Search Results - "Harper, G.S"

Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation by Ranjbar, Jacob, Yang, Ying, Harper, Alan G.S.

“…Thrombus formation is highly dependent upon the physico-chemical environment in which it is triggered. Our ability to understand how thrombus formation is…”
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Effects of dietary factors and other metabolic modifiers on quality and nutritional value of meat by Dunshea, F.R., D’Souza, D.N., Pethick, D.W., Harper, G.S., Warner, R.D.

“…A number of technologies that increase feed efficiency and lean tissue deposition while decreasing fat deposition have been developed in an effort to improve…”
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Effects of vitamin A on growth performance and carcass quality in steers by Kruk, Z.A., Bottema, C.D.K., Davis, J.J., Siebert, B.D., Harper, G.S., Di, J., Pitchford, W.S.

“…Vitamin A plays a critical role in many essential life processes. In herbivores, it is either derived from plant β-carotene or directly as a dietary…”
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Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeleton by Cauwenberghs, Sandra, Feijge, Marion A.H., Harper, Alan G.S., Sage, Stewart O., Curvers, Joyce, Heemskerk, Johan W.M.

“…Platelet activation by potent, Ca 2+-mobilizing agonists results in shedding of microparticles that are active in coagulation. Here we show that platelets…”
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A role for hTRPC1 and lipid raft domains in store-mediated calcium entry in human platelets by Brownlow, Sharon L, Harper, Alan G.S, Harper, Matthew T, Sage, Stewart O

“…We have previously suggested that store-mediated Ca 2+ entry (SMCE) in human platelets may be activated by a secretion-like coupling model, involving de novo…”
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Dual role of tubulin-cytoskeleton in store-operated calcium entry in human platelets by Redondo, Pedro C., Harper, Alan G.S., Sage, Stewart O., Rosado, Juan A.

“…Two mechanisms for store-operated Ca2+ entry (SOCE) regulated by two independent Ca2+ stores, the dense tubular system (DTS) and the acidic stores, have been…”
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Two Pathways for Store-mediated Calcium Entry Differentially Dependent on the Actin Cytoskeleton in Human Platelets by Rosado, Juan A, López, José J, Harper, Alan G S, Harper, Matthew T, Redondo, Pedro C, Pariente, José A, Sage, Stewart O, Salido, Ginés M

“…A major pathway for stimulated Ca 2+ entry in non-excitable cells is activated following depletion of intracellular Ca 2+ stores. Secretion-like coupling…”
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Conventional protein kinase C isoforms differentially regulate ADP- and thrombin-evoked Ca2+ signalling in human platelets by Lever, Robert A, Hussain, Azhar, Sun, Benjamin B, Sage, Stewart O, Harper, Alan G.S

“…Graphical abstract…”
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Effect of growth path on the tenderness of the semitendinosus muscle of Brahman-cross steers by Allingham, P.G., Harper, G.S., Hunter, R.A.

“…The growth paths of 36, nine-month-old Brahman-cross steers were modified to determine the effect of their growth history on tenderness of the semitendinosus…”
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A key role for reverse Na+ /Ca2+ exchange influenced by the actin cytoskeleton in store-operated Ca2+ entry in human platelets: Evidence against the de novo conformational coupling hypothesis by Harper, Alan G.S, Sage, Stewart O

“…Abstract We have previously demonstrated a role for the reorganization of the actin cytoskeleton in store-operated calcium entry (SOCE) in human platelets and…”
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A key role for dense granule secretion in potentiation of the Ca2+ signal arising from store-operated calcium entry in human platelets by Harper, Alan G.S, Mason, Michael J, Sage, Stewart O

“…Abstract Recent work has demonstrated a role for Na+ /Ca2+ exchange in potentiation of the Ca2+ entry elicited through the human platelet store-operated…”
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A role for the intracellular protease calpain in the activation of store-operated calcium entry in human platelets by Harper, Alan G.S, Sage, Stewart O

“…Abstract Here, we report a novel role for the cysteine protease calpain in store-operated calcium entry. Several structurally and mechanistically unrelated…”
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Gene expression profiling of bovine skeletal muscle in response to and during recovery from chronic and severe undernutrition by Lehnert, S.A, Byrne, K.A, Reverter, A, Nattrass, G.S, Greenwood, P.L, Wang, Y.H, Hudson, N.J, Harper, G.S

“…Gene expression profiles of LM from beef cattle that underwent significant postweaning undernutrition were studied using complementary DNA (cDNA) microarrays…”
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Human platelets use a cytosolic Ca2+ nanodomain to activate Ca2+-dependent shape change independently of platelet aggregation by Anand, Peterson, Harper, Alan G.S.

“…[Display omitted] •Human platelets possess a Ca2+ nanodomain resistant to dimethyl-BAPTA loading.•Ca2+ rises in the nanodomain trigger Ca2+-dependent shape…”
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Bovine myofiber characteristics are influenced by postweaning nutrition by Greenwood, P.L, Tomkins, N.W, Hunter, R.A, Allingham, P.G, Harden, S, Harper, G.S

“…This study determined the extent to which bovine longissimus lumborum muscle (LLM) myofibers are influenced by nutrition for 120 d from weaning and the…”
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Clot‐targeted magnetic hyperthermia permeabilizes blood clots to make them more susceptible to thrombolysis by Cabrera, David, Eizadi Sharifabad, Maneea, Ranjbar, Jacob A., Telling, Neil D., Harper, Alan G. S.

“…Background Thrombolysis is a frontline treatment for stroke, which involves the application of tissue plasminogen activator (tPA) to trigger endogenous…”
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Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine by Sage, Stewart O., Harper, Alan G.S.

“…•The pH gradient across acidic organelles is regulated upon human platelet activation.•Autocrine 5-HT signalling triggers alkalinisation of platelet acidic…”
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Gene expression profiling of muscle tissue in Brahman steers during nutritional restriction by Byrne, K.A, Wang, Y.H, Lehnert, S.A, Harper, G.S, McWillian, S.M, Bruce, H.L, Reverter, A

“…Expression profiling using microarrays allows for the detailed characterization of the gene networks that regulate an animal's response to environmental…”
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Removing cross-cultural barriers to participation in the ISTH Congress by Amigo, Mary-Carmen, Mesquita Camelo, Ricardo, Douketis, James, Lee, Lai Heng, Muia, Joshua, Nagao, Azusa, Scarlatescu, Ecaterina, Harper, Alan G.S.

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Controlling human platelet activation with calcium-binding nanoparticles by Cabrera, David, Walker, Karen, Moise, Sandhya, Telling, Neil D., Harper, Alan G. S.

“…Human platelets aggregate at sites of blood vessel damage in response to a rise in their cytosolic calcium concentration. Controlling these cytosolic calcium…”
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