Search Results - "Harrap, Kenneth R."

Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV) : an orally active platinum drug by KELLAND, L. R, ABEL, G, MCKEAGE, M. J, JONES, M, GODDARD, P. M, VALENTI, M, MURRER, B. A, HARRAP, K. R

“…The cytotoxicity of a novel platinum(IV) complex, bis-acetato-amminedichloro-cyclohexylamine platinum(IV) (JM216), has been evaluated in vitro against a panel…”
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A novel trans-platinum coordination complex possessing in vitro and in vivo antitumor activity by KELLAND, L. R, BARNARD, C. F. J, MELLISH, K. J, JONES, M, GODDARD, P. M, VALENTI, M, BRYANT, A, MURRER, B. A, HARRAP, K. R

“…As part of a drug discovery program to discover more effective platinum-based anticancer drugs, a series of platinum complexes of trans coordination geometry…”
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Ammine/amine platinum(IV) dicarboxylates : a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines by KELLAND, L. R, MURRER, B. A, ABEL, G, GIANDOMENICO, C. M, MISTRY, P, HARRAP, K. R

“…Using a panel of six human ovarian carcinoma cell lines varying by two orders of magnitude in terms of cisplatin cytotoxicity, we have investigated the in…”
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Genomic Imbalances Associated with Acquired Resistance to Platinum Analogues by Leyland-Jones, Brian, Kelland, Lloyd R., Harrap, Kenneth R., Hiorns, Lynne R.

“…During the past several years, a panel of human tumor cell lines (predominantly ovarian) with acquired resistance to cisplatin, the orally bioavailable…”
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Establishment and characterization of an in vitro model of acquired resistance to cisplatin in a human testicular nonseminomatous germ cell line by KELLAND, L. R, MISTRY, P, ABEL, G, FREIDLOS, F, LOH, S. Y, ROBERTS, J. J, HARRAP, K. R

“…Clinically, human testicular nonseminomatous germ cell tumors exhibit remarkable sensitivity to platinum-based chemotherapy. To define better the mechanistic…”
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Schedule dependency of orally administered bis-acetato-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) in vivo by MCKEAGE, J. M, KELLAND, L. R, BOXALL, F. E, VALENTI, M. R, JONES, M, GODDARD, P. M, GWYNNE, J, HARRAP, K. R

“…JM216 is a novel antitumor platinum(IV) complex displaying oral activity, dose-limiting myelosuppression, and a lack of nephro- and neurotoxicity in rodents…”
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Lack of neurotoxicity of oral bisacetatoamminedichlorocyclohexylamine-platinum(IV) in comparison to cisplatin and tetraplatin in the rat by MCKEAGE, M. J, BOXALL, F. E, JONES, M, HARRAP, K. R

“…This study compared the effect on sensory nerve conduction velocity in the hind limb of chronically treated age-matched rats of a novel lipophilic p.o…”
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Pharmacokinetics of cis-diammine-1,1-cyclobutane dicarboxylate platinum(II) in patients with normal and impaired renal function by HARLAND, S. J, NEWELL, D. R, SIDDIK, Z. H, CHADWICK, R, CALVERT, A. H, HARRAP, K. R

“…cis-Diammine-1,1-cyclobutane dicarboxylate platinum(II) (CBDCA, JM8) is a nonnephrotoxic analogue of cisplatin currently undergoing clinical evaluation…”
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The comparative pharmacokinetics of carboplatin and cisplatin in mice and rats by Siddik, Z H, Newell, D R, Boxall, F E, Harrap, K R

“…The plasma, urinary and biliary clearances of cisplatin and its non-nephrotoxic analogue, Carboplatin (cis-diammine-1,1-cyclobutane dicarboxylate platinum II,…”
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Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives by Serafinowski, Pawel, Dorland, Erwin, Harrap, Kenneth R, Balzarini, Jan, De Clercq, Erik

“…A series of new S-adenosyl-L-homocysteine (AdoHcy) analogues with modifications to amino acid and nucleoside moieties was prepared via condensation of…”
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Flameless atomic absorption spectrophotometric determination of platinum in tissues solubilized in hyamine hydroxide by Siddik, Z H, Boxall, F E, Harrap, K R

“…Processing biological samples by solubilization in Hyamine hydroxide (methylbenzethonium hydroxide) as an alternative to wet ashing with concentrated nitric…”
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Dinucleotide analogs as inhibitors of thymidine kinase, thymidylate kinase and ribonucleotide reductase by Davies, Lawrence C, Stock, John A, Barrie, S. Elaine, Orr, Rosanne M, Harrap, Kenneth R

“…P1-(Adenosine-5')-Pn-(thymidine-5') tri-, tetra-, penta-, and hexaphosphates (ApnT) plus the analogues with a methylene group alpha, beta to the thymidine…”
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Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications by Jones, Terence R, Smithers, Michael J, Taylor, Michael A, Jackman, Ann L, Calvert, A. Hilary, Harland, Stephen J, Harrap, Kenneth R

“…Four new analogues of the antifolate N10-propargyl-5,8-dideazafolic acid were prepared that were substituted in the benzoyl ring. The 2'-chloro and 2'-methyl…”
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Quinazoline antifolates inhibiting thymidylate synthase. Variation of the amino acid by Jones, Terence R, Smithers, Michael J, Betteridge, Richard F, Taylor, Michael A, Jackman, Ann L, Calvert, A. Hilary, Davies, Lawrence C, Harrap, Kenneth R

“…Five new analogues (1c-g) of the antifolate N10-propargyl-5,8-dideazafolic acid (1a) are described in which the benzoyl-L-glutamate moiety was replaced by…”
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Enhancement of the nuclear reactivity of alkylating agents by prednisolone by Wilkinson, R, Birbeck, M S, Harrap, K R

“…We have compared the nuclear reactions of the alkylating agents chlorambucil, melphalan, and cyclophosphamide used alone, with those produced when the same…”
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A reappraisal of the effect upon thymidine kinase of thymidine derivatives carrying large groups at the 5'-position by Barrie, S. Elaine, Davies, Lawrence C, Stock, John A, Harrap, Kenneth R

“…Several thymidine derivatives with hydrophobic 5'-substituents, linked by chemically stable amide and ether links, were synthesized as potential thymidine…”
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Selectivity of action of alkylating agents and drug resistance. 4. Synthesis of tritium-labeled chlorambucil and a study of its cellular uptake by drug-sensitive and drug-resistant strains of the Yoshida ascites sarcoma in vitro by Hill, Bridget T, Jarman, Michael, Harrap, Kenneth R

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Synthesis and in Vitro and in Vivo Antitumor Activity of a Series of Trans Platinum Antitumor Complexes by Kelland, Lloyd R, Barnard, F. J, Evans, Iona G, Murrer, Barry A, Theobald, Brian R. C, Wyer, Sandra B, Goddard, Phyllis M, Jones, Mervyn, Valenti, Melanie

“…The synthesis of a series of platinum complexes of trans coordination geometry [centered around the general formula,…”
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cis-Diamminedichloroplatinum(II)-induced cell death through apoptosis in sensitive and resistant human ovarian carcinoma cell lines by ORMEROD, M. G, O'NEILL, C, ROBERTSON, D, KELLAND, L. R, HARRAP, K. R

“…We have studied the effects of the chemotherapeutic drug cis-diamminedichloroplatinum(II) (cis-platin) on three human ovarian carcinoma cell lines - one…”
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A phase I and pharmacology study of an oral platinum complex, JM216 : dose-dependent pharmacokinetics with single-dose administration by MCKEAGE, M. J, PRAKASH MISTRY, SANTABARBARA, P, HARRAP, K. R, JUDSON, I. R, WARD, J, BOXALL, F. E, SWEE LOH, O'NEILL, C, ELLIS, P, KELLAND, L. R, MORGAN, S. E, MURRER, B

“…JM216 [bis-acetato-ammine-dichloro-cyclo-hexylamine-platinum (IV)] is an oral platinum complex with in vivo activity against murine and human tumor models and…”
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