Search Results - "Harlan, DM"

The Future of Organ and Tissue Transplantation: Can T-Cell Costimulatory Pathway Modifiers Revolutionize the Prevention of Graft Rejection? by Harlan, David M, Kirk, Allan D

“…Transplantation therapies have revolutionized care for patients with end-stage organ (kidney, liver, heart, lung, and pancreatic β-cell) failure, yet…”
Get full text

A Single Course of Anti-CD3 Monoclonal Antibody hOKT3 gamma 1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes by Herold, Kevan C, Gitelman, Stephen E, Masharani, Umesh, Hagopian, William, Bisikirska, Brygida, Donaldson, David, Rother, Kristina, Diamond, Beverly, Harlan, David M, Bluestone, Jeffrey A

“…Despite advances in understanding autoimmune diabetes in animal models, there has been little progress in altering the natural course of the human disease,…”
Get full text

Assessment of Human Pancreatic Islet Architecture and Composition by Laser Scanning Confocal Microscopy by Brissova, Marcela, Fowler, Michael J, Nicholson, Wendell E, Chu, Anita, Hirshberg, Boaz, Harlan, David M, Powers, Alvin C

“…The recent success of pancreatic islet transplantation has generated considerable enthusiasm. To better understand the quality and characteristics of human…”
Get full text

Glucagon-Like Peptide 1 Inhibits Cell Apoptosis and Improves Glucose Responsiveness of Freshly Isolated Human Islets by Farilla, Loredana, Bulotta, Angela, Hirshberg, Boaz, Li Calzi, Sergio, Khoury, Nasif, Noushmehr, Houtan, Bertolotto, Cristina, Di Mario, Umberto, Harlan, David M, Perfetti, Riccardo

“…The peptide hormone, glucagon-like peptide 1 (GLP-1), has been shown to increase glucose-dependent insulin secretion, enhance insulin gene transcription,…”
Get full text

Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus by Herold, Kevan C, Hagopian, William, Auger, Julie A, Poumian-Ruiz, Ena, Taylor, Lesley, Donaldson, David, Gitelman, Stephen E, Harlan, David M, Xu, Danlin, Zivin, Robert A, Bluestone, Jeffrey A

“…Mechanisms that destroy beta cells in type 1 diabetes mellitus involve both cytotoxic T cells and soluble T-cell products. In the present study, 24 patients…”
Get full text

Survival After Pancreas Transplantation in Patients With Diabetes and Preserved Kidney Function by Venstrom, Jeffrey M, McBride, Maureen A, Rother, Kristina I, Hirshberg, Boaz, Orchard, Trevor J, Harlan, David M

“…CONTEXT Solitary pancreas transplantation (ie, pancreas alone or pancreas-after-kidney) for diabetes mellitus remains controversial due to procedure-associated…”
Get full text

Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (Campath-1H) by KIRK, Allan D, HALE, Douglas A, MANNON, Roslyn B, KLEINER, David E, HOFFMANN, Steven C, KAMPEN, Robert L, CENDALES, Linda K, TADAKI, Douglas K, HARLAN, David M, SWANSON, S. John

“…Profound T-cell depletion before allotransplantation with gradual posttransplant T-cell repopulation induces a state of donor-specific immune…”
Get full text

Ethnicity Greatly Influences Cytokine Gene Polymorphism Distribution by Hoffmann, Steven C., Stanley, Eran M., Cox, E. Darrin, DiMercurio, Barbara S., Koziol, Deloris E., Harlan, David M., Kirk, Allan D., Blair, Patrick J.

“…Polymorphisms in the regulatory regions of cytokine genes are associated with high and low cytokine production and may modulate the magnitude of alloimmune…”
Get full text

Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes by HOFFMANN, Steven C, STANLEY, Eran M, COX, E. Darrin, CRAIGHEAD, Nancy, DIMERCURIO, Barbara S, KOZIOL, Deloris E, HARLAN, David M, KIRK, Allan D, BLAIR, Patrick J

“…Genetic variations in cytokine genes are thought to regulate cytokine protein production. However, studies using T cell mitogens have not always demonstrated a…”
Get full text

Oligonucleotide Microarray Analysis of Intact Human Pancreatic Islets: Identification of Glucose-Responsive Genes and a Highly Regulated TGFβ Signaling Pathway by Shalev, Anath, Pise-Masison, Cynthia A, Radonovich, Michael, Hoffmann, Steven C, Hirshberg, Boaz, Brady, John N, Harlan, David M

“…Human pancreatic islets are a major focus of diabetes research due to their key role in glucose homeostasis and their potential for transplantation in the…”
Get full text

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates by Kirk, Allan D, Burkly, Linda C, Batty, D. Scott, Baumgartner, Roxanne E, Berning, Justin D, Buchanan, Kelvin, Fechner, John H, Germond, Rhonda L, Kampen, Robert L, Patterson, Noelle B, Swanson, S. John, Tadaki, Douglas K, TenHoor, Christopher N, White, Leonard, Knechtle, Stuart J, Harlan, David M

“…CD154 is the ligand for the receptor CD40. This ligand-receptor pair mediates endothelial and antigen-presenting cell activation, and facilitates the…”
Get full text

Insulin Secretion in Type 1 Diabetes by STEELE, Chynna, HAGOPIAN, William A, GITELMAN, Stephen, MASHARANI, Umesh, CAVAGHAN, Melissa, ROTHER, Kristina I, DONALDSON, David, HARLAN, David M, BLUESTONE, Jeffrey, HEROLD, Kevan C

“…Insulin Secretion in Type 1 Diabetes Chynna Steele 1 , William A. Hagopian 2 , Stephen Gitelman 3 , Umesh Masharani 3 , Melissa Cavaghan 4 , Kristina I. Rother…”
Get full text

Long-Term Survival and Function of Intrahepatic Islet Allografts in Rhesus Monkeys Treated with Humanized Anti-CD154 by Kenyon, Norma S., Chatzipetrou, Maria, Masetti, Michele, Ranuncoli, Alessandra, Oliveira, Maria, Wagner, Joseph L., Kirk, Allan D., Harlan, David M., Burkly, Linda C., Ricordi, Camillo

“…Reported effects of anti-CD154 treatment on autoimmunity, alloreactivity, and inflammatory events mediated by macrophages and endothelial cells indicated that…”
Get full text

Benefits and Risks of Solitary Islet Transplantation for Type 1 Diabetes Using Steroid-Sparing Immunosuppression by HIRSHBERG, Boaz, ROTHER, Kristina I, DIGON, Benigno J, LEE, Janet, GAGLIA, Jason L, HINES, Kenneth, READ, Elizabeth J, CHANG, Richard, WOOD, Bradford J, HARLAN, David M

“…Benefits and Risks of Solitary Islet Transplantation for Type 1 Diabetes Using Steroid-Sparing Immunosuppression The National Institutes of Health experience…”
Get full text

Resistin is expressed in pancreatic islets by Minn, Alexandra H, Patterson, Noelle B, Pack, Stephanie, Hoffmann, Steven C, Gavrilova, Oksana, Vinson, Charles, Harlan, David M, Shalev, Anath

“…Resistin, a recently described adipocyte factor, is regulated by peroxisome proliferator-activated receptor gamma (PPARγ) agonists. While resistin has been…”
Get full text

Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6 by COX, E. Darrin, HOFFMANN, Steven C, DIMERCURIO, Barbara S, WESLEY, Robert A, HARLAN, David M, KIRK, Allan D, BLAIR, Patrick J

“…Polymorphisms in the regulatory regions of cytokine genes affect protein production and are associated with allograft outcome. Ethnic origin has been…”
Get full text

Pancreatic islet transplantation by Naftanel, Mark A, Harlan, David M

“…Islet transplantation offers hope to many patients with diabetes, who envision a life free of glucose checks and insulin injections. What are the barriers to…”
Get full text

Assessment of pancreatic islet mass after islet transplantation using in vivo bioluminescence imaging by FOWLER, Michael, VIROSTKO, John, HARLAN, David M, DUCO JANSEN, E, POWERS, Alvin C, ZHONGYI CHEN, POFFENBERGER, Greg, RADHIKA, Aramandia, BRISSOVA, Marcela, SHIOTA, Masakazu, NICHOLSON, Wendell E, YUBIN SHI, HIRSHBERG, Boaz

“…Pancreatic islet transplantation is an emerging therapy for type 1 diabetes, but it is difficult to assess islets after transplantation and thus to design…”
Get full text

Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy by Swanson, S John, Hale, Douglas A, Mannon, Roslyn B, Kleiner, David E, Cendales, Linda C, Chamberlain, Christine E, Polly, Shirley M, Harlan, David M, Kirk, Allan D

“…Renal allograft recipients generally need to take several immunosuppressive agents for life. Calcineurin inhibitors and glucocorticosteroids are the mainstays…”
Get full text

mRNA analysis of intracytoplasmically-stained, FACS-purified pancreatic islet cells using the quantitative nuclease protection assay by Pechhold, S, Stouffer, M, Walker, G, Martel, R, Seligmann, B, Hang, Y, Stein, R, Harlan, DM, Pechhold, K

“…Exploring the pathophysiology underlying diabetes mellitus requires characterizing the cellular constituents of pancreatic islets, primarily insulin-producing…”
Get full text