Search Results - "Harokopos, Vaggelis"
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Hepatocyte autotaxin expression promotes liver fibrosis and cancer
Published in Hepatology (Baltimore, Md.) (01-04-2017)“…Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the production of lysophosphatidic acid (LPA), a pleiotropic growth‐factor–like…”
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The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Pathogenesis and progression of lung cancer are governed by complex interactions between the environment and host genetic susceptibility, which is further…”
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SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis
Published in Nature communications (21-09-2023)“…The activation and accumulation of lung fibroblasts resulting in aberrant deposition of extracellular matrix components, is a pathogenic hallmark of Idiopathic…”
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Mutant KRAS promotes malignant pleural effusion formation
Published in Nature communications (16-05-2017)“…Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However, the mechanisms responsible for…”
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A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate
Published in Cell reports (Cambridge) (21-06-2016)“…The canonical Wnt pathway plays a central role in stem cell maintenance, differentiation, and proliferation in the intestinal epithelium. Constitutive,…”
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The RNA-Binding Protein Elavl1/HuR Is Essential for Placental Branching Morphogenesis and Embryonic Development
Published in Molecular and Cellular Biology (01-05-2009)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identifying novel regulatory effects for clinically relevant genes through the study of the Greek population
Published in BMC genomics (05-08-2023)“…Expression quantitative trait loci (eQTL) studies provide insights into regulatory mechanisms underlying disease risk. Expanding studies of gene regulation to…”
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The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time
Published in Annals of medicine (Helsinki) (01-09-2010)“…To evaluate the profile of pro- and anti-inflammatory cytokines in type 1 diabetes mellitus (T1DM) and the way they are connected in co-regulated networks and…”
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A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency
Published in mBio (21-12-2021)“…To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected…”
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Soluble TNF mediates the transition from pulmonary inflammation to fibrosis
Published in PloS one (27-12-2006)“…Fibrosis, the replacement of functional tissue with excessive fibrous tissue, can occur in all the main tissues and organ systems, resulting in various…”
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Systems biology reveals key tissue-specific metabolic and transcriptional signatures involved in the response of Medicago truncatula plant genotypes to salt stress
Published in Computational and structural biotechnology journal (01-01-2021)“…[Display omitted] •Τhe response of different Medicago truncatula genotypes to salt stress was examined.•Systems biology revealed tissue-specific metabolic and…”
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Obesity Reshapes the Microbial Population Structure along the Gut-Liver-Lung Axis in Mice
Published in Biomedicines (19-02-2022)“…The microbiome is emerging as a major player in tissue homeostasis in health and disease. Gut microbiome dysbiosis correlates with several autoimmune and…”
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Molecular Epidemiology of SARS-CoV-2 in Greece Reveals Low Rates of Onward Virus Transmission after Lifting of Travel Restrictions Based on Risk Assessment during Summer 2020
Published in mSphere (30-06-2021)“…The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly during the first months of 2020 and continues to expand in…”
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A Critical Role for Gelsolin in Ventilator-Induced Lung Injury
Published in American journal of respiratory cell and molecular biology (01-10-2009)“…Mechanical ventilation, an essential life-support modality of patients with acute lung injury (ALI) or the acute respiratory distress syndrome (ARDS), exerts…”
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Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis
Published in PLoS genetics (01-10-2005)“…Rheumatoid arthritis is a chronic inflammatory disease with a high prevalence and substantial socioeconomic burden. Despite intense research efforts, its…”
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Bee foraging preferences, microbiota and pathogens revealed by direct shotgun metagenomics of honey
Published in Molecular ecology resources (01-10-2022)“…Honeybees (Apis mellifera) continue to succumb to human and environmental pressures despite their crucial role in providing essential ecosystem services. Owing…”
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Kresoxim-methyl primes Medicago truncatula plants against abiotic stress factors via altered reactive oxygen and nitrogen species signalling leading to downstream transcriptional and metabolic readjustment
Published in Journal of experimental botany (01-03-2016)“…Biotic and abiotic stresses, such as fungal infection and drought, cause major yield losses in modern agriculture. Kresoxim-methyl (KM) belongs to the…”
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Mast cells mediate malignant pleural effusion formation
Published in The Journal of clinical investigation (01-06-2015)“…Mast cells (MCs) have been identified in various tumors; however, the role of these cells in tumorigenesis remains controversial. Here, we quantified MCs in…”
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The molecular biology of the olive fly comes of age
Published in BMC genetics (01-12-2014)“…Olive cultivation blends with the history of the Mediterranean countries since ancient times. Even today, activities around the olive tree constitute major…”
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