng, Xiao Mei, Wood, Stephen

“…BACE1 inhibition to prevent Aβ peptide formation is considered to be a potential route to a disease-modifying treatment for Alzheimer’s disease. Previous…”
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Discrete layers of ordered fullerene C60 molecules in the cocrystal C60.cntdot.CH2I2.cntdot.C6H6: synthesis, crystal structure, and carbon-13 NMR properties by Geiser, Urs, Kumar, S. Kalyan, Savall, Bradley M, Harried, Scott S, Carlson, K. D, Mobley, Paul R, Wang, H. Hau, Williams, Jack M, Botto, Robert E

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A total synthesis of (-)-discodermolide by Harried, Scott S

“…The potent microtubule-stabilizing agent discodermolide is a polypropionate-derived marine natural product with antitumor activity similar to that of taxol. A…”
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