Search Results - "Harms, W"

IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis by Johnston, Andrew, PhD, Xing, Xianying, PhD, Wolterink, Liza, BS, Barnes, Drew H., BS, Yin, ZhiQiang, MD, PhD, Reingold, Laura, BS, Kahlenberg, J. Michelle, MD, PhD, Harms, Paul W., MD, PhD, Gudjonsson, Johann E., MD, PhD

“…Background Generalized pustular psoriasis (GPP) is a rare, debilitating, and often life-threatening inflammatory disease characterized by episodic infiltration…”
Get full text

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities by Harms, Paul W., Harms, Kelly L., Moore, Patrick S., DeCaprio, James A., Nghiem, Paul, Wong, Michael K. K., Brownell, Isaac

“…Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer associated with advanced age and immunosuppression. Over the past decade, an association has…”
Get full text

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression by Lin, Heng, Wei, Shuang, Hurt, Elaine M, Green, Michael D, Zhao, Lili, Vatan, Linda, Szeliga, Wojciech, Herbst, Ronald, Harms, Paul W, Fecher, Leslie A, Vats, Pankaj, Chinnaiyan, Arul M, Lao, Christopher D, Lawrence, Theodore S, Wicha, Max, Hamanishi, Junzo, Mandai, Masaki, Kryczek, Ilona, Zou, Weiping

“…Programmed death-1 receptor (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1) pathway blockade is a promising therapy for treating cancer. However, the…”
Get full text

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins by Quadros, Rolen M, Miura, Hiromi, Harms, Donald W, Akatsuka, Hisako, Sato, Takehito, Aida, Tomomi, Redder, Ronald, Richardson, Guy P, Inagaki, Yutaka, Sakai, Daisuke, Buckley, Shannon M, Seshacharyulu, Parthasarathy, Batra, Surinder K, Behlke, Mark A, Zeiner, Sarah A, Jacobi, Ashley M, Izu, Yayoi, Thoreson, Wallace B, Urness, Lisa D, Mansour, Suzanne L, Ohtsuka, Masato, Gurumurthy, Channabasavaiah B

“…Conditional knockout mice and transgenic mice expressing recombinases, reporters, and inducible transcriptional activators are key for many genetic studies and…”
Get full text

Update on Merkel Cell Carcinoma by Harms, Paul W., MD, PhD

“…Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine malignancy. Merkel cell polyomavirus, a tumorigenic DNA virus, is present in most…”
Get full text

Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin by Jiang, Yanyun, Tsoi, Lam C, Billi, Allison C, Ward, Nicole L, Harms, Paul W, Zeng, Chang, Maverakis, Emanual, Kahlenberg, J Michelle, Gudjonsson, Johann E

“…The skin serves as the primary interface between our body and the external environment and acts as a barrier against entry of physical agents, chemicals, and…”
Get full text

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression by Lin, Heng, Wei, Shuang, Hurt, Elaine M, Green, Michael D, Zhao, Lili, Vatan, Linda, Szeliga, Wojciech, Herbst, Ronald, Harms, Paul W, Fecher, Leslie A, Vats, Pankaj, Chinnaiyan, Arul M, Lao, Christopher D, Lawrence, Theodore S, Wicha, Max, Hamanishi, Junzo, Mandai, Masaki, Kryczek, Ilona, Zou, Weiping

Get full text

Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis by Ma, Feiyang, Plazyo, Olesya, Billi, Allison C., Tsoi, Lam C., Xing, Xianying, Wasikowski, Rachael, Gharaee-Kermani, Mehrnaz, Hile, Grace, Jiang, Yanyun, Harms, Paul W., Xing, Enze, Kirma, Joseph, Xi, Jingyue, Hsu, Jer-En, Sarkar, Mrinal K., Chung, Yutein, Di Domizio, Jeremy, Gilliet, Michel, Ward, Nicole L., Maverakis, Emanual, Klechevsky, Eynav, Voorhees, John J., Elder, James T., Lee, Jun Hee, Kahlenberg, J. Michelle, Pellegrini, Matteo, Modlin, Robert L., Gudjonsson, Johann E.

“…The immunopathogenesis of psoriasis, a common chronic inflammatory disease of the skin, is incompletely understood. Here we demonstrate, using a combination of…”
Get full text

EWSR1-NFATC2 Translocation-associated Sarcoma Clinicopathologic Findings in a Rare Aggressive Primary Bone or Soft Tissue Tumor by Wang, Grace Y, Thomas, Dafydd G, Davis, Jessica L, Ng, Tony, Patel, Rajiv M, Harms, Paul W, Betz, Bryan L, Schuetze, Scott M, McHugh, Jonathan B, Horvai, Andrew E, Cho, Soo-Jin, Lucas, David R

“…In recent years, a novel small round cell sarcoma harboring EWSR1-NFATC2 translocation with immunomorphologic overlap with Ewing sarcoma (ES), myoepithelial…”
Get full text

Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza by Schulert, Grant S., Zhang, Mingce, Fall, Ndate, Husami, Ammar, Kissell, Diane, Hanosh, Andrew, Zhang, Kejian, Davis, Kristina, Jentzen, Jeffrey M., Napolitano, Lena, Siddiqui, Javed, Smith, Lauren B., Harms, Paul W., Grom, Alexei A., Cron, Randy Q.

“…Background. Severe H1N1 influenza can be lethal in otherwise healthy individuals and can have features of reactive hemophagocytic lymphohistiocytosis (HLH)…”
Get full text

A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases by Liang, Yun, Tsoi, Lam C, Xing, Xianying, Beamer, Maria A, Swindell, William R, Sarkar, Mrinal K, Berthier, Celine C, Stuart, Philip E, Harms, Paul W, Nair, Rajan P, Elder, James T, Voorhees, John J, Kahlenberg, J Michelle, Gudjonsson, Johann E

“…Various autoimmune diseases have sex-linked biases. Gudjonsson and colleagues find that the transcription factor VGLL3 is associated with a female-biased…”
Get full text

DEGRO practical guideline for partial-breast irradiation by Strnad, V., Krug, D., Sedlmayer, F., Piroth, M. D., Budach, W., Baumann, R., Feyer, P., Duma, M. N., Haase, W., Harms, W., Hehr, T., Fietkau, R., Dunst, J., Sauer, R.

“…Purpose This consensus statement from the Breast Cancer Working Group of the German Society for Radiation Oncology (DEGRO) aims to define practical guidelines…”
Get full text

Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma by Wong, Kim, van der Weyden, Louise, Schott, Courtney R., Foote, Alastair, Constantino-Casas, Fernando, Smith, Sionagh, Dobson, Jane M., Murchison, Elizabeth P., Wu, Hong, Yeh, Iwei, Fullen, Douglas R., Joseph, Nancy, Bastian, Boris C., Patel, Rajiv M., Martincorena, Inigo, Robles-Espinoza, Carla Daniela, Iyer, Vivek, Kuijjer, Marieke L., Arends, Mark J., Brenn, Thomas, Harms, Paul W., Wood, Geoffrey A., Adams, David J.

“…Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here we perform a cross-species analysis by sequencing tumor-germline pairs from…”
Get full text

Extensive Survey of STAT6 Expression in a Large Series of Mesenchymal Tumors by Demicco, Elizabeth G., Harms, Paul W., Patel, Rajiv M., Smith, Steven C., Ingram, Davis, Torres, Keila, Carskadon, Shannon L., Camelo-Piragua, Sandra, McHugh, Jonathan B., Siddiqui, Javed, Palanisamy, Nallasivam, Lucas, David R., Lazar, Alexander J., Wang, Wei-Lien

“…Objectives: Expression of strong nuclear STAT6 is thought to be a specific marker for solitary fibrous tumors (SFTs). Little is known about subtle expression…”
Get full text

Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma by Potu, Harish, Peterson, Luke F., Kandarpa, Malathi, Pal, Anupama, Sun, Hanshi, Durham, Alison, Harms, Paul W., Hollenhorst, Peter C., Eskiocak, Ugur, Talpaz, Moshe, Donato, Nicholas J.

“…ETS transcription factors are commonly deregulated in cancer by chromosomal translocation, overexpression or post-translational modification to induce gene…”
Get full text

Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes by Dhanasekaran, Saravana M., Alejandro Balbin, O, Chen, Guoan, Nadal, Ernest, Kalyana-Sundaram, Shanker, Pan, Jincheng, Veeneman, Brendan, Cao, Xuhong, Malik, Rohit, Vats, Pankaj, Wang, Rui, Huang, Stephanie, Zhong, Jinjie, Jing, Xiaojun, Iyer, Matthew, Wu, Yi-Mi, Harms, Paul W., Lin, Jules, Reddy, Rishindra, Brennan, Christine, Palanisamy, Nallasivam, Chang, Andrew C., Truini, Anna, Truini, Mauro, Robinson, Dan R., Beer, David G., Chinnaiyan, Arul M.

“…Lung cancer is emerging as a paradigm for disease molecular subtyping, facilitating targeted therapy based on driving somatic alterations. Here we perform…”
Get full text

Next generation sequencing of Cytokeratin 20-negative Merkel cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivation by Harms, Paul W, Collie, Angela M B, Hovelson, Daniel H, Cani, Andi K, Verhaegen, Monique E, Patel, Rajiv M, Fullen, Douglas R, Omata, Kei, Dlugosz, Andrzej A, Tomlins, Scott A, Billings, Steven D

“…Merkel cell carcinoma is a rare but highly aggressive cutaneous neuroendocrine carcinoma. Cytokeratin 20 (CK20) is expressed in ~95% of Merkel cell carcinomas…”
Get full text

Atypical Spitz Tumors: A Diagnostic Challenge by Harms, Kelly L, Lowe, Lori, Fullen, Douglas R, Harms, Paul W

“…Spitzoid melanocytic lesions encompass a spectrum from benign Spitz nevi to malignant spitzoid melanomas. Spitzoid melanocytic neoplasms have significant…”
Get full text

Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis by Ma, Feiyang, Tsou, Pei-Suen, Gharaee-Kermani, Mehrnaz, Plazyo, Olesya, Xing, Xianying, Kirma, Joseph, Wasikowski, Rachael, Hile, Grace A., Harms, Paul W., Jiang, Yanyun, Xing, Enze, Nakamura, Mio, Ochocki, Danielle, Brodie, William D., Pillai, Shiv, Maverakis, Emanual, Pellegrini, Matteo, Modlin, Robert L., Varga, John, Tsoi, Lam C., Lafyatis, Robert, Kahlenberg, J. Michelle, Billi, Allison C., Khanna, Dinesh, Gudjonsson, Johann E.

“…Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to…”
Get full text

Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia? by Rittié, Laure, Tejasvi, Trilokraj, Harms, Paul W., Xing, Xianying, Nair, Rajan P., Gudjonsson, Johann E., Swindell, William R., Elder, James T.

“…In a transcriptome study of lesional psoriatic skin (PP) versus normal skin, we found a coexpressed gene module (N5) enriched 11.5-fold for lipid biosynthetic…”
Get full text