Search Results - "Harley, C B"

Reinforcement of Mono- and Bi-layer Poly(Ethylene Glycol) Hydrogels with a Fibrous Collagen Scaffold by Kinneberg, K. R. C., Nelson, A., Stender, M. E., Aziz, A. H., Mozdzen, L. C., Harley, B. A. C., Bryant, S. J., Ferguson, V. L.

“…Biomaterial-based tissue engineering strategies hold great promise for osteochondral tissue repair. Yet significant challenges remain in joining highly…”
Get full text

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT by Weinrich, Scott L, Pruzan, Ron, Ma, Libin, Ouellette, Michel, Tesmer, Valeric M, Holt, Shawn E, Bodnar, Andrea G, Lichtsteiner, Serge, Kim, Nam W, Trager, James B, Taylor, Rebecca D, Carlos, Ruben, Andrews, William H, Wright, Woodring E, Shay, Jerry W, Harley, Calvin B, Morin, Gregg B

“…The maintenance of chromosome termini, or telomeres, requires the action of the enzyme telomerase, as conventional DNA polymerases cannot fully replicate the…”
Get full text

Impact of the biophysical features of a 3D gelatin microenvironment on glioblastoma malignancy by Pedron, S., Harley, B. A. C.

“…Three‐dimensional tissue engineered constructs provide a platform to examine how the local extracellular matrix (ECM) contributes to the malignancy of cancers…”
Get full text

Telomerase activity in normal leukocytes and in hematologic malignancies by COUNTER, C. M, JYOTHI GUPTA, HARLEY, C. B, LEBER, B, BACCHETTI, S

“…Telomeres are essential for function and stability of eukaryotic chromosomes. In the absence of telomerase, the enzyme that synthesizes telomeric DNA,…”
Get full text

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells by Bodnar, Andrea G., Ouellette, Michel, Frolkis, Maria, Holt, Shawn E., Chiu, Choy-Pik, Morin, Gregg B., Harley, Calvin B., Shay, Jerry W., Lichsteiner, Serge, Wright, Woodring E.

“…Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative senescence. It has been proposed that…”
Get full text

Telomerase Activity in Human Ovarian Carcinoma by COUNTER, C. M, HIRTE, H. W, BACCHETTI, S, HARLEY, C. B

“…Telomeres fulfill the dual function of protecting eukaryotic chromosomes from illegitimate recombination and degradation and may aid in chromosome attachment…”
Get full text

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes by COUNTER, C. M, BOTELHO, F. M, PING WANG, HARLEY, C. B, BACCHETTI, S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Telomere Length and Replicative Aging in Human Vascular Tissues by Chang, Edwin, Harley, Calvin B.

“…Because repeated injury of the endothelium and subsequent turnover of intimal and medial cells have been implicated in atherosclerosis, we examined telomere…”
Get full text

Telomerase catalytic subunit homologs from fission yeast and human by Nakamura, T.M, Morin, G.B, Chapman, K.B, Weinrich, S.L, Andrews, W.H, Lingner, J, Harley, C.B, Cech, T.R

“…Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast Saccharomyces cerevisiae contain reverse transcriptase motifs…”
Get full text

Telomere Length Predicts Replicative Capacity of Human Fibroblasts by Allsopp, Richard C., Vaziri, Homayoun, Patterson, Christopher, Goldstein, Samuel, Younglai, Edward V., Futcher, A. Bruce, Greider, Carol W., Harley, Calvin B.

“…When human fibroblasts from different donors are grown in vitro, only a small fraction of the variation in their finite replicative capacity is explained by…”
Get full text

Relationship between permeability and diffusivity in polyethylene glycol hydrogels by Offeddu, G. S., Axpe, E., Harley, B. A. C., Oyen, M. L.

“…The transport properties of hydrogels largely affect their performance in biomedical applications ranging from cell culture scaffolds to drug delivery systems…”
Get full text

Evidence for a Mitotic Clock in Human Hematopoietic Stem Cells: Loss of Telomeric DNA with Age by Vaziri, Homayoun, Dragowska, Wieslawa, Allsopp, Richard C., Thomas, Terry E., Harley, Calvin B., Lansdorp, Peter M.

“…The proliferative life-span of the stem cells that sustain hematopoiesis throughout life is not known. It has been proposed that the sequential loss of…”
Get full text

The RNA Component of Human Telomerase by Feng, Junli, Funk, Walter D., Wang, Sy-Shi, Weinrich, Scott L., Avilion, Ariel A., Chiu, Choy-Pik, Adams, Robert R., Chang, Edwin, Allsopp, Richard C., Yu, Jinghua, Le, Siyuan, West, Michael D., Harley, Calvin B., Andrews, William H., Greider, Carol W., Villeponteau, Bryant

“…Eukaryotic chromosomes are capped with repetitive telomere sequences that protect the ends from damage and rearrangements. Telomere repeats are synthesized by…”
Get full text

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer by Kim, Nam W., Piatyszek, Mieczyslaw A., Prowse, Karen R., Harley, Calvin B., West, Michael D., Peter L. C. Ho, Coviello, Gina M., Wright, Woodring E., Weinrich, Scott L., Shay, Jerry W.

“…Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring…”
Get full text

Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase by LUDWIG, Antje, SARETZKI, Gabriele, HOLM, Per S, TIEMANN, Frank, LORENZ, Mario, EMRICH, Thomas, HARLEY, Calvin B, VON ZGLINICKI, Thomas

“…Telomerase activity is necessary and sufficient for immortality in many cells and hence represents a prime target for antitumor strategies. Here, we show that…”
Get full text

Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen by JINDAL, S, DUDANI, A. K, SINGH, B, HARLEY, C. B, GUPTA, R. S

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis by Effros, R B, Allsopp, R, Chiu, C P, Hausner, M A, Hirji, K, Wang, L, Harley, C B, Villeponteau, B, West, M D, Giorgi, J V

“…To test the hypothesis that the expanded population of non-proliferative CD28-CD8+ T cells in HIV disease have shortened telomeres, thereby providing evidence…”
Get more information

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes by VAZIRI, H, SCHÄCHTER, F, UCHIDA, I, LAN WEI, XIAOMING ZHU, EFFROS, R, COHEN, D, HARLEY, C. B

“…The telomere hypothesis of cellular aging proposes that loss of telomeric DNA (TTAGGG) from human chromosomes may ultimately cause cell-cycle exit during…”
Get full text

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity by Counter, C.M., Avilion, A.A., LeFeuvre, C.E., Stewart, N.G., Greider, C.W., Harley, C.B., Bacchetti, S.

“…Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication of eukaryotic chromosomes and…”
Get full text

Telomeres shorten during ageing of human fibroblasts by Harley, Calvin B, Futcher, A. Bruce, Greider, Carol W

“…The terminus of a DNA helix has been called its Achilles' heel. Thus to prevent possible incomplete replication and instability of the termini of linear DNA,…”
Get full text