Search Results - "Harndahl, Mikkel"

NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11 by Lundegaard, Claus, Lamberth, Kasper, Harndahl, Mikkel, Buus, Søren, Lund, Ole, Nielsen, Morten

“…NetMHC-3.0 is trained on a large number of quantitative peptide data using both affinity data from the Immune Epitope Database and Analysis Resource (IEDB) and…”
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Peptide‐MHC class I stability is a better predictor than peptide affinity of CTL immunogenicity by Harndahl, Mikkel, Rasmussen, Michael, Roder, Gustav, Dalgaard Pedersen, Ida, Sørensen, Mikael, Nielsen, Morten, Buus, Søren

“…Efficient presentation of peptide‐MHC class I (pMHC‐I) complexes to immune T cells should benefit from a stable peptide‐MHC‐I interaction. However, it has been…”
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Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire by Ostrov, David A, Grant, Barry J, Pompeu, Yuri A, Sidney, John, Harndahl, Mikkel, Southwood, Scott, Oseroff, Carla, Lu, Shun, Jakoncic, Jean, de Oliveira, Cesar Augusto F, Yang, Lun, Mei, Hu, Shi, Leming, Shabanowitz, Jeffrey, English, A. Michelle, Wriston, Amanda, Lucas, Andrew, Phillips, Elizabeth, Mallal, Simon, Grey, Howard M, Sette, Alessandro, Hunt, Donald F, Buus, Soren, Peters, Bjoern

“…Idiosyncratic adverse drug reactions are unpredictable, dose-independent and potentially life threatening; this makes them a major factor contributing to the…”
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NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and -B locus protein of known sequence by Nielsen, Morten, Lundegaard, Claus, Blicher, Thomas, Lamberth, Kasper, Harndahl, Mikkel, Justesen, Sune, Røder, Gustav, Peters, Bjoern, Sette, Alessandro, Lund, Ole, Buus, Søren

“…Binding of peptides to Major Histocompatibility Complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular…”
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Characterization of pSer129-αSyn Pathology and Neurofilament Light-Chain Release across In Vivo, Ex Vivo, and In Vitro Models of Pre-Formed-Fibril-Induced αSyn Aggregation by Hansen, Maja L, Ambjørn, Malene, Harndahl, Mikkel N, Benned-Jensen, Tau, Fog, Karina, Bjerregaard-Andersen, Kaare, Sotty, Florence

“…Protein aggregation is a predominant feature of many neurodegenerative diseases, including synucleinopathies, which are characterized by cellular inclusions…”
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A community resource benchmarking predictions of peptide binding to MHC-I molecules by Peters, Bjoern, Bui, Huynh-Hoa, Frankild, Sune, Nielson, Morten, Lundegaard, Claus, Kostem, Emrah, Basch, Derek, Lamberth, Kasper, Harndahl, Mikkel, Fleri, Ward, Wilson, Stephen S, Sidney, John, Lund, Ole, Buus, Soren, Sette, Alessandro

“…Recognition of peptides bound to major histocompatibility complex (MHC) class I molecules by T lymphocytes is an essential part of immune surveillance. Each…”
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Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response by Madsen, Caroline B, Petersen, Cecilie, Lavrsen, Kirstine, Harndahl, Mikkel, Buus, Søren, Clausen, Henrik, Pedersen, Anders E, Wandall, Hans H

“…Aberrant glycosylation of mucins and other extracellular proteins is an important event in carcinogenesis and the resulting cancer associated glycans have been…”
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HLA-B57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control by KLOVERPRIS, Henrik N, STRYHN, Anette, BUUS, Soren, GOULDER, Philip, HARNDAHL, Mikkel, VAN DER STOK, Mary, PAYNE, Rebecca P, MATTHEW, Phiiippa C, FABIAN CHEN, RIDDELL, Lynn, WALKER, Bruce D, NDUNG'U, Thumbi

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Differential Clade-Specific HLA-B3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope by MATTHEWS, Philippa C, KOYANAGI, Madoka, AVILA RIOS, Santiago, COLE, David, CARLSON, Jonathan, PAYNE, Rebecca P, OGWU, Anthony, BERE, Alfred, NDUNG'U, Thumbi, GOUNDER, Kamini, FABIAN CHEN, RIDDELL, Lynn, KLØVERPRIS, Henrik N, LUZZI, Graz, SHAPIRO, Roger, BRANDER, Christian, WALKER, Bruce, SEWELL, Andrew K, REYES TERAN, Gustavo, HECKERMAN, David, HUNTER, Eric, BUUS, Soren, TAKIGUCHI, Masafumi, HARNDAHL, Mikkel, GOULDER, Philip J. R, STRYHN, Anette, AKAHOSHI, Tomohiro, GATANAGA, Hiroyuki, OKA, Shinichi, JUAREZ MOLINA, Claudia, VALENZUELA PONCE, Humberto

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CD8+ TCR Bias and Immunodominance in HIV-1 Infection by Kløverpris, Henrik N, McGregor, Reuben, McLaren, James E, Ladell, Kristin, Harndahl, Mikkel, Stryhn, Anette, Carlson, Jonathan M, Koofhethile, Catherine, Gerritsen, Bram, Keşmir, Can, Chen, Fabian, Riddell, Lynn, Luzzi, Graz, Leslie, Alasdair, Walker, Bruce D, Ndung'u, Thumbi, Buus, Søren, Price, David A, Goulder, Philip J

“…Immunodominance describes a phenomenon whereby the immune system consistently targets only a fraction of the available Ag pool derived from a given pathogen…”
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Peptide binding to HLA class I molecules: homogenous, high-throughput screening, and affinity assays by Harndahl, Mikkel, Justesen, Sune, Lamberth, Kasper, Røder, Gustav, Nielsen, Morten, Buus, Søren

“…The Human MHC Project aims at large-scale description of peptide-HLA binding to a wide range of HLA molecules covering all populations of the world and the…”
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HIV Control through a Single Nucleotide on the HLA-B Locus by Kløverpris, Henrik N, Harndahl, Mikkel, Leslie, Alasdair J, Carlson, Jonathan M, Ismail, Nasreen, van der Stok, Mary, Huang, Kuan-Hsiang Gary, Chen, Fabian, Riddell, Lynn, Steyn, Dewald, Goedhals, Dominique, van Vuuren, Cloete, Frater, John, Walker, Bruce D, Carrington, Mary, Ndung'u, Thumbi, Buus, Søren, Goulder, Philip

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A Systematic, Unbiased Mapping of CD8 + and CD4 + T Cell Epitopes in Yellow Fever Vaccinees by Stryhn, Anette, Kongsgaard, Michael, Rasmussen, Michael, Harndahl, Mikkel Nors, Østerbye, Thomas, Bassi, Maria Rosaria, Thybo, Søren, Gabriel, Mette, Hansen, Morten Bagge, Nielsen, Morten, Christensen, Jan Pravsgaard, Randrup Thomsen, Allan, Buus, Soren

“…Examining CD8 and CD4 T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8…”
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HLA-Specific Intracellular Epitope Processing Shapes an Immunodominance Pattern for HLA-B57 That Is Distinct from HLA-B58:01 by Kløverpris, Henrik N, Stryhn, Anette, Harndahl, Mikkel, Payne, Rebecca, Towers, Greg J, Chen, Fabian, Riddell, Lynn, Walker, Bruce D, Ndung'u, Thumbi, Leslie, Alasdair, Buus, Søren, Goulder, Philip

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Human leukocyte antigen (HLA) class I restricted epitope discovery in yellow fewer and dengue viruses: importance of HLA binding strength by Lund, Ole, Nascimento, Eduardo J M, Maciel, Jr, Milton, Nielsen, Morten, Larsen, Mette Voldby, Lundegaard, Claus, Harndahl, Mikkel, Lamberth, Kasper, Buus, Søren, Salmon, Jérôme, August, Thomas J, Marques, Jr, Ernesto T A

“…Epitopes from all available full-length sequences of yellow fever virus (YFV) and dengue fever virus (DENV) restricted by Human Leukocyte Antigen class I…”
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HLA class I binding 9mer peptides from influenza A virus induce CD4 T cell responses by Wang, Mingjun, Larsen, Mette V, Nielsen, Morten, Harndahl, Mikkel, Justesen, Sune, Dziegiel, Morten H, Buus, Søren, Tang, Sheila T, Lund, Ole, Claesson, Mogens H

“…Identification of human leukocyte antigen class I (HLA-I) restricted cytotoxic T cell (CTL) epitopes from influenza virus is of importance for the development…”
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Peptide pool immunization and CD8+ T cell reactivity by Rasmussen, Susanne B, Harndahl, Mikkel N, Stryhn, Anette, Buus, Søren, Claesson, Mogens H

“…Highlights ► Peptide pool immunization masks readout of individual peptide specific responses ex vivo . ► Peptide immunization induces peptide-specific…”
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Pan-Specific Prediction of Peptide-MHC Class I Complex Stability, a Correlate of T Cell Immunogenicity by Rasmussen, Michael, Fenoy, Emilio, Harndahl, Mikkel, Kristensen, Anne Bregnballe, Nielsen, Ida Kallehauge, Nielsen, Morten, Buus, Søren

“…Binding of peptides to MHC class I (MHC-I) molecules is the most selective event in the processing and presentation of Ags to CTL, and insights into the…”
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Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule by Rasmussen, Michael, Harndahl, Mikkel, Stryhn, Anette, Boucherma, Rachid, Nielsen, Lise Lotte, Lemonnier, François A, Nielsen, Morten, Buus, Søren

“…MHC class I molecules (HLA-I in humans) present peptides derived from endogenous proteins to CTLs. Whereas the peptide-binding specificities of HLA-A and -B…”
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Real-time, high-throughput measurements of peptide–MHC-I dissociation using a scintillation proximity assay by Harndahl, Mikkel, Rasmussen, Michael, Roder, Gustav, Buus, Søren

“…Efficient presentation of peptide–MHC class I complexes to immune T cells depends upon stable peptide–MHC class I interactions. Theoretically, determining the…”
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