Search Results - "Harold F. Sims"

High-fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress by Moon, Sung Ho, Dilthey, Beverly Gibson, Liu, Xinping, Guan, Shaoping, Sims, Harold F., Gross, Richard W.

“…High-fat (HF) diet–induced obesity precipitates multiple metabolic disorders including insulin resistance, glucose intolerance, oxidative stress, and…”
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Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways by Liu, Xinping, Moon, Sung Ho, Jenkins, Christopher M, Sims, Harold F, Gross, Richard W

“…Eicosanoid lipids play important roles in cellular signaling as second messengers in inflammation, immune response, vascular tone, and the CNS. Biosynthesis of…”
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Synthesis of oxidized phospholipids by sn-1 acyltransferase using 2–15-HETE lysophospholipids by Liu, Gao-Yuan, Moon, Sung Ho, Jenkins, Christopher M., Sims, Harold F., Guan, Shaoping, Gross, Richard W.

“…Recently, oxidized phospholipid species have emerged as important signaling lipids in activated immune cells and platelets. The canonical pathway for the…”
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Identification, Cloning, Expression, and Purification of Three Novel Human Calcium-independent Phospholipase A2 Family Members Possessing Triacylglycerol Lipase and Acylglycerol Transacylase Activities by Jenkins, Christopher M, Mancuso, David J, Yan, Wei, Sims, Harold F, Gibson, Beverly, Gross, Richard W

“…Genetic knockout of hormone-sensitive lipase in mice has implicated the presence of other intracellular triacylglycerol (TAG) lipases mediating TAG hydrolysis…”
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Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome[S] by Kiebish, Michael A., Yang, Kui, Liu, Xinping, Mancuso, David J., Guan, Shaoping, Zhao, Zhongdan, Sims, Harold F., Cerqua, Rebekah, Cade, W. Todd, Han, Xianlin, Gross, Richard W.

“…Barth syndrome is a complex metabolic disorder caused by mutations in the mitochondrial transacylase tafazzin. Recently, an inducible tafazzin shRNA knockdown…”
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Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation by Liu, Xinping, Moon, Sung Ho, Mancuso, David J., Jenkins, Christopher M., Guan, Shaoping, Sims, Harold F., Gross, Richard W.

“…A highly sensitive, specific, and robust method for the analysis of oxidized metabolites of linoleic acid (LA), arachidonic acid (AA), and docosahexaenoic acid…”
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A Fetal Fatty-Acid Oxidation Disorder as a Cause of Liver Disease in Pregnant Women by Ibdah, Jamal A, Bennett, Michael J, Rinaldo, Piero, Zhao, Yiwen, Gibson, Beverly, Sims, Harold F, Strauss, Arnold W

“…Acute fatty liver of pregnancy is a devastating disorder associated with substantial maternal and neonatal morbidity and mortality. 1 – 4 The HELLP syndrome…”
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12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2γ knockout by Liu, Xinping, Sims, Harold F., Jenkins, Christopher M., Guan, Shaoping, Dilthey, Beverly G., Gross, Richard W.

“…The canonical pathway of eicosanoid production in most mammalian cells is initiated by phospholipase A2-mediated release of arachidonic acid, followed by its…”
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Reversible high affinity inhibition of phosphofructokinase-1 by acyl-CoA: a mechanism integrating glycolytic flux with lipid metabolism by Jenkins, Christopher M, Yang, Jingyue, Sims, Harold F, Gross, Richard W

“…The enzyme phosphofructokinase-1 (PFK-1) catalyzes the first committed step of glycolysis and is regulated by a complex array of allosteric effectors that…”
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A functional role for eicosanoid-lysophospholipids in activating monocyte signaling by Liu, Gao-Yuan, Moon, Sung Ho, Jenkins, Christopher M., Sims, Harold F., Guan, Shaoping, Gross, Richard W.

“…Recently, eicosanoid-lysophospholipids were identified as novel metabolites generated from the direct cyclooxygenase- or lipoxygenase-catalyzed oxidation of…”
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Molecular heterogeneity in very-long-chain acyl-CoA dehydrogenase deficiency causing pediatric cardiomyopathy and sudden death by MATHUR, A, SIMS, H. F, GOPALAKRISHNAN, D, GIBSON, B, RINALDO, P, VOCKLEY, J, HUG, G, STRAUSS, A. W

“…Genetic defects are being increasingly recognized in the etiology of primary cardiomyopathy (CM). Very-long-chain acyl-CoA dehydrogenase (VLCAD) catalyzes the…”
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Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A2γ (iPLA2γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size by Moon, Sung Ho, Mancuso, David J., Sims, Harold F., Liu, Xinping, Nguyen, Annie L., Yang, Kui, Guan, Shaoping, Dilthey, Beverly Gibson, Jenkins, Christopher M., Weinheimer, Carla J., Kovacs, Attila, Abendschein, Dana, Gross, Richard W.

“…Calcium-independent phospholipase A2γ (iPLA2γ) is a mitochondrial enzyme that produces lipid second messengers that facilitate opening of the mitochondrial…”
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The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling by Liu, Gao-Yuan, Moon, Sung Ho, Jenkins, Christopher M., Li, Maoyin, Sims, Harold F., Guan, Shaoping, Gross, Richard W.

“…Cardiolipin (CL) is a dimeric phospholipid with critical roles in mitochondrial bioenergetics and signaling. Recently, inhibition of the release of oxidized…”
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Genetic Ablation of Calcium-independent Phospholipase A2γ Prevents Obesity and Insulin Resistance during High Fat Feeding by Mitochondrial Uncoupling and Increased Adipocyte Fatty Acid Oxidation by Mancuso, David J., Sims, Harold F., Yang, Kui, Kiebish, Michael A., Su, Xiong, Jenkins, Christopher M., Guan, Shaoping, Moon, Sung Ho, Pietka, Terri, Nassir, Fatiha, Schappe, Timothy, Moore, Kristin, Han, Xianlin, Abumrad, Nada A., Gross, Richard W.

“…Phospholipases are critical enzyme mediators participating in many aspects of cellular function through modulating the generation of lipid 2nd messengers,…”
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Genetic Ablation of Calcium-independent Phospholipase A2γ Leads to Alterations in Mitochondrial Lipid Metabolism and Function Resulting in a Deficient Mitochondrial Bioenergetic Phenotype by Mancuso, David J., Sims, Harold F., Han, Xianlin, Jenkins, Christopher M., Guan, Shao Ping, Yang, Kui, Moon, Sung Ho, Pietka, Terri, Abumrad, Nada A., Schlesinger, Paul H., Gross, Richard W.

“…Previously, we identified a novel calcium-independent phospholipase, designated calcium-independent phospholipase A2 γ (iPLA2γ), which possesses dual…”
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Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency by Kiebish, Michael A, Yang, Kui, Sims, Harold F, Jenkins, Christopher M, Liu, Xinping, Mancuso, David J, Zhao, Zhongdan, Guan, Shaoping, Abendschein, Dana R, Han, Xianlin, Gross, Richard W

“…Lipidomic regulation of mitochondrial cardiolipin content and molecular species composition is a prominent regulator of bioenergetic efficiency. However, the…”
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Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism by Moon, Sung Ho, Dilthey, Beverly Gibson, Guan, Shaoping, Sims, Harold F., Pittman, Sara K., Keith, Amy L., Jenkins, Christopher M., Weihl, Conrad C., Gross, Richard W.

“…Skeletal muscle is the major site of glucose utilization in mammals integrating serum glucose clearance with mitochondrial respiration. To mechanistically…”
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Reversible High Affinity Inhibition of Phosphofructokinase-1 by Acyl-CoA by Jenkins, Christopher M., Yang, Jingyue, Sims, Harold F., Gross, Richard W.

“…The enzyme phosphofructokinase-1 (PFK-1) catalyzes the first committed step of glycolysis and is regulated by a complex array of allosteric effectors that…”
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Activation of group VI phospholipase A2 isoforms in cardiac endothelial cells by Sharma, Janhavi, Turk, John, Mancuso, David J, Sims, Harold F, Gross, Richard W, McHowat, Jane

“…The endothelium comprises a cellular barrier between the circulation and tissues. We have previously shown that activation of protease-activated receptor 1…”
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Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release by Moon, Sung Ho, Jenkins, Christopher M, Kiebish, Michael A, Sims, Harold F, Mancuso, David J, Gross, Richard W

“…Herein, we demonstrate that calcium-independent phospholipase A(2)γ (iPLA(2)γ) is a critical mechanistic participant in the calcium-induced opening of the…”
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