Search Results - "Harms, Ashley"

Periphery and brain, innate and adaptive immunity in Parkinson’s disease by Harms, Ashley S., Ferreira, Sara A., Romero-Ramos, Marina

“…Parkinson’s disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a central role in the death and dysfunction of neurons, both, in central,…”
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microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease by Thome, Aaron D, Harms, Ashley S, Volpicelli-Daley, Laura A, Standaert, David G

“…Increasing evidence points to inflammation as a chief mediator of Parkinson's disease (PD), a progressive neurodegenerative disorder characterized by loss of…”
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CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease by Williams, Gregory P, Schonhoff, Aubrey M, Jurkuvenaite, Asta, Gallups, Nicole J, Standaert, David G, Harms, Ashley S

“…α-Synuclein, a key pathological component of Parkinson's disease, has been implicated in the activation of the innate and adaptive immune system. This immune…”
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The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia by Cao, Shuwen, Standaert, David G, Harms, Ashley S

“…The protein alpha-synuclein (α-SYN), which is found in the Lewy bodies of dopamine-producing (DA) neurons in the substantia nigra (SN), has an important role…”
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Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease by Thome, Aaron D, Standaert, David G, Harms, Ashley S

“…Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by loss of dopamine neurons in the substantia nigra pars compacta (SNpc) and…”
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Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease by Harms, Ashley S., Thome, Aaron D., Yan, Zhaoqi, Schonhoff, Aubrey M., Williams, Gregory P., Li, Xinru, Liu, Yudong, Qin, Hongwei, Benveniste, Etty N., Standaert, David G.

“…Accumulation of alpha-synuclein (α-syn) in the central nervous system (CNS) is a core feature of Parkinson disease (PD) that leads to activation of the innate…”
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Central and peripheral innate and adaptive immunity in Parkinson's disease by Harms, Ashley S, Yang, Ya-Ting, Tansey, Malú Gámez

“…Parkinson's disease (PD) is a multisystem disorder with characteristics of a chronic inflammatory disease. To develop effective immunomodulatory interventions…”
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How can rAAV-[alpha]-synuclein and the fibril [alpha]-synuclein models advance our understanding of Parkinson's disease? by Volpicelli-Daley, Laura A, Kirik, Deniz, Stoyka, Lindsay E, Standaert, David G, Harms, Ashley S

“…Animal models of Parkinson's disease (PD) are important for understanding the mechanisms of the disease and can contribute to developing and validating novel…”
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'Seeding' the idea of early diagnostics in synucleinopathies by Gallups, Nicole J, Harms, Ashley S

“…This scientific commentary refers to ‘Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies’ by Poggiolini et al…”
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Innate and adaptive immune responses in Parkinson's disease by Schonhoff, Aubrey M, Williams, Gregory P, Wallen, Zachary D, Standaert, David G, Harms, Ashley S

“…Parkinson's disease (PD) has classically been defined as a movement disorder, in which motor symptoms are explained by the aggregation of alpha-synuclein…”
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Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration by Qin, Hongwei, Buckley, Jessica A, Li, Xinru, Liu, Yudong, Fox, 3rd, Thomas H, Meares, Gordon P, Yu, Hao, Yan, Zhaoqi, Harms, Ashley S, Li, Yufeng, Standaert, David G, Benveniste, Etty N

“…Parkinson's Disease (PD) is an age-related, chronic neurodegenerative disorder. At present, there are no disease-modifying therapies to prevent PD progression…”
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Editorial: Glial-targeted therapeutics for CNS disease: getting there from here by Tansey, Malú Gámez, Harms, Ashley S

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MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration by Harms, Ashley S, Cao, Shuwen, Rowse, Amber L, Thome, Aaron D, Li, Xinru, Mangieri, Leandra R, Cron, Randy Q, Shacka, John J, Raman, Chander, Standaert, David G

“…Accumulation of α-synuclein (α-syn) in the brain is a core feature of Parkinson disease (PD) and leads to microglial activation, production of inflammatory…”
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Nigrostriatal tau pathology in parkinsonism and Parkinson's disease by Chu, Yaping, Hirst, Warren D, Federoff, Howard J, Harms, Ashley S, Stoessl, A Jon, Kordower, Jeffrey H

“…While Parkinson's disease remains clinically defined by cardinal motor symptoms resulting from nigrostriatal degeneration, it is now appreciated that the…”
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The emerging role of disease-associated microglia in Parkinson’s disease by Samant, Ritika R., Standaert, David G., Harms, Ashley S.

“…Disease-associated microglia (DAM) are a subset of microglia that appear at various stages of central nervous system neurodegenerative diseases. DAM were…”
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Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson's disease by Williams, Gregory P, Schonhoff, Aubrey M, Jurkuvenaite, Asta, Thome, Aaron D, Standaert, David G, Harms, Ashley S

“…Parkinson's disease (PD) is characterized by intracellular alpha-synuclein (α-syn) inclusions, progressive death of dopaminergic neurons in the substantia…”
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α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration by Harms, Ashley S, Delic, Vedad, Thome, Aaron D, Bryant, Nicole, Liu, Zhiyong, Chandra, Sidhanth, Jurkuvenaite, Asta, West, Andrew B

“…Genetic variation in a major histocompatibility complex II (MHCII)-encoding gene (HLA-DR) increases risk for Parkinson disease (PD), and the accumulation of…”
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How can rAAV‐α‐synuclein and the fibril α‐synuclein models advance our understanding of Parkinson's disease? by Volpicelli‐Daley, Laura A., Kirik, Deniz, Stoyka, Lindsay E., Standaert, David G., Harms, Ashley S.

“…Animal models of Parkinson's disease (PD) are important for understanding the mechanisms of the disease and can contribute to developing and validating novel…”
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T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease by Williams, Gregory P., Marmion, David J., Schonhoff, Aubrey M., Jurkuvenaite, Asta, Won, Woong-Jai, Standaert, David G., Kordower, Jeffrey H., Harms, Ashley S.

“…Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by abnormal accumulation of alpha-synuclein (α-syn) in oligodendrocytes…”
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Inflammation in Experimental Models of α‐Synucleinopathies by Harms, Ashley S., Kordower, Jeffrey H., Sette, Alessandro, Lindestam Arlehamn, Cecilia S., Sulzer, David, Mach, Robert H.

“…ABSTRACT Neuroinflammation has long been associated with central nervous system pathology in α‐synucleinopathy disorders including Parkinson's disease and…”
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