Search Results - "Harms, Jörg M"

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  1. 1

    Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin by Schlünzen, Frank, Pyetan, Erez, Fucini, Paola, Yonath, Ada, Harms, Jörg M.

    Published in Molecular microbiology (01-12-2004)
    “…Summary Tiamulin, a prominent member of the pleuromutilin class of antibiotics, is a potent inhibitor of protein synthesis in bacteria. Up to now the effect of…”
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    Journal Article
  2. 2

    Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation by Diaconu, Mihaela, Kothe, Ute, Schlünzen, Frank, Fischer, Niels, Harms, Jörg M., Tonevitsky, Alexander G., Stark, Holger, Rodnina, Marina V., Wahl, Markus C.

    Published in Cell (01-07-2005)
    “…The L7/12 stalk of the large subunit of bacterial ribosomes encompasses protein L10 and multiple copies of L7/12. We present crystal structures of Thermotoga…”
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    Journal Article
  3. 3

    Structural Basis for the Antibiotic Activity of Ketolides and Azalides by Schlünzen, Frank, Harms, Jörg M, Franceschi, Francois, Hansen, Harly A.S, Bartels, Heike, Zarivach, Raz, Yonath, Ada

    Published in Structure (London) (01-03-2003)
    “…The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of erythromycin, exhibit elevated activity against a number of…”
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    Journal Article
  4. 4

    Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin by Harms, Jörg M, Schlünzen, Frank, Fucini, Paola, Bartels, Heike, Yonath, Ada

    Published in BMC biology (01-04-2004)
    “…The bacterial ribosome is a primary target of several classes of antibiotics. Investigation of the structure of the ribosomal subunits in complex with…”
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  5. 5

    The Binding Mode of the Trigger Factor on the Ribosome: Implications for Protein Folding and SRP Interaction by Schlünzen, Frank, Wilson, Daniel N., Tian, Pingsheng, Harms, Jörg M., McInnes, Stuart J., Hansen, Harly A.S., Albrecht, Renate, Buerger, Jörg, Wilbanks, Sigurd M., Fucini, Paola

    Published in Structure (London) (01-11-2005)
    “…This study presents the X-ray structure of the N-terminal binding domain of the D. radiodurans trigger factor (TF) in complex with the D. radiodurans large…”
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  6. 6
  7. 7

    Species-specific antibiotic-ribosome interactions: implications for drug development by Wilson, Daniel N, Harms, Jörg M, Nierhaus, Knud H, Schlünzen, Frank, Fucini, Paola

    Published in Biological chemistry (01-12-2005)
    “…In the cell, the protein synthetic machinery is a highly complex apparatus that offers many potential sites for functional interference and therefore…”
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  8. 8

    The structure of the lateral stalk of the large ribosomal subunit and its implications for factor mediated initiation and translocation by Schlünzen, Frank, Harms, Jörg M.

    Published in The FASEB journal (01-03-2006)
    “…The lateral stalk of the large ribosomal subunit has been long known to play an important role in initiation and elongation factor binding to the ribosome as…”
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  9. 9

    Die Anatomie des Ribosoms. Kristallographie mit Synchrotronlicht by Schlünzen, Frank, Harms, Jörg M.

    Published in Physik in unserer Zeit (01-01-2011)
    “…Ribosomen übersetzen die genetische Information der DNA im Schritt der Proteinbiosynthese in die vielfältigen Proteine, die eine Zelle benötigt. Was dabei…”
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  10. 10