Search Results - "Harms, Joerg M"

Translational Regulation via L11: Molecular Switches on the Ribosome Turned On and Off by Thiostrepton and Micrococcin by Harms, Joerg M., Wilson, Daniel N., Schluenzen, Frank, Connell, Sean R., Stachelhaus, Torsten, Zaborowska, Zaneta, Spahn, Christian M.T., Fucini, Paola

“…The thiopeptide class of antibiotics targets the GTPase-associated center (GAC) of the ribosome to inhibit translation factor function. Using X-ray…”
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oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning by Wilson, Daniel N, Schluenzen, Frank, Harms, Joerg M, Starosta, Agata L, Connell, Sean R, Fucini, Paola

“…The oxazolidinones represent the first new class of antibiotics to enter into clinical usage within the past 30 years, but their binding site and mechanism of…”
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The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation by Yokoyama, Shigeyuki, Fucini, Paola, Schluenzen, Frank, Takemoto, Chie, Wilson, Daniel N, Kaminishi, Tatsuya, Harms, Joerg M, Hanawa-Suetsugu, Kyoko, Szaflarski, Witold, Kawazoe, Masahito, Shirouzu, Mikako, Nierhaus, Knud H

“…Kasugamycin (Ksg) specifically inhibits translation initiation of canonical but not of leaderless messenger RNAs. Ksg inhibition is thought to occur by direct…”
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A Snapshot of the 30S Ribosomal Subunit Capturing mRNA via the Shine-Dalgarno Interaction by Kaminishi, Tatsuya, Wilson, Daniel N., Takemoto, Chie, Harms, Joerg M., Kawazoe, Masahito, Schluenzen, Frank, Hanawa-Suetsugu, Kyoko, Shirouzu, Mikako, Fucini, Paola, Yokoyama, Shigeyuki

“…In the initiation phase of bacterial translation, the 30S ribosomal subunit captures mRNA in preparation for binding with initiator tRNA. The purine-rich…”
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X-ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit by Wilson, Daniel N, Schluenzen, Frank, Harms, Joerg M, Yoshida, Takuya, Ohkubo, Tadayasu, Albrecht, Renate, Buerger, Joerg, Kobayashi, Yuji, Fucini, Paola

“…This study presents the crystal structure of domain I of the Escherichia coli ribosome recycling factor (RRF) bound to the Deinococcus radiodurans 50S subunit…”
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Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections by Van Bambeke, Françoise, Harms, Joerg M, Van Laethem, Yves, Tulkens, Paul M

“…Ketolides differ from macrolides by removal of the 3-O-cladinose (replaced by a keto group), a 11,12- or 6,11-cyclic moiety and a heteroaryl-alkyl side chain…”
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SnapShot: Antibiotic Inhibition of Protein Synthesis I by Sohmen, Daniel, Harms, Joerg M., Schlünzen, Frank, Wilson, Daniel N.

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Enhanced SnapShot: Antibiotic Inhibition of Protein Synthesis II by Sohmen, Daniel, Harms, Joerg M., Schlünzen, Frank, Wilson, Daniel N.

“…The translational apparatus is one of the major targets for antibiotics in the bacterial cell. Antibiotics predominantly interact with the functional centers…”
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Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin by Harms, Jörg M, Schlünzen, Frank, Fucini, Paola, Bartels, Heike, Yonath, Ada

“…The bacterial ribosome is a primary target of several classes of antibiotics. Investigation of the structure of the ribosomal subunits in complex with…”
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Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin by Schlünzen, Frank, Pyetan, Erez, Fucini, Paola, Yonath, Ada, Harms, Jörg M.

“…Summary Tiamulin, a prominent member of the pleuromutilin class of antibiotics, is a potent inhibitor of protein synthesis in bacteria. Up to now the effect of…”
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Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation by Diaconu, Mihaela, Kothe, Ute, Schlünzen, Frank, Fischer, Niels, Harms, Jörg M., Tonevitsky, Alexander G., Stark, Holger, Rodnina, Marina V., Wahl, Markus C.

“…The L7/12 stalk of the large subunit of bacterial ribosomes encompasses protein L10 and multiple copies of L7/12. We present crystal structures of Thermotoga…”
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Erratum: The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation by Schluenzen, Frank, Takemoto, Chie, Wilson, Daniel N, Kaminishi, Tatsuya, Harms, Joerg M, Hanawa-Suetsugu, Kyoko, Szaflarski, Witold, Kawazoe, Masahito, Shirouzu, Mikako, Nierhaus, Knud H, Yokoyama, Shigeyuki, Fucini, Paola

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The binding mode of the trigger factor on the ribosome: Implications for protein folding and SRP interaction by Fucini, Paola, Schluenzen, Frank, Wilson, Daniel N, Tian, Pingsheng, Harms, Joerg M., McKinnes, Stuart, Hansen, Harley, Albrecht, Renate, Buerger, Joerg, Wilbanks, Sigurd

“…This study presents the X‐ray structure of the N‐terminal binding domain of the D. radiodurans trigger factor (TF) in complex with the D. radiodurans large…”
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Die Anatomie des Ribosoms. Kristallographie mit Synchrotronlicht by Schlünzen, Frank, Harms, Jörg M.

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