Search Results - "Harouki, Najah"

Vascular Smooth Muscle Mineralocorticoid Receptor Contributes to Coronary and Left Ventricular Dysfunction After Myocardial Infarction by Gueret, Alexandre, Harouki, Najah, Favre, Julie, Galmiche, Guillaume, Nicol, Lionel, Henry, Jean-Paul, Besnier, Marie, Thuillez, Christian, Richard, Vincent, Kolkhof, Peter, Mulder, Paul, Jaisser, Frédéric, Ouvrard-Pascaud, Antoine

“…Mineralocorticoid receptor (MR) antagonists slow down the progression of heart failure after myocardial infarction (MI), but the cell-specific role of MR in…”
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Sympathetic Nerve Activity and Baroreflex are Strongly Altered in a Context of Severe Hypertension Using the Spontaneously Hypertensive Rat Model Associated with Chronic Reduction of Nitric Oxide by Vayssettes-Courchay, Christine, Melka, Jonathan, Philouze, Clothilde, Harouki, Najah

“…The aim of our study is to investigate the sympathetic output and baroreflex via renal sympathetic nerve activity (RSNA) recording in a model of severe…”
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The IL-1β Antibody Gevokizumab Limits Cardiac Remodeling and Coronary Dysfunction in Rats With Heart Failure by Harouki, Najah, BS, Nicol, Lionel, PhD, Remy-Jouet, Isabelle, PhD, Henry, Jean-Paul, BS, Dumesnil, Anais, BS, Lejeune, Annie, BS, Renet, Sylvanie, BS, Golding, Francesca, BS, Djerada, Zoubir, PhD, Wecker, Didier, PhD, Bolduc, Virginie, PhD, Bouly, Muriel, PhD, Roussel, Jerome, PhD, Richard, Vincent, PhD, Mulder, Paul, PhD

“…Visual Abstract…”
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Mineralocorticoid receptor blockade with finerenone improves heart function and exercise capacity in ovariectomized mice by Pieronne‐Deperrois, Marie, Guéret, Alexandre, Djerada, Zoubir, Crochemore, Clément, Harouki, Najah, Henry, Jean‐Paul, Dumesnil, Anaïs, Larchevêque, Marine, Rego, Jean‐Claude, Rego, Jean‐Luc, Nicol, Lionel, Richard, Vincent, Jaisser, Frédéric, Kolkhof, Peter, Mulder, Paul, Monteil, Christelle, Ouvrard‐Pascaud, Antoine

“…Aims In post‐menopausal women, incidence of heart failure with preserved ejection fraction is higher than in men. Hormonal replacement therapies did not…”
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Transient heart rate reduction improves acute decompensated heart failure‐induced left ventricular and coronary dysfunction by Peschanski, Nicolas, Harouki, Najah, Soulie, Matthieu, Lachaux, Marianne, Nicol, Lionel, Remy‐Jouet, Isabelle, Henry, Jean‐Paul, Dumesnil, Anais, Renet, Sylvanie, Fougerousse, Françoise, Brakenhielm, Ebba, Ouvrard‐Pascaud, Antoine, Thuillez, Christian, Richard, Vincent, Roussel, Jérôme, Mulder, Paul

“…Aims Acute decompensated heart failure (ADHF), a live‐threatening complication of heart failure (HF), associates a further decrease of the already by…”
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Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice by Roche, Clothilde, Besnier, Marie, Cassel, Roméo, Harouki, Najah, Coquerel, David, Guerrot, Dominique, Nicol, Lionel, Loizon, Emmanuelle, Remy-Jouet, Isabelle, Morisseau, Christophe, Mulder, Paul, Ouvrard-Pascaud, Antoine, Madec, Anne-Marie, Richard, Vincent, Bellien, Jeremy

“…This study addressed the hypothesis that inhibiting the soluble epoxide hydrolase (sEH)-mediated degradation of epoxy-fatty acids, notably epoxyeicosatrienoic…”
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Nitrogen Dioxide Inhalation Exposures Induce Cardiac Mitochondrial Reactive Oxygen Species Production, Impair Mitochondrial Function and Promote Coronary Endothelial Dysfunction by Karoui, Ahmed, Crochemore, Clément, Harouki, Najah, Corbière, Cécile, Preterre, David, Vendeville, Cathy, Richard, Vincent, Fardel, Olivier, Lecureur, Valérie, Vaugeois, Jean-Marie, Sichel, François, Mulder, Paul, Monteil, Christelle

“…Traffic air pollution is a major health problem and is recognized as an important risk factor for cardiovascular (CV) diseases. In a previous experimental…”
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Infliximab improves endothelial dysfunction in a mouse model of antiphospholipid syndrome: Role of reduced oxidative stress by Benhamou, Ygal, Miranda, Sébastien, Armengol, Guillaume, Harouki, Najah, Drouot, Laurent, Zahr, Noel, Thuillez, Christian, Boyer, Olivier, Levesque, Hervé, Joannides, Robinson, Richard, Vincent

“…Abstract Antiphospholipid syndrome (APS), induces endothelial dysfunction, oxidative stress and systemic inflammation that may be mediated by TNFα. Thus, we…”
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Impact of soluble epoxide hydrolase inhibition on early kidney damage in hyperglycemic overweight mice by Roche, Clothilde, Guerrot, Dominique, Harouki, Najah, Duflot, Thomas, Besnier, Marie, Rémy-Jouet, Isabelle, Renet, Sylvanie, Dumesnil, Anaïs, Lejeune, Annie, Morisseau, Christophe, Richard, Vincent, Bellien, Jeremy

“…•This study shows that sEH inhibition prevents the development of renal dysfunction in hyperglycemic overweight mice beyond its hypoglycemic effect.•sEH…”
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Abstract CT133: A phase 1b multicenter study of anti-TIM3 (S095018/Sym023) in combination with anti-PD1 (Sym021) in patients with advanced/metastatic recurrent biliary tract cancer by Ghiringhelli, Francois, Kim, Richard, Macarulla, Teresa, Moreno, Irene, Razak, Albiruni, Rodon, Jordi, Liao, Chih-Yi, Marron, Thomas, Raimbourg, Judith, Kaplon, Helene, Geromini, Julia, Harouki, Najah, Rodrigues, Christelle, Darcel, Pauline, Skartved, Niels Jorgen, Hald, Rikke, Lopez-Ravnborg, Daleen, He, Peng, Ianopoulos, Xenophon, Askoxylakis, Vasileios, Lakhani, Nehal J., Davis, Sarah, Mahipal, Amit

“…Abstract Background: TIM3 is an inhibitory immunoreceptor linked to decreased activity of immune cells in the tumor microenvironment. S095018 is a human…”
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Abstract 3737: Molecular and early clinical characterization of the anti-CD73 antibody S095024 (Sym024) by Spreafico, Anna, Ahnert, Jordi R., Sommerhalder, David, Almena-Carrasco, Maria, Crochemore, Najah Harouki, Ianopulos, Xenophon, Jakobsen, Janus S., Armbruster, Emily, Delmas, Audrey, Georges, Amédée des, Fröhlich, Camilla, Geronimi, Julia, Grandal, Michael M., Hansen, Randi W., Lantto, Johan, Legrand, Julie, Levasseur, Franck, Riva, Matteo, Rodrigues, Christelle, Seif, Vanessa, Askoxylakis, Vasileios, Lakhani, Nehal

“…Abstract Background: Adenosine signaling is a central immunosuppressive mechanism affecting a broad set of immune cell types. Adenosine is generated from…”
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Improvement of left ventricular diastolic function induced by β-blockade: a comparison between nebivolol and metoprolol by Fang, Yuehua, Nicol, Lionel, Harouki, Najah, Monteil, Christelle, Wecker, Didier, Debunne, Manuelle, Bauer, Fabrice, Lallemand, Françoise, Richard, Vincent, Thuillez, Christian, Mulder, Paul

“…Enhanced adrenergic drive is involved in the development of left ventricular (LV) diastolic dysfunction observed in metabolic syndrome (MS). Thus, β-blockers…”
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Improvement of left ventricular diastolic function induced by β-blockade by Fang, Yuehua, Nicol, Lionel, Harouki, Najah, Monteil, Christelle, Wecker, Didier, Debunne, Manuelle, Bauer, Fabrice, Lallemand, Françoise, Richard, Vincent, Thuillez, Christian, Mulder, Paul

“…Abstract Objectives Enhanced adrenergic drive is involved in the development of left ventricular (LV) diastolic dysfunction observed in metabolic syndrome…”
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0378 : Time course of cardiac dysfunction in experimental acute decompensation of chronic heart failure by Lachaux, Marianne, Peschanski, Nicolas, Harouki, Najah, Henry, Jean-Paul, Nicol, Lionel, Brakenhielm, Ebba, Ouvrard-Pascaud, Antoine, Richard, Vincent, Thuillez, Chrsitian, Mulder, Paul

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0542 : Vascular smooth muscle mineralocorticoid receptor contributes to coronary and left ventricular dysfunction after myocardial infarction by Gueret, Alexandre, Harouki, Najah, Favre, Julie, Galmiche, Guillaume, Nicol, Lionel, Henry, Jean-Paul, Thuillez, Christian, Richard, Vincent, Kolkhof, Peter, Mulder, Paul, Ouvrard-Pascaud, Antoine, Jaisser, Frédéric

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0316 : Vascular smooth muscle mineralocorticoid receptor contributes to coronary and left ventricular dysfunction after myocardial infarction by Gueret, Alexandre, Harouki, Najah, Galmiche, Guillaume, Favre, J., Nicol, Lionel, Henry, Jean Paul, Besnier, M., Thuillez, Christian, Richard, Vincent, Kolkhof, P., Mulder, Paul, Jaisser, Frédéric, Ouvrard-Pascaud, Antoine

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0190: Early and delayed IL-1 beta antibody gevokizumab treatments prevent cardiac remodeling and reverse coronary endothelial dysfunction following myocardial infarction injury in Goto Kakizaki rats by Harouki, Najah, Nicol, Lionel, Henry, Jean-Paul, Richard, Vincent, Bolduc, Virginie, Roussel, Jérôme, Mulder, Paul, Thuillez, Christian

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0213: Gevokizumab, an IL1-beta modulating antibody exerts promising cardioprotective effects against ischemia-reperfusion injury in diabetic rats by Harouki, Najah, Nicol, Lionel, Merabet, Nassiba, Henry, Jean-Paul, Gluais, Pascale, Richard, Vincent, Roussel, Jérôme, Thuillez, Christian, Mulder, Paul

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Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice has No Major Impact on Cardiac Collagen and Function Under Basal Conditions by Sansilvestri-Morel, Patricia, Harouki-Crochemore, Najah, Bertin, Florence, Bertheux, Hélène, Vermeil de Conchard, Guy, Diguet, Nicolas, Desfosses, Emilie, Lecomte, Mathilde, Gonzalez, Arantxa, Diez, Javier, Tupinon-Mathieu, Isabelle, Delerive, Philippe

“…Maturation of fibrillar collagen is known to play a crucial role in the pathophysiology of myocardial fibrosis. Procollagen C-proteinase enhancer 1 (PCPE1) has…”
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DEFICIENCY OF PROCOLLAGEN C-PROTEINASE ENHANCER 1 (PCPE1) IN MICE HAS NO MAJOR IMPACT ON CARDIAC COLLAGEN AND FUNCTION UNDER BASAL CONDITIONS by Sansilvestri-Morel, Patricia, Harouki-Crochemore, Najah, bertin, Florence, Bertheux, Hélène, De Conchard, Guy Vermeil, Diguet, Nicolas, Desfosses, Emilie, Lecomte, Mathilde, Gonzalez, Arantxa, Diez, Javier, Tupinon-Mathieu, Isabelle, Delerive, Philippe

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