Search Results - "Harper, Kristin N."

Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity by Feder, Alison F, Harper, Kristin N, Brumme, Chanson J, Pennings, Pleuni S

“…Triple-drug therapies have transformed HIV from a fatal condition to a chronic one. These therapies should prevent HIV drug resistance evolution, because one…”
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Batch Effects and Pathway Analysis: Two Potential Perils in Cancer Studies Involving DNA Methylation Array Analysis by HARPER, Kristin N, PETERS, Brandilyn A, GAMBLE, Mary V

“…DNA methylation microarrays have become an increasingly popular means of studying the role of epigenetics in cancer, although the methods used to analyze these…”
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Treponemal infection in nonhuman primates as possible reservoir for human yaws by Knauf, Sascha, Liu, Hsi, Harper, Kristin N

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Genomics, the origins of agriculture, and our changing microbe-scape: Time to revisit some old tales and tell some new ones by Harper, Kristin N., Armelagos, George J.

“…ABSTRACT Though agriculture is often viewed as one of humanity's crowning achievements, skeletal evidence indicates that dependence on domesticated plants and…”
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Whole genome sequence of the Treponema pallidum subsp. endemicum strain Iraq B: A subpopulation of bejel treponemes contains full-length tprF and tprG genes similar to those present in T. p. subsp. pertenue strains by Mikalová, Lenka, Janečková, Klára, Nováková, Markéta, Strouhal, Michal, Čejková, Darina, Harper, Kristin N, Šmajs, David

“…Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). Until now, only a single TEN strain, Bosnia A, has been…”
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The origin and antiquity of syphilis revisited: An Appraisal of Old World pre-Columbian evidence for treponemal infection by Harper, Kristin N., Zuckerman, Molly K., Harper, Megan L., Kingston, John D., Armelagos, George J.

“…For nearly 500 years, scholars have argued about the origin and antiquity of syphilis. Did Columbus bring the disease from the New World to the Old World? Or…”
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Chronic arsenic exposure and blood glutathione and glutathione disulfide concentrations in Bangladeshi adults by Hall, Megan N, Niedzwiecki, Megan, Liu, Xinhua, Harper, Kristin N, Alam, Shafiul, Slavkovich, Vesna, Ilievski, Vesna, Levy, Diane, Siddique, Abu B, Parvez, Faruque, Mey, Jacob L, van Geen, Alexander, Graziano, Joseph, Gamble, Mary V

“…In vitro and rodent studies have shown that arsenic (As) exposure can deplete glutathione (GSH) and induce oxidative stress. GSH is the primary intracellular…”
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Treponema pallidum infection in the wild baboons of East Africa: distribution and genetic characterization of the strains responsible by Harper, Kristin N, Fyumagwa, Robert D, Hoare, Richard, Wambura, Philemon N, Coppenhaver, Dorian H, Sapolsky, Robert M, Alberts, Susan C, Tung, Jenny, Rogers, Jeffrey, Kilewo, Morris, Batamuzi, Emmanuel K, Leendertz, Fabian H, Armelagos, George J, Knauf, Sascha

“…It has been known for decades that wild baboons are naturally infected with Treponema pallidum, the bacterium that causes the diseases syphilis (subsp…”
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Best practices in the African Medicines Regulatory Harmonization initiative: Perspectives of regulators and medicines manufacturers by Ndomondo-Sigonda, Margareth, Azatyan, Samvel, Doerr, Petra, Agaba, Collins, Harper, Kristin N

“…In the African Medicines Regulatory Harmonization initiative, national regulatory authorities (NRAs) within each of Africa's regional economic communities…”
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On the origin of the treponematoses: a phylogenetic approach by Harper, Kristin N, Ocampo, Paolo S, Steiner, Bret M, George, Robert W, Silverman, Michael S, Bolotin, Shelly, Pillay, Allan, Saunders, Nigel J, Armelagos, George J

“…Since the first recorded epidemic of syphilis in 1495, controversy has surrounded the origins of the bacterium Treponema pallidum subsp. pallidum and its…”
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A dose-response study of arsenic exposure and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults by Niedzwiecki, Megan M, Hall, Megan N, Liu, Xinhua, Oka, Julie, Harper, Kristin N, Slavkovich, Vesna, Ilievski, Vesna, Levy, Diane, van Geen, Alexander, Mey, Jacob L, Alam, Shafiul, Siddique, Abu B, Parvez, Faruque, Graziano, Joseph H, Gamble, Mary V

“…Several studies employing cell culture and animal models have suggested that arsenic (As) exposure induces global DNA hypomethylation. However, As has been…”
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The Science Behind Pre-Columbian Evidence of Syphilis in Europe: Research by Documentary by Armelagos, George J., Zuckerman, Molly K., Harper, Kristin N.

“…This article discusses the presentation of scientific findings by documentary, without the process of peer review. We use, as an example, PBS's “The Syphilis…”
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HVTN100 phase 1/2 vaccine trial results promising; phase 2b/3 trial to commence by Harper, Kristin N

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New research on using CRISPR/Cas9 to treat HIV by Harper, Kristin N

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Conference on Retroviruses and Opportunistic Infections 2017 highlights by Harper, Kristin N

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A decade of learning about the HIV reservoir: new insights into latent infection by Harper, Kristin N

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HIV-altered gut microbiome may be driving disease progression by Harper, Kristin N

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Antibody therapy paired with antiretroviral therapy suppresses viral load long term in SIV+ macaques, even after treatment stops by Harper, Kristin N

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To break patent or not to break patent: what is in the best interests of HIV patients in low-income countries? by Harper, Kristin N

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New mouse models provide insights into how to design a more effective HIV vaccine by Harper, Kristin N

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