Search Results - "Harper, Bart"

Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder by Edmondson, Scott D, Zhu, Cheng, Kar, Nam Fung, Di Salvo, Jerry, Nagabukuro, Hiroshi, Sacre-Salem, Beatrice, Dingley, Karen, Berger, Richard, Goble, Stephen D, Morriello, Gregori, Harper, Bart, Moyes, Christopher R, Shen, Dong-Ming, Wang, Liping, Ball, Richard, Fitzmaurice, Aileen, Frenkl, Tara, Gichuru, Loise N, Ha, Sookhee, Hurley, Amanda L, Jochnowitz, Nina, Levorse, Dorothy, Mistry, Shruty, Miller, Randy R, Ormes, James, Salituro, Gino M, Sanfiz, Anthony, Stevenson, Andra S, Villa, Katherine, Zamlynny, Beata, Green, Stuart, Struthers, Mary, Weber, Ann E

“…The discovery of vibegron, a potent and selective human β3-AR agonist for the treatment of overactive bladder (OAB), is described. An early-generation clinical…”
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Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder by Harper, Bart H., Wang, Liping, Zhu, Cheng, Kar, Nam F., Li, Bing, Moyes, Christopher R., Goble, Stephen D., Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda, Li, Xiaofang, Miller, Randy R., Nagabukuro, Hiroshi, Salituro, Gino M., Smith, Sean, Struthers, Mary, Hale, Jeffrey J., Edmondson, Scott D., Berger, Richard

“…[Display omitted] The synthesis of a novel class of piperazine benzamide (reverse amides) targeting the human β3-adrenergic receptor for the treatment of…”
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Investigation of piperazine benzamides as human β 3 adrenergic receptor agonists for the treatment of overactive bladder by Harper, Bart H, Wang, Liping, Zhu, Cheng, Kar, Nam F, Li, Bing, Moyes, Christopher R, Goble, Stephen D, Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N, Hurley, Amanda, Li, Xiaofang, Miller, Randy R, Nagabukuro, Hiroshi, Salituro, Gino M, Smith, Sean, Struthers, Mary, Hale, Jeffrey J, Edmondson, Scott D, Berger, Richard

“…The synthesis of a novel class of piperazine benzamide (reverse amides) targeting the human β -adrenergic receptor for the treatment of overactive bladder…”
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Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder by Moyes, Christopher R, Berger, Richard, Goble, Stephen D, Harper, Bart, Shen, Dong-Ming, Wang, Liping, Bansal, Alka, Brown, Patricia N, Chen, Airu S, Dingley, Karen H, Di Salvo, Jerry, Fitzmaurice, Aileen, Gichuru, Loise N, Hurley, Amanda L, Jochnowitz, Nina, Miller, Randall R, Mistry, Shruty, Nagabukuro, Hiroshi, Salituro, Gino M, Sanfiz, Anthony, Stevenson, Andra S, Villa, Katherine, Zamlynny, Beata, Struthers, Mary, Weber, Ann E, Edmondson, Scott D

“…A series of conformationally restricted acetanilides were synthesized and evaluated as β3-adrenergic receptor agonists (β3-AR) for the treatment of overactive…”
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Rapid development of two factor IXa inhibitors from hit to lead by Parker, Dann L., Walsh, Shawn, Li, Bing, Kim, Esther, Sharipour, Aurash, Smith, Cameron, Chen, Yi-Heng, Berger, Richard, Harper, Bart, Zhang, Ting, Park, Min, Shu, Min, Wu, Jane, Xu, Jiayi, Dewnani, Sunita, Sherer, Edward C., Hruza, Alan, Reichert, Paul, Geissler, Wayne, Sonatore, Lisa, Ellsworth, Kenneth, Balkovec, James, Greenlee, William, Wood, Harold B.

“…[Display omitted] Two high-throughput screening hits were investigated for SAR against human factor IXa. Both hits feature a benzamide linked to a…”
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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide:  A Selective α-Amino Amide Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes by Edmondson, Scott D, Mastracchio, Anthony, Mathvink, Robert J, He, Jiafang, Harper, Bart, Park, You-Jung, Beconi, Maria, Di Salvo, Jerry, Eiermann, George J, He, Huaibing, Leiting, Barbara, Leone, Joseph F, Levorse, Dorothy A, Lyons, Kathryn, Patel, Reshma A, Patel, Sangita B, Petrov, Aleksandr, Scapin, Giovanna, Shang, Jackie, Roy, Ranabir Sinha, Smith, Aaron, Wu, Joseph K, Xu, Shiyao, Zhu, Bing, Thornberry, Nancy A, Weber, Ann E

“…A series of β-substituted biarylphenylalanine amides were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-4) for the treatment of type…”
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Discovery of Vibegron: A Potent and Selective β 3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder by Edmondson, Scott D., Zhu, Cheng, Kar, Nam Fung, Di Salvo, Jerry, Nagabukuro, Hiroshi, Sacre-Salem, Beatrice, Dingley, Karen, Berger, Richard, Goble, Stephen D., Morriello, Gregori, Harper, Bart, Moyes, Christopher R., Shen, Dong-Ming, Wang, Liping, Ball, Richard, Fitzmaurice, Aileen, Frenkl, Tara, Gichuru, Loise N., Ha, Sookhee, Hurley, Amanda L., Jochnowitz, Nina, Levorse, Dorothy, Mistry, Shruty, Miller, Randy R., Ormes, James, Salituro, Gino M., Sanfiz, Anthony, Stevenson, Andra S., Villa, Katherine, Zamlynny, Beata, Green, Stuart, Struthers, Mary, Weber, Ann E.

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Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β 3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder by Moyes, Christopher R., Berger, Richard, Goble, Stephen D., Harper, Bart, Shen, Dong-Ming, Wang, Liping, Bansal, Alka, Brown, Patricia N., Chen, Airu S., Dingley, Karen H., Di Salvo, Jerry, Fitzmaurice, Aileen, Gichuru, Loise N., Hurley, Amanda L., Jochnowitz, Nina, Miller, Randall R., Mistry, Shruty, Nagabukuro, Hiroshi, Salituro, Gino M., Sanfiz, Anthony, Stevenson, Andra S., Villa, Katherine, Zamlynny, Beata, Struthers, Mary, Weber, Ann E., Edmondson, Scott D.

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2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity by Berger, Richard, Zhu, Cheng, Hansen, Alexa R., Harper, Bart, Chen, Zhesheng, Holt, Tom G., Hubert, James, Lee, Susan J., Pan, Jie, Qian, Su, Reitman, Marc L., Strack, Alison M., Weingarth, Drew T., Wolff, Michael, MacNeil, Douglas J., Weber, Ann E., Edmondson, Scott D.

“…The synthesis and biological profile of imidazole carboxamides of general structure 6 as potent and selective cholecystokinin 1 receptor (CCK1R) agonists are…”
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Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors by Cox, Jason M., Harper, Bart, Mastracchio, Anthony, Leiting, Barbara, Sinha Roy, Ranabir, Patel, Reshma A., Wu, Joseph K., Lyons, Kathryn A., He, Huaibing, Xu, Shiyao, Zhu, Bing, Thornberry, Nancy A., Weber, Ann E., Edmondson, Scott D.

“…Substituted 3-aminopiperidines 3 were evaluated as DPP-4 inhibitors. The inhibitors showed good DPP-4 potency with superb selectivity over other peptidases…”
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Heterocyclic acetamide and benzamide derivatives as potent and selective β3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles by GOBLE, Stephen D, LIPING WANG, HURLEY, Amanda, HRENIUK, Donna, PARMEE, Emma, ROBBINS, Michael, SALITURO, Gino, SANFIZ, Anthony, STRECKFUSS, Eric, WATKINS, Eloisa, WEBER, Ann E, STRUTHERS, Mary, LULU HOWELL, K, EDMONDSON, Scott D, BANSAL, Alka, BERGER, Richard, BROCKUNIER, Linda, DISALVO, Jerry, FEIGHNER, Scott, HARPER, Bart, JIAFANG HE

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Heterocyclic acetamide and benzamide derivatives as potent and selective b sub(3)-adrenergic receptor agonists with improved rodent pharmacokinetic profiles by Goble, Stephen D, Wang, Liping, Howell, KLulu, Bansal, Alka, Berger, Richard, Brockunier, Linda, DiSalvo, Jerry, Feighner, Scott, Harper, Bart, He, Jiafang, Hurley, Amanda, Hreniuk, Donna, Parmee, Emma, Robbins, Michael, Salituro, Gino, Sanfiz, Anthony, Streckfuss, Eric, Watkins, Eloisa, Weber, Ann E, Struthers, Mary, Edmondson, Scott D

“…A series of amide derived b sub(3)-adrenergic receptor (AR) agonists is described. The discovery and optimization of several series of compounds derived from…”
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Heterocyclic acetamide and benzamide derivatives as potent and selective β 3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles by Goble, Stephen D., Wang, Liping, Howell, K. Lulu, Bansal, Alka, Berger, Richard, Brockunier, Linda, DiSalvo, Jerry, Feighner, Scott, Harper, Bart, He, Jiafang, Hurley, Amanda, Hreniuk, Donna, Parmee, Emma, Robbins, Michael, Salituro, Gino, Sanfiz, Anthony, Streckfuss, Eric, Watkins, Eloisa, Weber, Ann E., Struthers, Mary, Edmondson, Scott D.

“…A series of amide derived β 3-adrenergic receptor (AR) agonists is described. The discovery and optimization of several series of compounds derived from 1, is…”
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Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles by Goble, Stephen D, Wang, Liping, Howell, K Lulu, Bansal, Alka, Berger, Richard, Brockunier, Linda, DiSalvo, Jerry, Feighner, Scott, Harper, Bart, He, Jiafang, Hurley, Amanda, Hreniuk, Donna, Parmee, Emma, Robbins, Michael, Salituro, Gino, Sanfiz, Anthony, Streckfuss, Eric, Watkins, Eloisa, Weber, Ann E, Struthers, Mary, Edmondson, Scott D

“…A series of amide derived beta(3)-adrenergic receptor (AR) agonists is described. The discovery and optimization of several series of compounds derived from 1,…”
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