Search Results - "Harlow, Ed"

A kinase shRNA screen links LATS2 and the pRB tumor suppressor by Tschöp, Katrin, Conery, Andrew R, Litovchick, Larisa, Decaprio, James A, Settleman, Jeffrey, Harlow, Ed, Dyson, Nicholas

“…pRB-mediated inhibition of cell proliferation is a complex process that depends on the action of many proteins. However, little is known about the specific…”
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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E by Fingar, Diane C, Salama, Sofie, Tsou, Christina, Harlow, Ed, Blenis, John

“…The coordinated action of cell cycle progression and cell growth (an increase in cell size and cell mass) is critical for sustained cellular proliferation, yet…”
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Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen by Bommi-Reddy, Archana, Almeciga, Ingrid, Sawyer, Jacqueline, Geisen, Christoph, Li, Wenliang, Harlow, Ed, Kaelin, William G. Jr, Grueneberg, Dorre A

“…Clear cell renal carcinomas are the most common form of kidney cancer and frequently are linked to biallelic inactivation of the von Hippel-Lindau (VHL) tumor…”
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High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy by Gonzalez-Malerva, Laura, Park, Jaehong, Zou, Lihua, Hu, Yanhui, Moradpour, Zahra, Pearlberg, Joseph, Sawyer, Jacqueline, Stevens, Hallam, Harlow, Ed, LaBaer, Joshua

“…Resistance to tamoxifen in breast cancer patients is a serious therapeutic problem and major efforts are underway to understand underlying mechanisms…”
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GRK3 is essential for metastatic cells and promotes prostate tumor progression by Li, Wenliang, Ai, Nanping, Wang, Suming, Bhattacharya, Nandita, Vrbanac, Vladimir, Collins, Michael, Signoretti, Sabina, Hu, Yanhui, Boyce, Frederick M., Gravdal, Karsten, Halvorsen, Ole J., Nalwoga, Hawa, Akslen, Lars A., Ed Harlow, Watnick, Randolph S.

“…The biochemical mechanisms that regulate the process of cancer metastasis are still poorly understood. Because kinases, and the signaling pathways they…”
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Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis by Conery, Andrew R., Sever, Sanja, Harlow, Ed

“…Chromosomal instability and the subsequent genetic mutations are considered to be critical factors in the development of the majority of solid tumors. Here, we…”
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Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3 by Baldwin, Amy, Grueneberg, Dorre A., Hellner, Karin, Sawyer, Jacqueline, Grace, Miranda, Li, Wenliang, Harlow, Ed, Munger, Karl

“…Cervical carcinomas are initiated through a series of well-defined stages that rely on the expression of human papillomavirus (HPV) oncogenes. A panel of 100…”
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A-Type Lamins Regulate Retinoblastoma Protein Function by Promoting Subnuclear Localization and Preventing Proteasomal Degradation by Johnson, Brett R., Nitta, Ryan T., Frock, Richard L., Mounkes, Leslie, Barbie, David A., Stewart, Colin L., Harlow, Ed, Kennedy, Brian K.

“…The retinoblastoma protein (pRB) is a critical regulator of cell proliferation and differentiation and an important tumor suppressor. In the G1phase of the…”
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High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instability by Conery, Andrew R., Harlow, Ed

“…Chromosomal instability and the subsequent genetic mutations are considered to be critical factors in the development of the majority of solid tumors, but the…”
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Kinase requirements in human cells: I. Comparing kinase requirements across various cell types by Grueneberg, Dorre A, Degot, Sebastien, Pearlberg, Joseph, Li, Wenliang, Davies, Joan E, Baldwin, Amy, Endege, Wilson, Doench, John, Sawyer, Jacqueline, Hu, Yanhui, Boyce, Frederick, Xian, Jun, Munger, Karl, Harlow, Ed

“…shRNA loss-of-function screens were used to identify kinases that were rate-limiting for promoting cell proliferation and survival. Here, we study the…”
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Proteome-Scale Purification of Human Proteins from Bacteria by Braun, Pascal, Hu, Yanhui, Shen, Binghua, Halleck, Allison, Koundinya, Malvika, Harlow, Ed, LaBaer, Joshua

“…The completion of the human genome project and the development of high-throughput approaches herald a dramatic acceleration in the pace of biological research…”
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Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control by van den Heuvel, Sander, Harlow, Ed

“…The key cell-cycle regulator Cdc2 belongs to a family of cyclin-dependent kinases in higher eukaryotes. Dominant-negative mutations were used to address the…”
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Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells by Baldwin, Amy, Li, Wenliang, Grace, Miranda, Pearlberg, Joseph, Harlow, Ed, Münger, Karl, Grueneberg, Dorre A

“…Human papillomavirus (HPV) oncoproteins subvert cellular signaling pathways, including kinase pathways, during the carcinogenic process. To identify kinases…”
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Nuclear organization of DNA replication in primary mammalian cells by Kennedy, B K, Barbie, D A, Classon, M, Dyson, N, Harlow, E

“…Using methods that conserve nuclear architecture, we have reanalyzed the spatial organization of the initiation of mammalian DNA synthesis. Contrary to the…”
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Substrate Recruitment to Cyclin-Dependent Kinase 2 by a Multipurpose Docking Site on Cyclin A by Schulman, Brenda A., Lindstrom, Derek L., Harlow, Ed

“…An important question in the cell cycle field is how cyclin-dependent kinases (cdks) target their substrates. We have studied the role of a conserved…”
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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription by Zhao, J, Kennedy, B K, Lawrence, B D, Barbie, D A, Matera, A G, Fletcher, J A, Harlow, E

“…In eukaryotic cells, histone gene expression is one of the major events that mark entry into S phase. While this process is tightly linked to cell cycle…”
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Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines by Grueneberg, Dorre A, Li, Wenliang, Davies, Joan E, Sawyer, Jacqueline, Pearlberg, Joseph, Harlow, Ed

“…Functional differences among human cells have been difficult to identify by standard biochemical methods. Loss-of-function shRNA screens provide an unbiased…”
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Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1 by Yamasaki, Lili, Jacks, Tyler, Bronson, Roderick, Goillot, Evelyne, Harlow, Ed, Dyson, Nicholas J

“…The retinoblastoma tumor suppressor protein (pRB) is a transcriptional repressor that regulates gene expression by physically associating with transcription…”
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Opposing Roles of pRB and p107 in Adipocyte Differentiation by Classon, Marie, Kennedy, Brian K., Mulloy, Roseann, Harlow, Ed

“…The retinoblastoma (RB) family of proteins, pRB, p107, and p130, have been postulated to be partially redundant in their ability to regulate progression…”
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pRB Plays an Essential Role in Cell Cycle Arrest Induced by DNA Damage by Harrington, Elizabeth A., Bruce, Jacqueline L., Harlow, Ed, Dyson, Nicholas

“…To maintain genome stability, cells with damaged DNA must arrest to allow repair of mutations before replication. Although several key components required to…”
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