Search Results - "Harlfinger, S"

EFFECT OF PROPIVERINE ON CYTOCHROME P450 ENZYMES: A COCKTAIL INTERACTION STUDY IN HEALTHY VOLUNTEERS by Tomalik-Scharte, D, Jetter, A, Kinzig-Schippers, M, Skott, A, Sörgel, F, Klaassen, T, Kasel, D, Harlfinger, S, Doroshyenko, O, Frank, D, Kirchheiner, J, Bräter, M, Richter, K, Gramatté, T, Fuhr, U

“…The present study was conducted to assess a possible in vivo effect of propiverine, an anticholinergic drug to treat urinary incontinence and related…”
Get full text

Sensitive and convenient method for the quantification of clonidine in serum of pediatric patients using liquid chromatography/tandem mass spectrometry by Müller, C., Ramic, M., Harlfinger, S., Hünseler, C., Theisohn, M., Roth, B.

“…An improved and easy to use liquid chromatography/tandem mass spectrometric (LC/MS/MS) method in human serum was developed for the quantification of clonidine…”
Get full text

P25-14: Hepatic safety assessment of covalent inhibitor drug candidates by Amberntsson, S., Chouhan, B., Foster, A., Smith, G., Wilkinson, S., Harlfinger, S., Kavanagh, S., Williams, D.

Get full text

Discovery of the Ergothioneine Transporter by Gründemann, Dirk, Harlfinger, Stephanie, Golz, Stefan, Geerts, Andreas, Lazar, Andreas, Berkels, Reinhard, Jung, Norma, Rubbert, Andrea, Schömig, Edgar, Cerami, Anthony

“…Variants of the SLC22A4 gene are associated with susceptibility to rheumatoid arthritis and Crohn's disease. SLC22A4 codes for an integral membrane protein,…”
Get full text

Reproducibility of femtosecond laser incisions for posterior lamellar keratoplasty in vitro by Harlfinger, S, Langenbucher, A, Hofmann-Rummelt, C, Seitz, B

“…In the last decade surgeons have tried to use posterior lamellar keratoplasty (PLAK) in a way that maintains the biomechanical stability of the intact cornea…”
Get full text

Pharmacokinetics of clopidogrel after administration of a high loading dose by Taubert, Dirk, Kastrati, Adnan, Harlfinger, Steffi, Gorchakova, Olga, Lazar, Andreas, von Beckerath, Nicolas, Schömig, Albert, Schömig, Edgar

“…The adenosine diphosphate (ADP) receptor P2Y12 blocking agent clopidogrel is clinically proven to be efficient in preventing thrombotic events. However, its…”
Get more information

Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol by Schunk, Stefan, Linz, Klaus, Hinze, Claudia, Frormann, Sven, Oberbörsch, Stefan, Sundermann, Bernd, Zemolka, Saskia, Englberger, Werner, Germann, Tieno, Christoph, Thomas, Kögel, Babette-Y, Schröder, Wolfgang, Harlfinger, Stephanie, Saunders, Derek, Kless, Achim, Schick, Hans, Sonnenschein, Helmut

“…In a previous communication, our efforts leading from 1 to the identification of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amine 2a as analgesic NOP and…”
Get full text

Influence of Processing Parameters on Acrylamide Formation during Frying of Potatoes by Taubert, Dirk, Harlfinger, Steffi, Henkes, Liliane, Berkels, Reinhard, Schömig, Edgar

“…Consistent evidence suggests that the probable human carcinogen acrylamide is formed in starch-rich foodstuffs through heat-induced interaction of asparagine…”
Get full text

Discovery of Spiro[cyclohexane-dihydropyrano[3,4‑b]indole]-amines as Potent NOP and Opioid Receptor Agonists by Schunk, Stefan, Linz, Klaus, Frormann, Sven, Hinze, Claudia, Oberbörsch, Stefan, Sundermann, Bernd, Zemolka, Saskia, Englberger, Werner, Germann, Tieno, Christoph, Thomas, Kögel, Babette-Y, Schröder, Wolfgang, Harlfinger, Stephanie, Saunders, Derek, Kless, Achim, Schick, Hans, Sonnenschein, Helmut

“…We report the discovery of spiro[cyclohexane-pyrano[3,4-b]indole]-amines, as functional nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonists with…”
Get full text

Toxicokinetics of Acrylamide in Humans after Ingestion of a Defined Dose in a Test Meal to Improve Risk Assessment for Acrylamide Carcinogenicity by FUHR, Uwe, BOETTCHER, Melanie I, HARLFINGER, Stefanie, KLAASSEN, Tobias, BERKESSEL, Albrecht, ANGERER, Jiirgen, SBRGEL, Fritz, SCHÖMIG, Edgar, KINZIG-SCHIPPERS, Martina, WEYER, Alexandra, JETTER, Alexander, LAZAR, Andreas, TAUBED, Dirk, TOMALIK-SCHARTE, Dorota, POURNARA, Panagiota, JAKOB, Verena

“…High amounts of acrylamide in some foods result in an estimated daily mean intake of 50 μg for a western style diet. Animal studies have shown the…”
Get full text

Reaction rate constants of superoxide scavenging by plant antioxidants by Taubert, Dirk, Breitenbach, Thomas, Lazar, Andreas, Censarek, Petra, Harlfinger, Steffi, Berkels, Reinhard, Klaus, Wolfgang, Roesen, Renate

“…Plant phenols may exert protective effects by scavenging superoxide, which is implicated in tissue damage and accelerated inactivation of vasorelaxing nitric…”
Get full text

Further investigations into the genotoxicity of 2,6-xylidine and one of its key metabolites by Kirkland, David, Ballantyne, Mark, Harlfinger, Stefanie, Will, Olaf, Jahnel, Ulrich, Kraus, Alexander, Dorp, Corinne van

“…► Published data on the in vitro genotoxicity of 2,6-xylidine are inconsistent. ► Its key metabolite is probably dimethylphenyl N-hydroxylamine (DMHA). ►…”
Get full text

Quantification of cyclophosphamide and its metabolites in urine using liquid chromatography/tandem mass spectrometry by Kasel, Dirk, Jetter, Alexander, Harlfinger, Steffi, Gebhardt, Wilhelm, Fuhr, Uwe

“…A reliable and easy to use liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed for the simultaneous quantification of urinary…”
Get full text

Quantification of mephenytoin and its metabolites 4′-hydroxymephenytoin and nirvanol in human urine using a simple sample processing method by Klaassen, Tobias, Kasel, Dirk, Harlfinger, Stefanie, Fuhr, Uwe

“…A reliable and easy to use liquid chromatography/tandem mass spectrometry (LC/MS/MS) method without the use of sample extraction was developed for the…”
Get full text

Pharmacokinetics of piritramide in newborns, infants and young children in intensive care units by MÜLLER, Carsten, KREMER, Wolf, HARLFINGER, Steffi, DOROSHYENKO, Oxana, JETTER, Alexander, HERING, Fritz, HÜNSELER, Christoph, ROTH, Bernhard, THEISOHN, Martin

“…Piritramide is indicated for treatment of postoperative pain and analgosedation in the intensive care unit (ICU) setting. In an open prospective study the…”
Get full text

Are organic cation transporters capable of transporting prostaglandins? by Harlfinger, Stephanie, Fork, Christian, Lazar, Andreas, Schömig, Edgar, Gründemann, Dirk

“…The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and…”
Get full text

Reproduzierbarkeit der Femtosekundenlaserschnitte bei der posterioren lamellären Keratoplastik in vitro by Harlfinger, S., Langenbucher, A., Hofmann-Rummelt, C., Seitz, B.

“…Zusammenfassung Hintergrund und Ziele In der Korneachirurgie werden mittlerweile auch Techniken verwendet, in denen die Integrität des vorderen Hornhautstromas…”
Get full text