Search Results - "Harnett, Mark"

Filopodia are a structural substrate for silent synapses in adult neocortex by Vardalaki, Dimitra, Chung, Kwanghun, Harnett, Mark T.

“…Newly generated excitatory synapses in the mammalian cortex lack sufficient AMPA-type glutamate receptors to mediate neurotransmission, resulting in…”
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Dendritic Spines Prevent Synaptic Voltage Clamp by Beaulieu-Laroche, Lou, Harnett, Mark T.

“…Synapses are the fundamental units of information processing in the mammalian brain. Much of our understanding of their functional properties comes from…”
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Somatic and Dendritic Encoding of Spatial Variables in Retrosplenial Cortex Differs during 2D Navigation by Voigts, Jakob, Harnett, Mark T.

“…Active amplification of organized synaptic inputs in dendrites can endow individual neurons with the ability to perform complex computations. However, whether…”
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Rethinking Single Neuron Electrical Compartmentalization: Dendritic Contributions to Network Computation In Vivo by Francioni, Valerio, Harnett, Mark T.

“…•Biophysical studies indicate that dendritic compartmentalization increases the computational power of single neurons.•Recent in vivo imaging work has observed…”
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Potassium Channels Control the Interaction between Active Dendritic Integration Compartments in Layer 5 Cortical Pyramidal Neurons by Harnett, Mark T., Xu, Ning-Long, Magee, Jeffrey C., Williams, Stephen R.

“…Active dendritic synaptic integration enhances the computational power of neurons. Such nonlinear processing generates an object-localization signal in the…”
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Widespread and Highly Correlated Somato-dendritic Activity in Cortical Layer 5 Neurons by Beaulieu-Laroche, Lou, Toloza, Enrique H.S., Brown, Norma J., Harnett, Mark T.

“…Dendritic integration can expand the information-processing capabilities of neurons. However, the recruitment of active dendritic processing in vivo and its…”
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Distribution and function of HCN channels in the apical dendritic tuft of neocortical pyramidal neurons by Harnett, Mark T, Magee, Jeffrey C, Williams, Stephen R

“…The apical tuft is the most remote area of the dendritic tree of neocortical pyramidal neurons. Despite its distal location, the apical dendritic tuft of layer…”
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Enhanced Dendritic Compartmentalization in Human Cortical Neurons by Beaulieu-Laroche, Lou, Toloza, Enrique H.S., van der Goes, Marie-Sophie, Lafourcade, Mathieu, Barnagian, Derrick, Williams, Ziv M., Eskandar, Emad N., Frosch, Matthew P., Cash, Sydney S., Harnett, Mark T.

“…The biophysical features of neurons shape information processing in the brain. Cortical neurons are larger in humans than in other species, but it is unclear…”
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Synaptic amplification by dendritic spines enhances input cooperativity by Harnett, Mark T., Makara, Judit K., Spruston, Nelson, Kath, William L., Magee, Jeffrey C.

“…Dendritic spines operate as high-impedance input structures that amplify local synaptic depolarization to enhance electrical interaction among coactive inputs…”
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Nonlinear dendritic integration of sensory and motor input during an active sensing task by Xu, Ning-long, Harnett, Mark T., Williams, Stephen R., Huber, Daniel, O’Connor, Daniel H., Svoboda, Karel, Magee, Jeffrey C.

“…Recordings from cortical neuron dendrites of head-fixed mice during an object-localization task provide direct evidence that a novel global nonlinearity has a…”
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Reversing behavioural abnormalities in mice exposed to maternal inflammation by Shin Yim, Yeong, Park, Ashley, Berrios, Janet, Lafourcade, Mathieu, Pascual, Leila M., Soares, Natalie, Yeon Kim, Joo, Kim, Sangdoo, Kim, Hyunju, Waisman, Ari, Littman, Dan R., Wickersham, Ian R., Harnett, Mark T., Huh, Jun R., Choi, Gloria B.

“…Viral infection during pregnancy is correlated with increased frequency of neurodevelopmental disorders, and this is studied in mice prenatally subjected to…”
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Representation of visual landmarks in retrosplenial cortex by Fischer, Lukas F, Mojica Soto-Albors, Raul, Buck, Friederike, Harnett, Mark T

“…The process by which visual information is incorporated into the brain's spatial framework to represent landmarks is poorly understood. Studies in humans and…”
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Allometric rules for mammalian cortical layer 5 neuron biophysics by Beaulieu-Laroche, Lou, Brown, Norma J., Hansen, Marissa, Toloza, Enrique H. S., Sharma, Jitendra, Williams, Ziv M., Frosch, Matthew P., Cosgrove, Garth Rees, Cash, Sydney S., Harnett, Mark T.

“…The biophysical properties of neurons are the foundation for computation in the brain. Neuronal size is a key determinant of single neuron input–output…”
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An optimized fluorescent probe for visualizing glutamate neurotransmission by Marvin, Jonathan S, Borghuis, Bart G, Tian, Lin, Cichon, Joseph, Harnett, Mark T, Akerboom, Jasper, Gordus, Andrew, Renninger, Sabine L, Chen, Tsai-Wen, Bargmann, Cornelia I, Orger, Michael B, Schreiter, Eric R, Demb, Jonathan B, Gan, Wen-Biao, Hires, S Andrew, Looger, Loren L

“…A single-wavelength genetically encoded sensor of extracellular glutamate is reported. The sensor—iGluSnFR—is bright and photostable under both one- and…”
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Active dendritic integration and mixed neocortical network representations during an adaptive sensing behavior by Ranganathan, Gayathri N., Apostolides, Pierre F., Harnett, Mark T., Xu, Ning-Long, Druckmann, Shaul, Magee, Jeffrey C.

“…Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate…”
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Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial by Berry-Kravis, Elizabeth M., Harnett, Mark D., Reines, Scott A., Reese, Melody A., Ethridge, Lauren E., Outterson, Abigail H., Michalak, Claire, Furman, Jeremiah, Gurney, Mark E.

“…The goal of this study was to determine whether a phosphodiesterase-4D (PDE4D) allosteric inhibitor (BPN14770) would improve cognitive function and behavioral…”
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An easy-to-assemble, robust, and lightweight drive implant for chronic tetrode recordings in freely moving animals by Voigts, Jakob, Newman, Jonathan P, Wilson, Matthew A, Harnett, Mark T

“…Tetrode arrays are a standard method for neuronal recordings in behaving animals, especially for chronic recordings of many neurons in freely-moving animals…”
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Filopodia are a structural substrate for silent synapses in adult neocortex by Vardalaki, Dimitra, Chung, Kwanghun, Harnett, Mark T.

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Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice by Ding, Weihua, Fischer, Lukas, Chen, Qian, Li, Ziyi, Yang, Liuyue, You, Zerong, Hu, Kun, Wu, Xinbo, Zhou, Xue, Chao, Wei, Hu, Peter, Dagnew, Tewodros Mulugeta, Dubreuil, Daniel M, Wang, Shiyu, Xia, Suyun, Bao, Caroline, Zhu, Shengmei, Chen, Lucy, Wang, Changning, Wainger, Brian, Jin, Peng, Mao, Jianren, Feng, Guoping, Harnett, Mark T, Shen, Shiqian

“…Cortical neural dynamics mediate information processing for the cerebral cortex, which is implicated in fundamental biological processes such as vision and…”
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A dendritic mechanism for balancing synaptic flexibility and stability by Yaeger, Courtney E., Vardalaki, Dimitra, Zhang, Qinrong, Pham, Trang L.D., Brown, Norma J., Ji, Na, Harnett, Mark T.

“…Biological and artificial neural networks learn by modifying synaptic weights, but it is unclear how these systems retain previous knowledge and also acquire…”
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