Search Results - "Harp, Joyce"

341-P: Effect of Pitolisant on Glucagon in Human Islets and People with Type 1 Diabetes by DEHN, CLAYTON A., FEIN, MELANIE, HU, JACK, YESILDAG, BURCAK, MAXWELL, ROBERT, HARP, JOYCE B.

“…In 3D human islet microtissues from nondiabetic donors, pitolisant, a histamine 3 receptor antagonist, increased glucagon secretion >3-fold compared to vehicle…”
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Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus by Smith, Alexia G, Sheridan, Patricia A, Harp, Joyce B, Beck, Melinda A

“…Obesity is associated with an impaired immune response, an increased susceptibility to bacterial infection, and a chronic increase in proinflammatory cytokines…”
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A first‐in‐human pharmacodynamic and pharmacokinetic study of a fully human anti‐glucagon receptor monoclonal antibody in normal healthy volunteers by Kostic, Ana, King, Thomas Alexander, Yang, Feng, Chan, Kuo‐Chen, Yancopoulos, George D., Gromada, Jesper, Harp, Joyce B.

“…Aims Glucagon receptor (GCGR) blockers are being investigated as potential therapeutics for type 1 and type 2 diabetes. Here we report the safety,…”
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Glycemic Response and Attainment of A1C Goals Following Newly Initiated Insulin Therapy for Type 2 Diabetes by Nichols, Gregory A, Kimes, Teresa M, Harp, Joyce B, Kou, Tzuyung Doug, Brodovicz, Kimberly G

“…OBJECTIVE: To identify the characteristics associated with glycemic response to newly initiated insulin therapy. RESEARCH DESIGN AND METHODS: We identified…”
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Adipose-Specific Disruption of Signal Transducer and Activator of Transcription 3 Increases Body Weight and Adiposity by Cernkovich, Erin R, Deng, Jianbei, Bond, Michael C, Combs, Terry P, Harp, Joyce B

“…To determine the role of STAT3 in adipose tissue, we used Cre-loxP DNA recombination to create mice with an adipocyte-specific disruption of the STAT3 gene…”
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Why do obese patients not lose more weight when treated with low-calorie diets? A mechanistic perspective by Heymsfield, Steven B, Harp, Joyce B, Reitman, Marc L, Beetsch, Joel W, Schoeller, Dale A, Erondu, Ngozi, Pietrobelli, Angelo

“…Maximal weight loss observed in low-calorie diet (LCD) studies tends to be small, and the mechanisms leading to this low treatment efficacy have not been…”
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Increased Energy Expenditure, Dietary Fat Wasting, and Resistance to Diet-Induced Obesity in Mice Lacking Renin by Takahashi, Nobuyuki, Li, Feng, Hua, Kunjie, Deng, Jianbei, Wang, Chih-Hong, Bowers, Robert R., Bartness, Timothy J., Kim, Hyung-Suk, Harp, Joyce B.

“…An overactive renin-angiotensin system is associated with obesity and the metabolic syndrome. However, the mechanisms behind it are unclear. Cleaving…”
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Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis by Harmon, A W, Harp, J B

“…Flavonoids, polyphenolic compounds that exist widely in plants, inhibit cell proliferation and increase cell differentiation in many cancerous and noncancerous…”
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Obesity in the National Football League by Harp, Joyce B, Hecht, Lindsay

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New insights into inhibitors of adipogenesis by Harp, Joyce B

“…Adipose tissue is a dynamic organ that changes mass throughout life in response to the metabolic needs of the animal. In the past three decades, significant…”
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Early treatment-related changes in diabetes and cardiovascular disease risk markers in first episode psychosis subjects by Graham, Karen A, Cho, Hyunsoon, Brownley, Kimberly A, Harp, Joyce B

“…Abstract Objective To examine prospective changes in cardiovascular disease (CVD) and type-2 diabetes risk factors in young adult first episode psychotic (FEP)…”
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Effect of Olanzapine on Body Composition and Energy Expenditure in Adults With First-Episode Psychosis by Graham, Karen A., Perkins, Diana O., Edwards, Lloyd J., Barrier, Robert C., Lieberman, Jeffrey A., Harp, Joyce B.

“…OBJECTIVE: Weight gain is a commonly observed adverse effect of atypical antipsychotic medications, but associated changes in energy balance and body…”
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Midkine Is an Autocrine Activator of Signal Transducer and Activator of Transcription 3 in 3T3-L1 Cells by Cernkovich, Erin R, Deng, Jianbei, Hua, Kunjie, Harp, Joyce B

“…Mitotic clonal expansion is believed to be necessary for 3T3-L1 adipocyte formation. Signal transducer and activator of transcription 3 (STAT3), a mitogenic…”
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Double-Blind, Placebo-Controlled Investigation of Amantadine for Weight Loss in Subjects Who Gained Weight With Olanzapine by Graham, Karen A., Gu, Hongbin, Lieberman, Jeffrey A., Harp, Joyce B., Perkins, Diana O.

“…OBJECTIVE: This study sought to determine if amantadine affects weight gain in psychiatric patients taking olanzapine. METHOD: Twenty-one adults who had gained…”
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Genistein inhibits CCAAT/enhancer-binding protein beta (C/EBPbeta) activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression by Harmon, Anne W, Patel, Yashomati M, Harp, Joyce B

“…The tyrosine kinase inhibitor genistein inhibits 3T3-L1 adipogenesis when present during the first 72 h of differentiation. In this report, we investigated the…”
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Dietary Weight Loss Decreases Serum Angiotensin-Converting Enzyme Activity in Obese Adults by Harp, Joyce B., Henry, Steven A., DiGirolamo, Mario

“…Objective: To study the effect of dietary weight loss, postural change, and an oral glucose load on serum angiotensin‐converting enzyme (ACE) activity in obese…”
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Activation of Signal Transducer and Activator of Transcription-3 during Proliferative Phases of 3T3-L1 Adipogenesis by Deng, Jianbei, Hua, Kunjie, Lesser, Steven S., Harp, Joyce B.

“…Abstract Signal transducer and activator of transcription-3 (STAT3) is abundantly expressed in preadipocytes and adipocytes, but little is known about its…”
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Protein inhibitor of activated STAT3 inhibits adipogenic gene expression by Deng, Jianbei, Hua, Kunjie, Caveney, Erica J., Takahashi, Nobuyuki, Harp, Joyce B.

“…Protein inhibitor of activated STAT3 (PIAS3), a cytokine-induced repressor of signal transducer and activator of transcription 3 (STAT3) and a modulator of a…”
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Interleukin-4 inhibits platelet-derived growth factor-induced preadipocyte proliferation by Hua, Kunjie, Deng, Jianbei, Harp, Joyce B

“…Interleukin-4 (IL-4) activates STAT6 in 3T3-L1 preadipocytes but its functional role is not known. In this report, we first assessed interleukin-4 receptor α…”
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Role of Janus Kinase/Signal Transducer and Activator of Transcription and Mitogen-activated Protein Kinase Cascades in Angiotensin II- and Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Proliferation by Marrero, Mario B., Schieffer, Bernhard, Li, Bing, Sun, Jimin, Harp, Joyce B., Ling, Brian N.

“…In vascular smooth muscle cells, the induction of early growth response genes involves the Janus kinase (JAK)/signal transducer and activators of transcription…”
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