Search Results - "Harper, Matthew M."

P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition by Vázquez-Rosa, Edwin, Shin, Min-Kyoo, Dhar, Matasha, Chaubey, Kalyani, Cintrón-Pérez, Coral J., Tang, Xinmiao, Liao, Xudong, Miller, Emiko, Koh, Yeojung, Barker, Sarah, Franke, Kathryn, Crosby, Danyel R., Schroeder, Rachel, Emery, Josie, Yin, Terry C., Fujioka, Hisashi, Reynolds, James D., Harper, Matthew M., Jain, Mukesh K., Pieper, Andrew A.

“…Chronic neurodegeneration in survivors of traumatic brain injury (TBI) is a major cause of morbidity, with no effective therapies to mitigate this progressive…”
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Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes by Harper, Matthew M, Grozdanic, Sinisa D, Blits, Bas, Kuehn, Markus H, Zamzow, Daniel, Buss, Janice E, Kardon, Randy H, Sakaguchi, Donald S

“…To evaluate the ability of mesenchymal stem cells (MSCs) engineered to produce and secrete brain-derived neurotrophic factor (BDNF) to protect retinal function…”
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P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury by Yin, Terry C., Britt, Jeremiah K., De Jesús-Cortés, Héctor, Lu, Yuan, Genova, Rachel M., Khan, Michael Z., Voorhees, Jaymie R., Shao, Jianqiang, Katzman, Aaron C., Huntington, Paula J., Wassink, Cassie, McDaniel, Latisha, Newell, Elizabeth A., Dutca, Laura M., Naidoo, Jacinth, Cui, Huxing, Bassuk, Alexander G., Harper, Matthew M., McKnight, Steven L., Ready, Joseph M., Pieper, Andrew A.

“…The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3…”
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Chronic effects of blast injury on the microvasculature in a transgenic mouse model of Alzheimer's disease related Aβ amyloidosis by Clark, Alexander T, Abrahamson, Eric E, Harper, Matthew M, Ikonomovic, Milos D

“…Altered cerebrovascular function and accumulation of amyloid-β (Aβ) after traumatic brain injury (TBI) can contribute to chronic neuropathology and increase…”
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Enhanced attention in rats following blast-induced traumatic brain injury by Navarro, Victor M., Boehme, Nickolas, Wasserman, Edward A., Harper, Matthew M.

“…To evaluate visuo-cognitive sequelae following blast-induced traumatic brain injury in a rat model. Rats were randomly assigned to one of four groups depending…”
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Effect of diet-induced obesity or type 1 or type 2 diabetes on corneal nerves and peripheral neuropathy in C57Bl/6J mice by Yorek, Matthew S., Obrosov, Alexander, Shevalye, Hanna, Holmes, Amey, Harper, Matthew M., Kardon, Randy H., Yorek, Mark A.

“…We determined the impact diet‐induced obesity (DIO) and types 1 and 2 diabetes have on peripheral neuropathy with emphasis on corneal nerve structural changes…”
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Effect of glycemic control on corneal nerves and peripheral neuropathy in streptozotocin-induced diabetic C57Bl/6J mice by Yorek, Matthew S., Obrosov, Alexander, Shevalye, Hanna, Lupachyk, Sergey, Harper, Matthew M., Kardon, Randy H., Yorek, Mark A.

“…We sought to determine the impact that duration of hyperglycemia and control has on corneal nerve fiber density in relation to standard diabetic neuropathy…”
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Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells by Harper, Matthew M., Adamson, Laura, Blits, Bas, Bunge, Mary Bartlett, Grozdanic, Sinisa D., Sakaguchi, Donald S.

“…The purpose of this study was to determine the viability of cell-based delivery of brain-derived neurotrophic factor (BDNF) from genetically modified…”
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Identification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury by Harper, Matthew M., Rudd, Danielle, Meyer, Kacie J., Kanthasamy, Anumantha. G., Anantharam, Vellareddy, Pieper, Andrew A., Vázquez-Rosa, Edwin, Shin, Min-Kyoo, Chaubey, Kalyani, Koh, Yeojung, Evans, Lucy P., Bassuk, Alexander G., Anderson, Michael G., Dutca, Laura, Kudva, Indira T., John, Manohar

“…In addition to needing acute emergency management, blast-mediated traumatic brain injury (TBI) is also a chronic disorder with delayed-onset symptoms that…”
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Functional and Structural Changes in a Canine Model of Hereditary Primary Angle-Closure Glaucoma by Grozdanic, Sinisa D, Kecova, Helga, Harper, Matthew M, Nilaweera, Wijitha, Kuehn, Markus H, Kardon, Randy H

“…To characterize functional and structural changes in a canine model of hereditary primary angle-closure glaucoma. Intraocular pressure (IOP) was evaluated with…”
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Characterization of the Jet-Flow Overpressure Model of Traumatic Brain Injury in Mice by Shin, Min-Kyoo, Vázquez-Rosa, Edwin, Cintrón-Pérez, Coral J, Riegel, William A, Harper, Matthew M, Ritzel, David, Pieper, Andrew A

“…The jet-flow overpressure chamber (OPC) has been previously reported as a model of blast-mediated traumatic brain injury (bTBI). However, rigorous…”
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Increasing the number and intensity of shock tube generated blast waves leads to earlier retinal ganglion cell dysfunction and regional cell death by Harper, Matthew M., Boehme, Nickolas A., Dutca, Laura, Navarro, Victor

“…The purpose of this study was to examine the effect of a blast exposure generated from a shock tube on retinal ganglion cell (RGC) function and structure. Mice…”
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Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury by Mohan, Kabhilan, Kecova, Helga, Hernandez-Merino, Elena, Kardon, Randy H, Harper, Matthew M

“…To evaluate retina and optic nerve damage following experimental blast injury. Healthy adult mice were exposed to an overpressure blast wave using a…”
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Characterization of structure and function of the mouse retina using pattern electroretinography, pupil light reflex, and optical coherence tomography by Mohan, Kabhilan, Harper, Matthew M., Kecova, Helga, Ye, Eun-Ah, Lazic, Tatjana, Sakaguchi, Donald S., Kardon, Randy H., Grozdanic, Sinisa D.

“…Objective  To perform in vivo analysis of retinal functional and structural parameters in healthy mouse eyes. Animal Studied  Adult C57BL/6 male mice (n = 37)…”
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The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent by Harper, Matthew M., Boehme, Nickolas, Dutca, Laura M., Anderson, Michael G.

“…PurposeThe purpose of this study was to examine the influence of genetic background on the retinal ganglion cell (RGC) response to blast-mediated traumatic…”
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Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes by Shevalye, Hanna, Yorek, Matthew S, Coppey, Lawrence J, Holmes, Amey, Harper, Matthew M, Kardon, Randy H, Yorek, Mark A

“…The purpose of this study was to determine the effect of supplementing the diet of a mouse model of type 2 diabetes with menhaden (fish) oil or daily treatment…”
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Author response: Pressure wave dosimetry for "Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury" by Harper, Matthew M

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Immune responses in mice after blast-mediated traumatic brain injury TBI autonomously contribute to retinal ganglion cell dysfunction and death by Harper, Matthew M., Gramlich, Oliver W., Elwood, Benjamin W., Boehme, Nickolas A., Dutca, Laura M., Kuehn, Markus H.

“…The purpose of this study was to examine the role of the immune system and its influence on chronic retinal ganglion cell (RGC) dysfunction following…”
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Decreased Expression of Glial-Derived Neurotrophic Factor Receptors in Glaucomatous Human Retinas by Akurathi, Abhigna, Boese, Erin A., Kardon, Randy H., Ledolter, Johannes, Kuehn, Markus H., Harper, Matthew M.

“…The purpose of this study was to examine the expression of glial-derived neurotrophic factor (GDNF), the GDNF receptors GFRα1 and GFRα2, ciliary neurotrophic…”
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Modulation of Post-Traumatic Immune Response Using the IL-1 Receptor Antagonist Anakinra for Improved Visual Outcomes by Evans, Lucy P, Woll, Addison W, Wu, Shu, Todd, Brittany P, Hehr, Nicole, Hedberg-Buenz, Adam, Anderson, Michael G, Newell, Elizabeth A, Ferguson, Polly J, Mahajan, Vinit B, Harper, Matthew M, Bassuk, Alexander G

“…The purpose of this study was to characterize acute changes in inflammatory pathways in the mouse eye after blast-mediated traumatic brain injury (bTBI) and to…”
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