Search Results - "Harmin, David A."

AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection by Vierbuchen, Thomas, Ling, Emi, Cowley, Christopher J., Couch, Cameron H., Wang, Xiaofeng, Harmin, David A., Roberts, Charles W.M., Greenberg, Michael E.

“…Enhancer elements are genomic regulatory sequences that direct the selective expression of genes so that genetically identical cells can differentiate and…”
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Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs by Spiegel, Ivo, Mardinly, Alan R., Gabel, Harrison W., Bazinet, Jeremy E., Couch, Cameron H., Tzeng, Christopher P., Harmin, David A., Greenberg, Michael E.

“…The nervous system adapts to experience by inducing a transcriptional program that controls important aspects of synaptic plasticity. Although the molecular…”
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Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function by Cohen, Sonia, Gabel, Harrison W., Hemberg, Martin, Hutchinson, Ashley N., Sadacca, L. Amanda, Ebert, Daniel H., Harmin, David A., Greenberg, Rachel S., Verdine, Vanessa K., Zhou, Zhaolan, Wetsel, William C., West, Anne E., Greenberg, Michael E.

“…Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by…”
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Genome-wide identification and characterization of functional neuronal activity–dependent enhancers by Malik, Athar N, Vierbuchen, Thomas, Hemberg, Martin, Rubin, Alex A, Ling, Emi, Couch, Cameron H, Stroud, Hume, Spiegel, Ivo, Farh, Kyle Kai-How, Harmin, David A, Greenberg, Michael E

“…In this study, the authors describe the subset of activity-regulated enhancers that modulate transcription in cultured neurons and that participate in the…”
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Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network by Yap, Ee-Lynn, Pettit, Noah L., Davis, Christopher P., Nagy, M. Aurel, Harmin, David A., Golden, Emily, Dagliyan, Onur, Lin, Cindy, Rudolph, Stephanie, Sharma, Nikhil, Griffith, Eric C., Harvey, Christopher D., Greenberg, Michael E.

“…Behavioural experiences activate the FOS transcription factor in sparse populations of neurons that are critical for encoding and recalling specific events 1 –…”
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Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes by Wang, Yueqi, Chiola, Simone, Yang, Guang, Russell, Chad, Armstrong, Celeste J., Wu, Yuanyuan, Spampanato, Jay, Tarboton, Paisley, Ullah, H. M. Arif, Edgar, Nicolas U., Chang, Amelia N., Harmin, David A., Bocchi, Vittoria Dickinson, Vezzoli, Elena, Besusso, Dario, Cui, Jun, Cattaneo, Elena, Kubanek, Jan, Shcheglovitov, Aleksandr

“…Human telencephalon is an evolutionarily advanced brain structure associated with many uniquely human behaviors and disorders. However, cell lineages and…”
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MEF2D Drives Photoreceptor Development through a Genome-wide Competition for Tissue-Specific Enhancers by Andzelm, Milena M., Cherry, Timothy J., Harmin, David A., Boeke, Annabel C., Lee, Charlotte, Hemberg, Martin, Pawlyk, Basil, Malik, Athar N., Flavell, Steven W., Sandberg, Michael A., Raviola, Elio, Greenberg, Michael E.

“…Organismal development requires the precise coordination of genetic programs to regulate cell fate and function. MEF2 transcription factors (TFs) play…”
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Evolution of Osteocrin as an activity-regulated factor in the primate brain by Ataman, Bulent, Boulting, Gabriella L., Harmin, David A., Yang, Marty G., Baker-Salisbury, Mollie, Yap, Ee-Lynn, Malik, Athar N., Mei, Kevin, Rubin, Alex A., Spiegel, Ivo, Durresi, Ershela, Sharma, Nikhil, Hu, Linda S., Pletikos, Mihovil, Griffith, Eric C., Partlow, Jennifer N., Stevens, Christine R., Adli, Mazhar, Chahrour, Maria, Sestan, Nenad, Walsh, Christopher A., Berezovskii, Vladimir K., Livingstone, Margaret S., Greenberg, Michael E.

“…Sensory stimuli drive the maturation and function of the mammalian nervous system in part through the activation of gene expression networks that regulate…”
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Genome-Wide Analysis of MEF2 Transcriptional Program Reveals Synaptic Target Genes and Neuronal Activity-Dependent Polyadenylation Site Selection by Flavell, Steven W., Kim, Tae-Kyung, Gray, Jesse M., Harmin, David A., Hemberg, Martin, Hong, Elizabeth J., Markenscoff-Papadimitriou, Eirene, Bear, Daniel M., Greenberg, Michael E.

“…Although many transcription factors are known to control important aspects of neural development, the genome-wide programs that are directly regulated by these…”
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SnapShot-Seq: a method for extracting genome-wide, in vivo mRNA dynamics from a single total RNA sample by Gray, Jesse M, Harmin, David A, Boswell, Sarah A, Cloonan, Nicole, Mullen, Thomas E, Ling, Joseph J, Miller, Nimrod, Kuersten, Scott, Ma, Yong-Chao, McCarroll, Steven A, Grimmond, Sean M, Springer, Michael

“…mRNA synthesis, processing, and destruction involve a complex series of molecular steps that are incompletely understood. Because the RNA intermediates in each…”
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Disruption of DNA-methylation-dependent long gene repression in Rett syndrome by Gabel, Harrison W., Kinde, Benyam, Stroud, Hume, Gilbert, Caitlin S., Harmin, David A., Kastan, Nathaniel R., Hemberg, Martin, Ebert, Daniel H., Greenberg, Michael E.

“…Rett syndrome is caused by mutation of the MECP2 gene that codes for a protein that binds methylated DNA; this study reveals that MeCP2 affects the expression…”
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Widespread transcription at neuronal activity-regulated enhancers by Kuersten, Scott, Kuhl, Dietmar, Gray, Jesse M, Harmin, David A, Greenberg, Michael E, Barbara-Haley, Kellie, Kreiman, Gabriel, Bito, Haruhiko, Wu, Jing, Costa, Allen M, Bear, Daniel M, Hemberg, Martin, Laptewicz, Mike, Markenscoff-Papadimitriou, Eirene, Worley, Paul F, Kim, Tae-Kyung

“…We used genome-wide sequencing methods to study stimulus-dependent enhancer function in mouse cortical neurons. We identified ∼12,000 neuronal…”
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Mapping the cis-regulatory architecture of the human retina reveals noncoding genetic variation in disease by Cherry, Timothy J., Yang, Marty G., Harmin, David A., Tao, Peter, Timms, Andrew E., Bauwens, Miriam, Allikmets, Rando, Jones, Evan M., Chen, Rui, De Baere, Elfride, Greenberg, Michael E.

“…The interplay of transcription factors and cis-regulatory elements (CREs) orchestrates the dynamic and diverse genetic programs that assemble the human central…”
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A NPAS4–NuA4 complex couples synaptic activity to DNA repair by Pollina, Elizabeth A., Gilliam, Daniel T., Landau, Andrew T., Lin, Cindy, Pajarillo, Naomi, Davis, Christopher P., Harmin, David A., Yap, Ee-Lynn, Vogel, Ian R., Griffith, Eric C., Nagy, M. Aurel, Ling, Emi, Duffy, Erin E., Sabatini, Bernardo L., Weitz, Charles J., Greenberg, Michael E.

“…Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the stability of the genome across the long lifespan of postmitotic…”
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Activity-dependent regulome of human GABAergic neurons reveals new patterns of gene regulation and neurological disease heritability by Boulting, Gabriella L., Durresi, Ershela, Ataman, Bulent, Sherman, Maxwell A., Mei, Kevin, Harmin, David A., Carter, Ava C., Hochbaum, Daniel R., Granger, Adam J., Engreitz, Jesse M., Hrvatin, Sinisa, Blanchard, Michael R., Yang, Marty G., Griffith, Eric C., Greenberg, Michael E.

“…Neuronal activity-dependent gene expression is essential for brain development. Although transcriptional and epigenetic effects of neuronal activity have been…”
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Using Whole-Exome Sequencing to Identify Inherited Causes of Autism by Yu, Timothy W., Chahrour, Maria H., Coulter, Michael E., Jiralerspong, Sarn, Okamura-Ikeda, Kazuko, Ataman, Bulent, Schmitz-Abe, Klaus, Harmin, David A., Adli, Mazhar, Malik, Athar N., D’Gama, Alissa M., Lim, Elaine T., Sanders, Stephan J., Mochida, Ganesh H., Partlow, Jennifer N., Sunu, Christine M., Felie, Jillian M., Rodriguez, Jacqueline, Nasir, Ramzi H., Ware, Janice, Joseph, Robert M., Hill, R. Sean, Kwan, Benjamin Y., Al-Saffar, Muna, Mukaddes, Nahit M., Hashmi, Asif, Balkhy, Soher, Gascon, Generoso G., Hisama, Fuki M., LeClair, Elaine, Poduri, Annapurna, Oner, Ozgur, Al-Saad, Samira, Al-Awadi, Sadika A., Bastaki, Laila, Ben-Omran, Tawfeg, Teebi, Ahmad S., Al-Gazali, Lihadh, Eapen, Valsamma, Stevens, Christine R., Rappaport, Leonard, Gabriel, Stacey B., Markianos, Kyriacos, State, Matthew W., Greenberg, Michael E., Taniguchi, Hisaaki, Braverman, Nancy E., Morrow, Eric M., Walsh, Christopher A.

“…Despite significant heritability of autism spectrum disorders (ASDs), their extreme genetic heterogeneity has proven challenging for gene discovery. Studies of…”
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Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement by Cheadle, Lucas, Tzeng, Christopher P., Kalish, Brian T., Harmin, David A., Rivera, Samuel, Ling, Emi, Nagy, M. Aurel, Hrvatin, Sinisa, Hu, Linda, Stroud, Hume, Burkly, Linda C., Chen, Chinfei, Greenberg, Michael E.

“…Sensory experience influences the establishment of neural connectivity through molecular mechanisms that remain unclear. Here, we employ single-nucleus RNA…”
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Genomic mapping and cellular expression of human CPG2 transcripts in the SYNE1 gene by Loebrich, Sven, Rathje, Mette, Hager, Emily, Ataman, Bulent, Harmin, David A., Greenberg, Michael E., Nedivi, Elly

“…Bipolar disorder (BD) is a prevalent and severe mood disorder characterized by recurrent episodes of mania and depression. Both genetic and environmental…”
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START: an automated tool for serial analysis of chromatin occupancy data by Marinescu, Voichita D., Kohane, Isaac S., Kim, Tae-Kyung, Harmin, David A., Greenberg, Michael E., Riva, Alberto

“…The serial analysis of chromatin occupancy technique (SACO) promises to become a widely used method for the unbiased genome-wide experimental identification of…”
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AP-1 transcription factors and the SWI/SNF complex mediate signal-dependent enhancer selection by Vierbuchen, Thomas, Ling, Emi, Cowley, Christopher J., Couch, Cameron H., Wang, Xiaofeng, Harmin, David A., Roberts, Charles W.M., Greenberg, Michael E.

“…Enhancer elements are regulatory sequences within genomes that direct the selective expression of genes so that genetically identical cells can differentiate…”
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