Search Results - "Harmon, Robert M"

Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination by Nekrasova, Oxana, Harmon, Robert M., Broussard, Joshua A., Koetsier, Jennifer L., Godsel, Lisa M., Fitz, Gillian N., Gardel, Margaret L., Green, Kathleen J.

“…The epidermis is a multi-layered epithelium that serves as a barrier against water loss and environmental insults. Its morphogenesis occurs through a tightly…”
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Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin by McAleer, Maeve A., MB, MRCP, Pohler, Elizabeth, PhD, Smith, Frances J.D., PhD, Wilson, Neil J., MSc, Cole, Christian, PhD, MacGowan, Stuart, PhD, Koetsier, Jennifer L., BS, Godsel, Lisa M., PhD, Harmon, Robert M., PhD, Gruber, Robert, MD, Crumrine, Debra, BS, Elias, Peter M., MD, McDermott, Michael, FRCPath, Butler, Karina, FRCPI, Broderick, Annemarie, MRCPI, Sarig, Ofer, PhD, Sprecher, Eli, MD, PhD, Green, Kathleen J., PhD, McLean, W.H. Irwin, PhD, DSc, FRS, FRSE, FMedSci, Irvine, Alan D., MD

“…Background Severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome is a recently recognized syndrome caused by mutations in the desmoglein…”
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Structural and functional diversity of desmosomes by Harmon, Robert M, Green, Kathleen J

“…Desmosomes anchor intermediate filaments at sites of cell contact established by the interaction of cadherins extending from opposing cells. The incorporation…”
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The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1 by Dubash, Adi D, Koetsier, Jennifer L, Amargo, Evangeline V, Najor, Nicole A, Harmon, Robert M, Green, Kathleen J

“…Although much is known about signaling factors downstream of Rho GTPases that contribute to epidermal differentiation, little is known about which upstream…”
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Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis by Roth-Carter, Quinn R, Burks, Hope E, Ren, Ziyou, Koetsier, Jennifer L, Tsoi, Lam C, Harms, Paul W, Xing, Xianying, Kirma, Joseph, Harmon, Robert M, Godsel, Lisa M, Perl, Abbey L, Gudjonsson, Johann E, Green, Kathleen J

“…Darier, Hailey-Hailey, and Grover diseases are rare acantholytic skin diseases. While these diseases have different underlying causes, they share defects in…”
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Epidermolytic Ichthyosis Sine Epidermolysis by Eskin-Schwartz, Marina, Drozhdina, Marianna, Sarig, Ofer, Gat, Andrea, Jackman, Tomer, Isakov, Ofer, Shomron, Noam, Samuelov, Liat, Malchin, Natalia, Peled, Alon, Vodo, Dan, Hovnanian, Alain, Ruzicka, Thomas, Koshkin, Sergei, Harmon, Robert M, Koetsier, Jennifer L, Green, Kathleen J, Paller, Amy S, Sprecher, Eli

“…Epidermolytic ichthyosis (EI) is a rare disorder of cornification caused by mutations in KRT1 and KRT10, encoding two suprabasal epidermal keratins. Because of…”
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Endoplasmic reticulum tethering by desmosomes by Harmon, Robert M., Gottardi, Cara J.

“…Desmosomes and keratin are now found to regulate the distribution and dynamics of the endoplasmic reticulum (ER). This suggests that a range of ER functions…”
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Dia1 coordinates differentiation and cell sorting in a stratified epithelium by Harmon, Robert M, Devany, John, Gardel, Margaret L

“…Although implicated in adhesion, only a few studies address how the actin assembly factors guide cell positioning in multicellular tissues. The formin, Dia1,…”
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Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting by Samuelov, Liat, Sarig, Ofer, Harmon, Robert M, Rapaport, Debora, Ishida-Yamamoto, Akemi, Isakov, Ofer, Koetsier, Jennifer L, Gat, Andrea, Goldberg, Ilan, Bergman, Reuven, Spiegel, Ronen, Eytan, Ori, Geller, Shamir, Peleg, Sarit, Shomron, Noam, Goh, Christabelle S M, Wilson, Neil J, Smith, Frances J D, Pohler, Elizabeth, Simpson, Michael A, McLean, W H Irwin, Irvine, Alan D, Horowitz, Mia, McGrath, John A, Green, Kathleen J, Sprecher, Eli

“…Eli Sprecher, Kathleen Green and colleagues show that biallelic mutations in DSG1 cause a syndrome featuring severe dermatitis, multiple allergies and…”
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Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation by Harmon, Robert M, Simpson, Cory L, Johnson, Jodi L, Koetsier, Jennifer L, Dubash, Adi D, Najor, Nicole A, Sarig, Ofer, Sprecher, Eli, Green, Kathleen J

“…Genetic disorders of the Ras/MAPK pathway, termed RASopathies, produce numerous abnormalities, including cutaneous keratodermas. The desmosomal cadherin,…”
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Desmosomes at a glance by Desai, Bhushan V, Harmon, Robert M, Green, Kathleen J

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Different roles of cadherins in the assembly and structural integrity of the desmosome complex by Lowndes, Molly, Rakshit, Sabyasachi, Shafraz, Omer, Borghi, Nicolas, Harmon, Robert M, Green, Kathleen J, Sivasankar, Sanjeevi, Nelson, W James

“…Adhesion between cells is established by the formation of specialized intercellular junctional complexes, such as desmosomes. Desmosomes contain isoforms of…”
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Intermediate Filaments and the Plasma Membrane by Jones, Jonathan C R, Kam, Chen Yuan, Harmon, Robert M, Woychek, Alexandra V, Hopkinson, Susan B, Green, Kathleen J

“…A variety of intermediate filament (IF) types show intricate association with plasma membrane proteins, including receptors and adhesion molecules. The…”
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Characterization of karyopherins in androgen receptor intracellular trafficking in the yeast model by Nguyen, Minh M, Harmon, Robert M, Wang, Zhou

“…Mechanisms regulating androgen receptor (AR) subcellular localization represent an essential component of AR signaling. Karyopherins are a family of…”
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Intracellular Desmoglein-1 Domains Promote Epidermal Differentiation By Forming a MAPK Inhibitory Apparatus by Harmon, Robert M

“…Desmosomes, complex structures found at cell junctions, strengthen tissue by mechanically linking the cytoskeletons of adjacent cells. This function is…”
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Intrabiliary metastasis of colorectal mucinous adenocarcinoma mimicking choledocholithiasis 18 years after the primary tumor by Ghaffar, Sumaya Abdul, Pfau, David, Madhuripan, Nikhil, Harmon, Robert Christopher, Galvao Neto, Antonio, Gleisner, Ana Luiza

“…This case report presents a 62-year-old male who had previously undergone curative colectomy and neoadjuvant chemotherapy in 2005 for colorectal cancer. He…”
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Regulatory roles of the cadherin superfamily by Harmon, Robert M, Desai, Bhushan V, Green, Kathleen J

“…Charged with the task of providing a molecular link between adjacent cells, the cadherin superfamily consists of over 100 members and populates the genomes of…”
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