Search Results - "Harman, Rebecca"

Natural Products That Contain Higher Homologated Amino Acids by Owens, Skyler L., Ahmed, Shopno R., Lang Harman, Rebecca M., Stewart, Laura E., Mori, Shogo

“…This review focuses on discussing natural products (NPs) that contain higher homologated amino acids (homoAAs) in the structure as well as the proposed and…”
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Characterization of HphA: The First Enzyme in the Homologation Pathway of l-Phenylalanine and l-Tyrosine by Stewart, Laura E, Owens, Skyler L, Ahmed, Shopno R, Lang Harman, Rebecca M, Mori, Shogo

“…Homologation of amino acids is the insertion or deletion of a methylene group to their side chain, which is a relatively uncommon chemical transformation…”
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A xenotransplantation mouse model to study physiology of the mammary gland from large mammals by Miller, James L, Reddy, Alexandra, Harman, Rebecca M, Van de Walle, Gerlinde R

“…Although highly conserved in structure and function, many (patho)physiological processes of the mammary gland vary drastically between mammals, with mechanisms…”
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Bovine milk-derived cells express transcriptome markers of pluripotency and secrete bioactive factors with regenerative and antimicrobial activity by Danev, Nikola, Harman, Rebecca M., Oliveira, Leane, Huntimer, Lucas, Van de Walle, Gerlinde R.

“…The bovine mammary stem/progenitor cell secretome stimulates regeneration in vitro and contains proteins associated with antimicrobial defense. This has led to…”
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The mesenchymal stromal cell secretome impairs methicillin‐resistant Staphylococcus aureus biofilms via cysteine protease activity in the equine model by Marx, Charlotte, Gardner, Sophia, Harman, Rebecca M., Van de Walle, Gerlinde R.

“…Mesenchymal stromal cells (MSCs) from various species, such as humans, mice, and horses, were recently found to effectively inhibit the growth of various…”
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Mesenchymal stromal cell‐secreted CCL2 promotes antibacterial defense mechanisms through increased antimicrobial peptide expression in keratinocytes by Marx, Charlotte, Gardner, Sophia, Harman, Rebecca M., Wagner, Bettina, Van de Walle, Gerlinde R.

“…Mesenchymal stromal cells (MSCs) from both humans and horses, which represent a clinically relevant translation animal model for human cutaneous wound healing,…”
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Paternally expressed genes predominate in the placenta by Wang, Xu, Miller, Donald C., Harman, Rebecca, Antczak, Douglas F., Clark, Andrew G.

“…The discovery of genomic imprinting through studies of manipulated mouse embryos indicated that the paternal genome has a major influence on placental…”
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Fractionated photoimmunotherapy stimulates an anti-tumour immune response: an integrated mathematical and in vitro study by Zahid, Mohammad U., Waguespack, Matthew, Harman, Rebecca C., Kercher, Eric M., Nath, Shubhankar, Hasan, Tayyaba, Rizvi, Imran, Spring, Bryan Q., Enderling, Heiko

“…Background Advanced epithelial ovarian cancer (EOC) has high recurrence rates due to disseminated initial disease presentation. Cytotoxic phototherapies, such…”
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Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds by Harman, Rebecca M, Yang, Steven, He, Megan K, Van de Walle, Gerlinde R

“…The prevalence of chronic skin wounds in humans is high, and treatment is often complicated by the presence of pathogenic bacteria. Therefore, safe and…”
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The mesenchymal stromal cell secretome promotes tissue regeneration and increases macrophage infiltration in acute and methicillin-resistant Staphylococcus aureus-infected skin wounds in vivo by Rajesh, Aarthi, Ju, Esther Da Eun, Oxford, Kelly A., Harman, Rebecca M., Van de Walle, Gerlinde R.

“…The prevalence of chronic wounds continues to be a burden in human medicine. Methicillin-resistant Staphylococcus aureus (MRSA) is commonly isolated from…”
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Birth, evolution, and transmission of satellite-free mammalian centromeric domains by Nergadze, Solomon G, Piras, Francesca M, Gamba, Riccardo, Corbo, Marco, Cerutti, Federico, McCarter, Joseph G W, Cappelletti, Eleonora, Gozzo, Francesco, Harman, Rebecca M, Antczak, Douglas F, Miller, Donald, Scharfe, Maren, Pavesi, Giulio, Raimondi, Elena, Sullivan, Kevin F, Giulotto, Elena

“…Mammalian centromeres are associated with highly repetitive DNA (satellite DNA), which has so far hindered molecular analysis of this chromatin domain…”
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Effect of pregnancy on isolation efficiency and in vitro proliferation of equine peripheral-blood derived mesenchymal stromal cells by Mattei, Debora N., Harman, Rebecca M., Van de Walle, Gerlinde R., Smith, Roger, Grivel, Jean Charles, Abdelalim, Essam M., Vinardell, Tatiana

“…Mesenchymal stromal cells (MSCs) have regenerative and immunomodulatory potential and may be used to treat injured tissues. Pregnancy has been associated with…”
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Establishment and characterization of equine mammary organoids using a method translatable to other non-traditional model species by Bartlett, Arianna P, Harman, Rebecca M, Weiss, Jennifer R, Van de Walle, Gerlinde R

“…Mammary organoid (MaO) models are only available for a few traditional model organisms, limiting our ability to investigate mammary gland development and…”
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Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer by Miller, James L., Bartlett, Arianna P., Harman, Rebecca M., Majhi, Prabin Dhangada, Jerry, D. Joseph, Van de Walle, Gerlinde R.

“…Mammary cancer, or breast cancer in women, is a polygenic disease with a complex etiopathogenesis. While much remains elusive regarding its origin, it is well…”
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Single-cell RNA sequencing of equine mesenchymal stromal cells from primary donor-matched tissue sources reveals functional heterogeneity in immune modulation and cell motility by Harman, Rebecca M, Patel, Roosheel S, Fan, Jennifer C, Park, Jee E, Rosenberg, Brad R, Van de Walle, Gerlinde R

“…The efficacy of mesenchymal stromal cell (MSC) therapy is thought to depend on the intrinsic heterogeneity of MSC cultures isolated from different tissue…”
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The mammosphere-derived epithelial cell secretome modulates neutrophil functions in the bovine model by Harman, Rebecca M, Sipka, Anja, Oxford, Kelly A, Oliveira, Leane, Huntimer, Lucas, Nydam, Daryl V, Van de Walle, Gerlinde R

“…Innovative therapies against bacterial infections are needed. One approach is to focus on host-directed immunotherapy (HDT), with treatments that exploit…”
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Secreted sphingomyelins modulate low mammary cancer incidence observed in certain mammals by Ledet, Melissa M., Harman, Rebecca M., Fan, Jennifer C., Schmitt-Matzen, Emily, Diaz-Rubio, Maria Elena, Zhang, Sheng, Van de Walle, Gerlinde R.

“…Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel…”
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Translational Animal Models Provide Insight Into Mesenchymal Stromal Cell (MSC) Secretome Therapy by Harman, Rebecca M, Marx, Charlotte, Van de Walle, Gerlinde R

“…The therapeutic potential of the mesenchymal stromal cell (MSC) secretome, consisting of all molecules secreted by MSCs, is intensively studied. MSCs can be…”
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Immortalized mammosphere-derived epithelial cells retain a bioactive secretome with antimicrobial, regenerative, and immunomodulatory properties by Danev, Nikola, Poggi, Julia M, Dewever, Emilie A, Bartlett, Arianna P, Oliveira, Leane, Huntimer, Lucas, Harman, Rebecca M, Van de Walle, Gerlinde R

“…Abstract Background The secretome of primary bovine mammosphere-derived epithelial cells (MDECs) has been shown to exert antimicrobial, regenerative, and…”
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A Mixed Quantum Chemistry/Machine Learning Approach for the Fast and Accurate Prediction of Biochemical Redox Potentials and Its Large-Scale Application to 315 000 Redox Reactions by Jinich, Adrian, Sanchez-Lengeling, Benjamin, Ren, Haniu, Harman, Rebecca, Aspuru-Guzik, Alán

“…A quantitative understanding of the thermodynamics of biochemical reactions is essential for accurately modeling metabolism. The group contribution method…”
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