Search Results - "Harlander, Sabine"

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice by Hoefflin, Rouven, Harlander, Sabine, Schäfer, Silvia, Metzger, Patrick, Kuo, Fengshen, Schönenberger, Désirée, Adlesic, Mojca, Peighambari, Asin, Seidel, Philipp, Chen, Chia-yi, Consenza-Contreras, Miguel, Jud, Andreas, Lahrmann, Bernd, Grabe, Niels, Heide, Danijela, Uhl, Franziska M., Chan, Timothy A., Duyster, Justus, Zeiser, Robert, Schell, Christoph, Heikenwalder, Mathias, Schilling, Oliver, Hakimi, A. Ari, Boerries, Melanie, Frew, Ian J.

“…Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal cell carcinomas (ccRCC), leading to accumulation of the HIF-1α…”
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Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice by Harlander, Sabine, Schönenberger, Désirée, Toussaint, Nora C, Prummer, Michael, Catalano, Antonella, Brandt, Laura, Moch, Holger, Wild, Peter J, Frew, Ian J

“…Through combined deletion of Vhl , Trp53 and Rb1 in renal epithelial cells, the authors develop a new mouse model of renal cell carcinoma that recapitulates…”
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Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells by Gonçalves, Ana Filipa, Adlesic, Mojca, Brandt, Simone, Hejhal, Tomas, Harlander, Sabine, Sommer, Lukas, Shakhova, Olga, Wild, Peter J., Frew, Ian J.

“…Renal angiomyolipomas (AML) contain an admixture of clonal tumour cells with features of several different mesenchymal lineages, implying the existence of an…”
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Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice by Albers, Joachim, Rajski, Michal, Schönenberger, Désirée, Harlander, Sabine, Schraml, Peter, von Teichman, Adriana, Georgiev, Strahil, Wild, Peter J., Moch, Holger, Krek, Wilhelm, Frew, Ian J.

“…The combinations of genetic alterations that cooperate with von Hippel–Lindau ( VHL ) mutation to cause clear cell renal cell carcinoma (ccRCC) remain poorly…”
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Chicken Ovalbumin Upstream Promoter Transcription Factor II Regulates Renin Gene Expression by Mayer, Sandra, Roeser, Marc, Lachmann, Peter, Ishii, Sumiyashi, Suh, Jae Mi, Harlander, Sabine, Desch, Michael, Brunssen, Coy, Morawietz, Henning, Tsai, Sophia Y., Tsai, Ming-Jer, Hohenstein, Bernd, Hugo, Christian, Todorov, Vladimir T.

“…This study aimed to investigate the possible involvement of the orphan nuclear receptor chicken ovalbumin upstream promoter transcription factor II (COUP-TFII)…”
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Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α by Schönenberger, Désirée, Harlander, Sabine, Rajski, Michal, Jacobs, Robert A, Lundby, Anne-Kristine, Adlesic, Mojca, Hejhal, Tomas, Wild, Peter J, Lundby, Carsten, Frew, Ian J

“…The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in the majority of clear cell renal cell carcinomas (ccRCC), but genetic ablation of Vhl alone…”
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Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis by Schönenberger, Désirée, Rajski, Michal, Harlander, Sabine, Frew, Ian J

“…One of the earliest requirements for the formation of a solid tumor is the establishment of an adequate blood supply. Clear cell renal cell carcinomas (ccRCC)…”
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Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice by Harlander, Sabine, Schönenberger, Désirée, Toussaint, Nora C., Prummer, Michael, Catalano, Antonella, Brandt, Laura, Moch, Holger, Wild, Peter J., Frew, Ian J.

“…Clear cell renal cell carcinomas (ccRCC) frequently exhibit inactivation of the VHL tumour suppressor gene and often harbour multiple copy number alterations…”
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Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma by Hoefflin, Rouven, Harlander, Sabine, Abhari, Behnaz A., Peighambari, Asin, Adlesic, Mojca, Seidel, Philipp, Zodel, Kyra, Haug, Stefan, Göcmen, Burulca, Li, Yong, Lahrmann, Bernd, Grabe, Niels, Heide, Danijela, Boerries, Melanie, Köttgen, Anna, Heikenwalder, Mathias, Frew, Ian J.

“…Specific inhibitors of HIF-2α have recently been approved for the treatment of ccRCC in VHL disease patients and have shown encouraging results in clinical…”
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cAMP target sequences enhCRE and CNRE sense low-salt intake to increase human renin gene expression in vivo by Desch, Michael, Harlander, Sabine, Neubauer, Björn, Gerl, Melanie, Germain, Stephane, Castrop, Hayo, Todorov, Vladimir T.

“…This study aimed to assess the role of cAMP target sequences enhancer cAMP response element (enhCRE) and cAMP and overlapping negative response element (CNRE)…”
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Renin gene expression is regulated by Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP‐TF II) by Lachmann, Peter, Mayer, Sandra, Roeser, Marc, Ishii, Sumiyashi, Suh, Jae Mi, Harlander, Sabine, Desch, Michael, Brunßen, Coy, Morawietz, Henning, Tsai, Sophia Y., Tsai, Ming‐Jer, Hohenstein, Bernd, Hugo, Christian, Todorov, Vladimir T.

“…Abstract only We aimed to investigate the involvement of the nuclear receptor COUP‐TFII in the regulation of renin gene expression. Protein‐DNA binding studies…”
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