Search Results - "Harmon, Jeffrey M"

Identification of Small Subunits of Mammalian Serine Palmitoyltransferase That Confer Distinct Acyl-CoA Substrate Specificities by Han, Gongshe, Gupta, Sita D., Gable, Kenneth, Niranjanakumari, Somashekarappa, Moitra, Prasun, Eichler, Florian, Brown, Robert H., Harmon, Jeffrey M., Dunn, Teresa M., Merrill, Alfred H.

“…Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In yeast SPT is composed of a heterodimer of 2…”
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A Disease-causing Mutation in the Active Site of Serine Palmitoyltransferase Causes Catalytic Promiscuity by Gable, Kenneth, Gupta, Sita D., Han, Gongshe, Niranjanakumari, Somashekarappa, Harmon, Jeffrey M., Dunn, Teresa M.

“…The autosomal dominant peripheral sensory neuropathy HSAN1 results from mutations in the LCB1 subunit of serine palmitoyltransferase (SPT). Serum from patients…”
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Expression of the ORMDLS, Modulators of Serine Palmitoyltransferase, Is Regulated by Sphingolipids in Mammalian Cells by Gupta, Sita D., Gable, Kenneth, Alexaki, Aikaterini, Chandris, Panagiotis, Proia, Richard L., Dunn, Teresa M., Harmon, Jeffrey M.

“…The relationship between serine palmitoyltransferase (SPT) activity and ORMDL regulation of sphingolipid biosynthesis was investigated in mammalian HEK293…”
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Topological and Functional Characterization of the ssSPTs, Small Activating Subunits of Serine Palmitoyltransferase by Harmon, Jeffrey M., Bacikova, Dagmar, Gable, Kenneth, Gupta, Sita D., Han, Gongshe, Sengupta, Nivedita, Somashekarappa, Niranjanakumari, Dunn, Teresa M.

“…The topological and functional organization of the two isoforms of the small subunits of human serine palmitoyltransferase (hssSPTs) that activate the…”
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Autophagy regulates sphingolipid levels in the liver[S] by Alexaki, Aikaterini, Gupta, Sita D., Majumder, Saurav, Kono, Mari, Tuymetova, Galina, Harmon, Jeffrey M., Dunn, Teresa M., Proia, Richard L.

“…Sphingolipid levels are tightly regulated to maintain cellular homeostasis. During pathologic conditions such as in aging, inflammation, and metabolic and…”
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Overexpression of the Wild-Type SPT1 Subunit Lowers Desoxysphingolipid Levels and Rescues the Phenotype of HSAN1 by Eichler, Florian S, Hornemann, Thorsten, McCampbell, Alex, Kuljis, Dika, Penno, Anke, Vardeh, Daniel, Tamrazian, Eric, Garofalo, Kevin, Lee, Ho-Joon, Kini, Lohit, Selig, Martin, Frosch, Matthew, Gable, Ken, von Eckardstein, Arnold, Woolf, Clifford J, Guan, Guiman, Harmon, Jeffrey M, Dunn, Teresa M, Brown, Robert H., Jr

“…Mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT) cause an adult-onset, hereditary sensory, and autonomic neuropathy type I (HSAN1). We…”
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Expression of a Novel Marine Viral Single-chain Serine Palmitoyltransferase and Construction of Yeast and Mammalian Single-chain Chimera by Han, Gongshe, Gable, Kenneth, Yan, Lianying, Allen, Michael J., Wilson, William H., Moitra, Prasun, Harmon, Jeffrey M., Dunn, Teresa M.

“…The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi…”
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Tsc10p and FVT1: topologically distinct short-chain reductases required for long-chain base synthesis in yeast and mammals by Gupta, Sita D., Gable, Kenneth, Han, Gongshe, Borovitskaya, Anna, Selby, Luke, Dunn, Teresa M., Harmon, Jeffrey M.

“…In yeast, Tsc10p catalyzes reduction of 3-ketosphinganine to dihydrosphingosine. In mammals, it has been proposed that this reaction is catalyzed by FVT1,…”
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The Topology of the Lcb1p Subunit of Yeast Serine Palmitoyltransferase by Han, Gongshe, Gable, Ken, Yan, Lianying, Natarajan, Mukil, Krishnamurthy, Jayasree, Gupta, Sita D., Borovitskaya, Anna, Harmon, Jeffrey M., Dunn, Teresa M.

“…The structural organization and topology of the Lcb1p subunit of yeast and mammalian serine palmitoyltransferases (SPT) were investigated. In the yeast…”
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The ORMs interact with transmembrane domain 1 of Lcb1 and regulate serine palmitoyltransferase oligomerization, activity and localization by Han, Gongshe, Gupta, Sita D., Gable, Kenneth, Bacikova, Dagmar, Sengupta, Nivedita, Somashekarappa, Niranjanakumari, Proia, Richard L., Harmon, Jeffrey M., Dunn, Teresa M.

“…Serine palmitoyltransferase (SPT), an endoplasmic reticulum-localized membrane enzymecomposed of acatalytic LCB1/LCB2 heterodimer and a small activating…”
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Sphingolipids in the Root Play an Important Role in Regulating the Leaf Ionome in Arabidopsis thaliana by Chao, Dai-Yin, Gable, Kenneth, Chen, Ming, Baxter, Ivan, Dietrich, Charles R, Cahoon, Edgar B, Guerinot, Mary Lou, Lahner, Brett, Lü, Shiyou, Markham, Jonathan E, Morrissey, Joe, Han, Gongshe, Gupta, Sita D, Harmon, Jeffrey M, Jaworski, Jan G, Dunn, Teresa M, Salt, David E

“…Sphingolipid synthesis is initiated by condensation of Ser with palmitoyl-CoA producing 3-ketodihydrosphinganine (3-KDS), which is reduced by a 3-KDS reductase…”
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The Pyridoxal 5′-Phosphate (PLP)-Dependent Enzyme Serine Palmitoyltransferase (SPT): Effects of the Small Subunits and Insights from Bacterial Mimics of Human hLCB2a HSAN1 Mutations by Campopiano, Dominic, Harmon, Jeffrey M., Kazlauskaite, Agne, Frankova, Lenka, Gupta, Sita D., Beattie, Ashley E., Dunn, Teresa M.

“…The pyridoxal 5′-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) catalyses the first step of de novo sphingolipid biosynthesis. The core…”
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Glucocorticoid-Induced Apoptosis and Regulation of NF-κB Activity in Human Leukemic T Cells by Ramdas, Jyoti, Harmon, Jeffrey M.

“…Abstract Glucocorticoid-induced apoptosis was investigated in glucocorticoid-sensitive 6TG1.1 and resistant ICR27TK.3 human leukemic T cells. Following…”
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Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy by McCampbell, Alexander, Truong, David, Broom, Daniel C., Allchorne, Andrew, Gable, Ken, Cutler, Roy G., Mattson, Mark P., Woolf, Clifford J., Frosch, Matthew P., Harmon, Jeffrey M., Dunn, Teresa M., Brown, Robert H.

“…Mutations in enzymes involved in sphingolipid metabolism and trafficking cause a variety of neurological disorders, but details of the molecular…”
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Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells by RAMDAS, J, WET LIU, HARMON, J. M

“…In contrast to the negative autoregulation of glucocorticoid receptor (GR) expression seen in most cells and tissues, GR expression is positively autoregulated…”
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Identification of Human Glucocorticoid Receptor Complementary DNA Clones by Epitope Selection by Weinberger, Cary, Hollenberg, Stanley M., Ong, Estelita S., Harmon, Jeffrey M., Brower, Steven T., Cidlowski, John, Thompson, E. Brad, Rosenfeld, Michael G., Evans, Ronald M.

“…Steroid hormones regulate cellular differentiation and physiologic functions predominantly through gene transcription. Regulation is achieved by the…”
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Role of serine phosphorylation of Stat5a in prolactin-stimulated β-casein gene expression by Yamashita, Hiroko, Nevalainen, Marja T, Xu, Jun, LeBaron, Matthew J, Wagner, Kay-Uwe, Erwin, Rebecca A, Harmon, Jeffrey M, Hennighausen, Lothar, Kirken, Robert A, Rui, Hallgeir

“…Milk production remains suppressed in mammals during late pregnancy despite high levels of lactogenic polypeptide hormones. At parturition, associated with a…”
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Glucocorticoid receptor gene mutations in leukemic cells acquired in vitro and in vivo by Hillmann, A G, Ramdas, J, Multanen, K, Norman, M R, Harmon, J M

“…Glucocorticoid resistance was investigated in human leukemic CCRF-CEM cells. A mutation (L753F), which renders the human glucocorticoid receptor (hGR) gene…”
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Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90 by Scherrer, Lawrence C, Picard, Didier, Massa, Enrique, Harmon, Jeffrey M, Simons, S. Stoney, Yamamoto, Keith R, Pratt, William B

“…Previously, it has been shown that the hormone binding domain of the glucocorticoid receptor acts as a transferable regulatory cassette that can confer…”
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Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells by POWERS, J. H, HILLMANN, A. G, TANG, D. C, HARMON, J. M

“…The molecular basis for the receptorless (r-) and activation-labile (act1) phenotypes of glucocorticoid-resistant mutants isolated from…”
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