Search Results - "Harmatz, Jerold S"

Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration by Greenblatt, David J., Harmatz, Jerold S., Singh, Nikhilesh N., Steinberg, Frank, Roth, Thomas, Moline, Margaret L., Harris, Stephen C., Kapil, Ram P.

“…The effect of dose and gender on the pharmacokinetics (PK) and pharmacodynamics (PD) of zolpidem after administration of a buffered zolpidem sublingual tablet…”
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Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers by Volak, Laurie P., Hanley, Michael J., Masse, Gina, Hazarika, Suwagmani, Harmatz, Jerold S., Badmaev, Vladimir, Majeed, Muhammed, Greenblatt, David J., Court, Michael H.

“…Aims Turmeric extract derived curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) are currently being evaluated for the treatment of cancer and…”
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Mechanism of cytochrome P450-3A inhibition by ketoconazole by Greenblatt, David J., Zhao, Yanli, Venkatakrishnan, Karthik, Duan, Su X., Harmatz, Jerold S., Parent, Sarah J., Court, Michael H., von Moltke, Lisa L.

“…Objectives  Ketoconazole is extensively used as an index inhibitor of cytochrome P450‐3A (CYP3A) activity in vitro and in vivo, but the mechanism of…”
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Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen by Zhao, Yanli, Harmatz, Jerold S., Epstein, Carol R., Nakagawa, Yukako, Kurosaki, Chie, Nakamura, Tetsuro, Kadota, Takumi, Giesing, Dennis, Court, Michael H., Greenblatt, David J.

“…Aims The antiviral agent favipiravir is likely to be co‐prescribed with acetaminophen (paracetamol). The present study evaluated the possiblility of a…”
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Comparison of Pharmacokinetic Profiles of Zolpidem Buffered Sublingual Tablet and Zolpidem Oral Immediate-Release Tablet: Results from a Single-Center, Single-Dose, Randomized, Open-Label Crossover Study in Healthy Adults by Greenblatt, David J., MD, Harmatz, Jerold S., AB, Roth, Thomas, PhD, Singh, Nikhilesh N., PhD, Moline, Margaret L., PhD, Harris, Stephen C., MD, Kapil, Ram P., PhD

“…Abstract Background A zolpidem sublingual tablet (ZST) formulation was recently approved by the US Food and Drug Administration to treat middle-of-the-night…”
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Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion by He, Xi, Hesse, Leah M., Hazarika, Suwagmani, Masse, Gina, Harmatz, Jerold S., Greenblatt, David J., Court, Michael H.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • UDP‐glucuronosyltransferase (UGT) 2B15 is a major drug glucuronidation enzyme expressed in human liver. • Oxazepam…”
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Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily by Reddy, Patrick, Ellington, David, Zhu, Yiliang, Zdrojewski, Immo, Parent, Sarah J., Harmatz, Jerold S., Derendorf, Hartmut, Greenblatt, David J., Browne, Jr, Kevin

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • In previous studies of healthy volunteers, administration of atorvastatin with very large quantities of grapefruit…”
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Zolpidem and Gender: Are Women Really At Risk? by Greenblatt, David J, Harmatz, Jerold S, Roth, Thomas

“…In 2013 the Food and Drug Administration (FDA) claimed the existence of new data showing women to be at risk for excessive daytime sedation and impaired…”
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Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450‐3A in drug–drug interaction studies by Greenblatt, David J., Harmatz, Jerold S.

“…Aims The regulatory prohibition of ketoconazole as a CYP3A index inhibitor in drug–drug interaction (DDI) studies has compelled consideration of alternative…”
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Inhibition of human cytochromes P450 by components of Ginkgo biloba by von Moltke, Lisa L., Weemhoff, James L., Bedir, Erdal, Khan, Ikhlas A., Harmatz, Jerold S., Goldman, Peter, Greenblatt, David J.

“…The extraction, isolation and characterization of 29 natural products contained in Ginkgo biloba have been described, which we have now tested for their…”
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Effect of lipophilicity on drug distribution and elimination: Influence of obesity by Bruno, Christopher D., Harmatz, Jerold S., Duan, Su X., Zhang, Qingchen, Chow, Christina R., Greenblatt, David J.

“…Aims For a given passively‐distributed lipophilic drug, the extent of in vivo distribution (pharmacokinetic volume of distribution, Vd) in obese individuals…”
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Drug Disposition in Subjects With Obesity: The Research Work of Darrell R. Abernethy by Greenblatt, David J., Bruno, Christopher D., Harmatz, Jerold S., Zhang, Qingchen, Chow, Christina R.

“…In 1979, the late Dr. Darrell R. Abernethy and colleagues began a series of clinical studies aimed at understanding the pertinent determinants of drug…”
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Comparison between Cytochrome P450 (CYP) Content and Relative Activity Approaches to Scaling from cDNA-Expressed CYPs to Human Liver Microsomes: Ratios of Accessory Proteins as Sources of Discrepancies between the Approaches by VENKATAKRISHNAN, Karthik, VON MOLTKE, Lisa L, COURT, Michael H, HARMATZ, Jerold S, CRESPI, Charles L, GREENBLATT, David J

“…Relative activity factors (RAFs) and immunoquantified levels of cytochrome P450 (CYP) isoforms both have been proposed as scaling factors for the prediction of…”
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Clinical Consequences of Altered Drug Disposition in Obesity: Call for Change by Bruno, Christopher D., Greenblatt, David J., Harmatz, Jerold S., Chow, Christina R.

“…Abstract Obesity is a serious condition with many known comorbid conditions and other health risks. Despite the rising global rates of obesity, drug…”
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Update on Psychotropic Drug Prescribing in the United States: 2014-2015 by Greenblatt, David J, Harmatz, Jerold S, Shader, Richard I

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Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers by Court, Michael H, Zhu, Zhaohui, Masse, Gina, Duan, Su X, James, Laura P, Harmatz, Jerold S, Greenblatt, David J

“…Over 30 years ago, black Africans from Kenya and Ghana were shown to metabolize acetaminophen faster by glucuronidation and slower by oxidation compared with…”
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Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men by Olubodun, Joel O., Ochs, Hermann R., Von Moltke, Lisa L., Roubenoff, Ronenn, Hesse, Leah M., Harmatz, Jerold S., Shader, Richard I., Greenblatt, David J.

“…Aims  The influence of ageing on the pharmacokinetics of zolpidem, an extensively prescribed hypnotic medication, was evaluated in healthy human volunteers…”
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Diazepam in the Elderly: Looking Back, Ahead, and at the Evidence by Greenblatt, David J., Harmatz, Jerold S., Shader, Richard I.

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Vortioxetine Disposition in Obesity: Potential Implications for Patient Safety by Greenblatt, David J, Harmatz, Jerold S, Chow, Christina R

“…Obesity and depression are common comorbid conditions. The objective of the study was to evaluate the effect of obesity on the pharmacokinetics of the…”
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Fluvoxamine impairs single‐dose caffeine clearance without altering caffeine pharmacodynamics by Culm‐Merdek, Kerry E., Von Moltke, Lisa L., Harmatz, Jerold S., Greenblatt, David J.

“…Background Coadministration of fluvoxamine impairs the clearance of caffeine and prolongs its elimination half‐life, which is attributable to inhibition of…”
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