Search Results - "Harp, Christopher T"

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease by Hunter, Zoe, McCarthy, Derrick P, Yap, Woon Teck, Harp, Christopher T, Getts, Daniel R, Shea, Lonnie D, Miller, Stephen D

“…Targeted immune tolerance is a coveted therapy for the treatment of a variety of autoimmune diseases, as current treatment options often involve nonspecific…”
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High-mobility group box 1 protein (HMGB1) neutralization ameliorates experimental autoimmune encephalomyelitis by Robinson, Andrew P, Caldis, Matthew W, Harp, Christopher T, Goings, Gwendolyn E, Miller, Stephen D

“…Abstract Multiple sclerosis (MS) is an autoimmune, demyelinating disease and as such, the gold standard of treatment is to selectively suppress the pathogenic…”
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Rituximab therapy reduces organ-specific T cell responses and ameliorates experimental autoimmune encephalomyelitis by Monson, Nancy L, Cravens, Petra, Hussain, Rehana, Harp, Christopher T, Cummings, Matthew, de Pilar Martin, Maria, Ben, Li-Hong, Do, Julie, Lyons, Jeri-Anne, Lovette-Racke, Amy, Cross, Anne H, Racke, Michael K, Stüve, Olaf, Shlomchik, Mark, Eagar, Todd N

“…Recent clinical trials have established B cell depletion by the anti-CD20 chimeric antibody Rituximab as a beneficial therapy for patients with…”
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The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment by Robinson, Andrew P, Harp, Christopher T, Noronha, Avertano, Miller, Stephen D

“…While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal models are essential in understanding the induction and…”
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An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy by McCarthy, Derrick P., Yap, Jonathan Woon-Teck, Harp, Christopher T., Song, W. Kelsey, Chen, Jeane, Pearson, Ryan M., Miller, Stephen D., Shea, Lonnie D.

“…Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies to treat autoimmune disease. However, many NP-based therapies conjugate…”
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Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells by Getts, Daniel R, Turley, Danielle M, Smith, Cassandra E, Harp, Christopher T, McCarthy, Derrick, Feeney, Emma M, Getts, Meghann Teague, Martin, Aaron J, Luo, Xunrong, Terry, Rachael L, King, Nicholas J C, Miller, Stephen D

“…Ag-specific tolerance is a highly desired therapy for immune-mediated diseases. Intravenous infusion of protein/peptide Ags linked to syngeneic splenic…”
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γδ T cell subsets play opposing roles in regulating experimental autoimmune encephalomyelitis by Blink, Sarah E., Caldis, Matthew W., Goings, Gwendolyn E., Harp, Christopher T., Malissen, Bernard, Prinz, Immo, Xu, Dan, Miller, Stephen D.

“…•γδ IL-17-producing T cells are pathogenic in SJL/J mice with EAE.•A γδ T cells are found in CNS inflammatory lesions and contact oligodendrocytes.•The Vγ4…”
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Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4⁺ T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein by Harp, Christopher T, Ireland, Sara, Davis, Laurie S, Remington, Gina, Cassidy, Bonnie, Cravens, Petra D, Stuve, Olaf, Lovett-Racke, Amy E, Eagar, Todd N, Greenberg, Benjamin M, Racke, Michael K, Cowell, Lindsay G, Karandikar, Nitin J, Frohman, Elliot M, Monson, Nancy L

“…Recent evidence suggests that B- and T-cell interactions may be paramount in relapsing-remitting MS (RRMS) disease pathogenesis. We hypothesized that memory…”
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Cutting Edge: CD99 Is a Novel Therapeutic Target for Control of T Cell-Mediated Central Nervous System Autoimmune Disease by Winger, Ryan C, Harp, Christopher T, Chiang, Ming-Yi, Sullivan, David P, Watson, Richard L, Weber, Evan W, Podojil, Joseph R, Miller, Stephen D, Muller, William A

“…Leukocyte trafficking into the CNS is a prominent feature driving the immunopathogenesis of multiple sclerosis and its animal model, experimental autoimmune…”
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Antibody-independent B cell effector functions in relapsing remitting Multiple Sclerosis: Clues to increased inflammatory and reduced regulatory B cell capacity by Ireland, Sara J., Blazek, Monica, Harp, Christopher T., Greenberg, Benjamin, Frohman, Elliot M., Davis, Laurie S., Monson, Nancy L.

“…The pathogenic role for B cells in the context of relapsing remitting multiple sclerosis (MS) is incompletely defined. Although classically considered a T…”
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Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis by Harp, Christopher T, Lovett-Racke, Amy E, Racke, Michael K, Frohman, Elliot M, Monson, Nancy L

“…Abstract The role of B cells in the pathogenesis of Multiple Sclerosis (MS) is incompletely understood. Here we define a possible role for B cells as…”
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Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis by Cameron, Elizabeth M, Spencer, Sade, Lazarini, Jonathan, Harp, Christopher T, Ward, E. Sally, Burgoon, Mark, Owens, Gregory P, Racke, Michael K, Bennett, Jeffrey L, Frohman, Elliot M, Monson, Nancy L

“…Abstract We identified a unique antibody gene mutation pattern (i.e. “signature”) in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients…”
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Neurofilament Light Chain (NfL) Levels in CSF, Serum, and Plasma of Healthy Donors Using the Quanterix NfL Advantage Kit™ (P1.9-032) by Harp, Christopher T., Hendricks, Robert, Fischer, Sally K., Brumm, Jochen, Herman, Ann H.

“…Abstract only…”
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NfL Levels in CSF, Serum, and Plasma of RRMS and PPMS Patients in a Cross-sectional UCSF Cohort (P2.2-082) by Harp, Christopher T., Ma, Xiaoye, Hendricks, Robert, Fischer, Sally K., Eggers, Erica, Von Budingen, H., Towsend, Michael, Herman, Ann H.

“…Abstract only…”
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Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity by Shinoda, Koji, Li, Rui, Rezk, Ayman, Mexhitaj, Ina, Patterson, Kristina R, Kakara, Mihir, Zuroff, Leah, Bennett, Jeffrey L, von Büdingen, H-Christian, Carruthers, Robert, Edwards, Keith R, Fallis, Robert, Giacomini, Paul S, Greenberg, Benjamin M, Hafler, David A, Ionete, Carolina, Kaunzner, Ulrike W, Lock, Christopher B, Longbrake, Erin E, Pardo, Gabriel, Piehl, Fredrik, Weber, Martin S, Ziemssen, Tjalf, Jacobs, Dina, Gelfand, Jeffrey M, Cross, Anne H, Cameron, Briana, Musch, Bruno, Winger, Ryan C, Jia, Xiaoming, Harp, Christopher T, Herman, Ann, Bar-Or, Amit

“…A small proportion of multiple sclerosis (MS) patients develop new disease activity soon after starting anti-CD20 therapy. This activity does not recur with…”
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CD99 is a novel therapeutic target for control of T-cell mediated CNS autoimmune disease by Winger, Ryan C., Harp, Christopher T., Chiang, Ming-Yi, Sullivan, David P., Watson, Richard L., Weber, Evan W., Podojil, Joseph R., Miller, Stephen D., Muller, William A.

“…Leukocyte trafficking into the central nervous system (CNS) is a prominent feature driving the immunopathogenesis of multiple sclerosis (MS) and its animal…”
Get full text

An antigen-encapsulating nanoparticle platform for TH 1/17 immune tolerance therapy by McCarthy, Derrick P., PhD, Yap, Jonathan Woon-Teck, PhD, Harp, Christopher T., PhD, Song, W. Kelsey, BS, Chen, Jeane, PhD, Pearson, Ryan M., PhD, Miller, Stephen D., PhD, Shea, Lonnie D., PhD

“…Abstract Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies to treat autoimmune disease. However, many NP-based therapies…”
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Contribution of memory and naïve B cells to myelin specific T cell function in relapsing remitting multiple sclerosis (99.8) by Harp, Christopher T, Frohman, Elliot, Monson, Nancy L

“…Abstract B cell depletion therapy reduces numbers of B and T cells within the cerebrospinal fluid (CSF) of relapsing remitting multiple sclerosis (RRMS)…”
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γδ T Cell Subsets Play Opposing Roles in Regulating Experimental Autoimmune Encephalomyelitis1 by Blink, Sarah E., Caldis, Matthew W., Goings, Gwendolyn E., Harp, Christopher T., Malissen, Bernard, Prinz, Immo, Xu, Dan, Miller, Stephen D.

“…γδ T cells are resident in cerebrospinal fluid and central nervous system (CNS) lesions of multiple sclerosis (MS) patients, but as multifaceted cells…”
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An antigen-encapsulating nanoparticle platform for T H 1/17 immune tolerance therapy by McCarthy, Derrick P, Yap, Jonathan Woon-Teck, Harp, Christopher T, Song, W Kelsey, Chen, Jeane, Pearson, Ryan M, Miller, Stephen D, Shea, Lonnie D

“…Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies to treat autoimmune disease. However, many NP-based therapies conjugate…”
Get full text