Search Results - "Harley, Benjamin Kingsley"
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Bioactive triterpenoids from Solanum torvum fruits with antifungal, resistance modulatory and anti-biofilm formation activities against fluconazole-resistant candida albicans strains
Published in PloS one (28-12-2021)“…Vulvovaginal candidiasis (VVC) is the second most common vaginal infection that affects women of reproductive age. Its increased occurrence and associated…”
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Metabolite profiling, antifungal, biofilm formation prevention and disruption of mature biofilm activities of Erythrina senegalensis stem bark extract against Candida albicans and Candida glabrata
Published in PloS one (28-11-2022)“…The antifungal activity of the 70% ethanol stem bark extract of Erythrina senegalensis (ESB) against different strains and drug resistant clinical isolates of…”
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3
Fast-onset effects of Pseudospondias microcarpa (A. Rich) Engl. (Anacardiaceae) hydroethanolic leaf extract on behavioral alterations induced by chronic mild stress in mice
Published in PloS one (02-02-2023)“…Pseudospondias microcarpa (Anacardiaceae) is a plant widely used traditionally for treating various central nervous system disorders. A previous study in our…”
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Pyridine-N-Oxide Alkaloids from Allium stipitatum and Their Synthetic Disulfide Analogs as Potential Drug Candidates against Mycobacterium tuberculosis: A Molecular Docking, QSBAR, and ADMET Prediction Approach
Published in BioMed research international (07-10-2022)“…In this study, we consider pyridine-N-oxide alkaloids from Allium stipitatum and their synthetic disulfide analogs (PDAs) as candidates for next-generational…”
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Metabolite profiling, antifungal, biofilm formation prevention and disruption of mature biofilm activities of Erythrina senegalensis stem bark extract against Candida albicans and Candida glabrata
Published in PloS one (28-11-2022)“…The antifungal activity of the 70% ethanol stem bark extract of Erythrina senegalensis (ESB) against different strains and drug resistant clinical isolates of…”
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6
Flavanols and triterpenoids from Myrianthus arboreus ameliorate hyperglycaemia in streptozotocin-induced diabetic rats possibly via glucose uptake enhancement and α-amylase inhibition
Published in Biomedicine & pharmacotherapy (01-12-2020)“…[Display omitted] •Dulcisflavan (compound 3) from M. arboreus stem bark alleviates hyperglycaemia and hyperlipidaemia in streptozotocin-induced diabetic…”
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Myrianthus libericus: Possible mechanisms of hypoglycaemic action and in silico prediction of pharmacokinetics and toxicity profile of its bioactive metabolite, friedelan-3-one
Published in Biomedicine & pharmacotherapy (01-05-2021)“…The hypoglycaemic and anti-hyperlipidaemic effects of the 70% ethanol stem bark extract of Myrianthus libericus (MLB), used traditionally in the management of…”
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In Vivo Antiplasmodial Activity of Different Solvent Extracts of Myrianthus libericus Stem Bark and Its Constituents in Plasmodium berghei-Infected Mice
Published in Evidence-based complementary and alternative medicine (2020)“…The emergence and resurgence of P. falciparum resistance to generations of antimalarial drugs have prompted the search for new, effective, and safe…”
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Hypoglycaemic activity of Oleanonic acid, a 3-oxotriterpenoid isolated from Aidia Genipiflora (DC.) Dandy, involves inhibition of carbohydrate metabolic enzymes and promotion of glucose uptake
Published in Biomedicine & pharmacotherapy (01-05-2022)“…The present study evaluated the antidiabetic activities of the 70% ethanol stem bark extract of Aidia genipiflora (AGB) and one of its constituents, oleanonic…”
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Antifungal Activities of Phytochemically Characterized Hydroethanolic Extracts of Sclerocarya birrea Leaves and Stem Bark against Fluconazole-Resistant Candida albicans Strains
Published in BioMed research international (2022)“…The study evaluated the antifungal activities of the 70% ethanol extracts of Sclerocarya birrea leaves (SBL) and stem bark (SBB) against C. albicans strains…”
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Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria
Published in Heteroatom chemistry (26-09-2022)“…A library of six compounds with new hybrids in a single molecule triazole ring attached to the phosphonium salts was synthesized. Click chemistry was, however,…”
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Evaluation of the anti-inflammatory and antioxidant potential of the stem bark extract and some constituents of Aidia genipiflora (DC.) dandy (rubiaceae)
Published in Heliyon (01-08-2022)“…Aidia genipiflora (DC.) Dandy (Rubiaceae) is used to treat various microbial and inflammatory conditions by traditional healers in West African countries…”
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Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways
Published in Natural products and bioprospecting (01-12-2023)“…Pseudospondias microcarpa is used in ethnomedicine to manage central nervous system diseases. The hydroethanolic extract (PME) from the leaves of the plant has…”
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Effect of Trichilia monadelpha (Thonn.) J. J. de Wilde (Meliaceae) extracts on C-reactive proteins levels and acute inflammation
Published in Scientific African (01-07-2022)“…Trichilia monadelpha is reported to have acute anti-inflammatory effects. This study sought to establish the possible effects of the petroleum ether, ethyl…”
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Antidiabetic effect of Chrysophyllum albidum is mediated by enzyme inhibition and enhancement of glucose uptake via 3T3-L1 adipocytes and C2C12 myotubes
Published in Asian Pacific journal of tropical biomedicine (01-09-2020)“…Objective: To investigate the in vivo and in vitro antidiabetic potential of Chrysophyllum albidum. Methods: The effects of oral treatment with hydro-ethanolic…”
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Fruits of Vitex doniana sweet: toxicity profile, anti-inflammatory and antioxidant activities, and quantification of one of its bioactive constituents oleanolic acid
Published in Heliyon (01-09-2021)“…Vitex doniana Sweet fruit, an under-utilised crop specie of Ghana, has not been validated for its ethnomedical use in managing inflammatory conditions…”
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Assessment of some quality parameters and chemometric-assisted FTIR spectral analysis of commercial powdered ginger products on the Ghanaian market
Published in Heliyon (01-03-2022)“…Zingiber officinale Roscoe (ginger) rhizome is a global spice with marked pharmacological activities and industrial applications. The demand for the powdered…”
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Synthesis, molecular docking studies and ADME prediction of some new triazoles as potential antimalarial agents
Published in Scientific African (01-11-2021)“…•A library of seven compounds have been synthesised using click reaction via 1,3-dipolar cycloaddition.•Compounds 3a-d were significantly active against the…”
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Anti-mycobacterium ulcerans activity and pharmacognostic standardisation of Pycnanthus angolensis (Welw) Warb
Published in Scientific African (01-09-2021)“…Buruli ulcer disease, a necrotising skin and subcutaneous tissue disease, is endemic to tropical Africa. People in endemic communities’ resort to topical and…”
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Antimicrobial and Biofilm Formation Inhibition Properties of Biogenic Silver Nanoparticles Synthesised Using Tuber Extract of Cyperus esculentus
Published in BioNanoScience (01-03-2023)“…The use of silver nanoparticles obtained by the green synthesis approach in the field of nanomedicine is on the rise. Therefore, it is imperative to search for…”
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