Search Results - "Harms, Jörg M"
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Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin
Published in Molecular microbiology (01-12-2004)“…Summary Tiamulin, a prominent member of the pleuromutilin class of antibiotics, is a potent inhibitor of protein synthesis in bacteria. Up to now the effect of…”
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Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation
Published in Cell (01-07-2005)“…The L7/12 stalk of the large subunit of bacterial ribosomes encompasses protein L10 and multiple copies of L7/12. We present crystal structures of Thermotoga…”
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Structural Basis for the Antibiotic Activity of Ketolides and Azalides
Published in Structure (London) (01-03-2003)“…The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of erythromycin, exhibit elevated activity against a number of…”
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Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin
Published in BMC biology (01-04-2004)“…The bacterial ribosome is a primary target of several classes of antibiotics. Investigation of the structure of the ribosomal subunits in complex with…”
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The Binding Mode of the Trigger Factor on the Ribosome: Implications for Protein Folding and SRP Interaction
Published in Structure (London) (01-11-2005)“…This study presents the X-ray structure of the N-terminal binding domain of the D. radiodurans trigger factor (TF) in complex with the D. radiodurans large…”
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Antibiotics acting on the translational machinery
Published in Journal of cell science (15-04-2003)Get full text
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Species-specific antibiotic-ribosome interactions: implications for drug development
Published in Biological chemistry (01-12-2005)“…In the cell, the protein synthetic machinery is a highly complex apparatus that offers many potential sites for functional interference and therefore…”
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The structure of the lateral stalk of the large ribosomal subunit and its implications for factor mediated initiation and translocation
Published in The FASEB journal (01-03-2006)“…The lateral stalk of the large ribosomal subunit has been long known to play an important role in initiation and elongation factor binding to the ribosome as…”
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Die Anatomie des Ribosoms. Kristallographie mit Synchrotronlicht
Published in Physik in unserer Zeit (01-01-2011)“…Ribosomen übersetzen die genetische Information der DNA im Schritt der Proteinbiosynthese in die vielfältigen Proteine, die eine Zelle benötigt. Was dabei…”
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Die Anatomie des Ribosoms. Kristallographie mit Synchrotronlicht
Published in Physik in unserer Zeit (01-01-2011)Get full text
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