Search Results - "Harlan, D M"

Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined by in Vivo Thymidine Analog Incorporation and Radiocarbon Dating by Perl, S, Kushner, J. A, Buchholz, B. A, Meeker, A. K, Stein, G. M, Hsieh, M, Kirby, M, Pechhold, S, Liu, E. H, Harlan, D. M, Tisdale, J. F

“…Aims: Diabetes mellitus results from an absolute or relative deficiency of insulin-producing pancreatic β-cells. The turnover rate of adult human β-cells…”
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Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft by Liu, E. H, Digon, B. J. III, Hirshberg, B, Chang, R, Wood, B. J, Neeman, Z, Kam, A, Wesley, R. A, Polly, S. M, Hofmann, R. M, Rother, K. I, Harlan, D. M

“…Aims/hypothesis We measured serum C-peptide (at least 0.167 nmol/l) in 54 of 141 (38%) patients with chronic type 1 diabetes and sought factors that might…”
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Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154 by KENYON, N. S, FERNANDEZ, L. A, BERHO, M, INVERARDI, L, ALEJANDRO, R, MINTZ, D. H, KIRK, A. D, HARLAN, D. M, BURKLY, L. C, RICORDI, C, LEHMANN, R, MASETTI, M, RANUNCOLI, A, CHATZIPETROU, M, IARIA, G, HAN, D, WAGNER, J. L, RUIZ, P

“…Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154. N S Kenyon , L A Fernandez , R Lehmann , M…”
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Long-Term Survival and Function of Intrahepatic Islet Allografts in Rhesus Monkeys Treated with Humanized Anti-CD154 by Kenyon, Norma S., Chatzipetrou, Maria, Masetti, Michele, Ranuncoli, Alessandra, Oliveira, Maria, Wagner, Joseph L., Kirk, Allan D., Harlan, David M., Burkly, Linda C., Ricordi, Camillo

“…Reported effects of anti-CD154 treatment on autoimmunity, alloreactivity, and inflammatory events mediated by macrophages and endothelial cells indicated that…”
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How much insulin is enough? A quantitative assessment of the transdifferentiaton potential of liver by PERL, S, HIRSHBERG, B, HARLAN, D. M, TISDALE, J. F

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The Future of Organ and Tissue Transplantation: Can T-Cell Costimulatory Pathway Modifiers Revolutionize the Prevention of Graft Rejection? by Harlan, David M, Kirk, Allan D

“…Transplantation therapies have revolutionized care for patients with end-stage organ (kidney, liver, heart, lung, and pancreatic β-cell) failure, yet…”
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The role of CD154 in organ transplant rejection and acceptance by Kirk, Allan D., Blair, Patrick J., Tadaki, Douglas K., Xu, He, Harlan, David M.

“…CD154 plays a critical role in determining the outcome of a transplanted organ. This simple statement is amply supported by experimental evidence demonstrating…”
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Mice Expressing Both B7-1 and Viral Glycoprotein on Pancreatic Beta Cells Along with Glycoprotein-Specific Transgenic T Cells Develop Diabetes Due to a Breakdown of T-Lymphocyte Unresponsiveness by HARLAN, D. M, HENGARTNER, H, NADLER, L. M, JUNE, C. H, AICHELE, P, HUANG, M. L, YUAN-HSU KANG, ABE, R, MOREDITH, R. W, PIRCHER, H, GRAY, G. S, OHASHI, P. S, FREEMAN, G. J

“…T lymphocytes have been implicated in the onset of many autoimmune diseases; however, the mechanisms underlying T-cell activation toward self antigens are…”
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Long‐Term Immunosuppression After Solitary Islet Transplantation Is Associated With Preserved C‐Peptide Secretion for More Than a Decade by Blau, J. E., Abegg, M. R., Flegel, W. A., Zhao, X., Harlan, D. M., Rother, K. I.

“…We report on two patients with type 1 diabetes (T1D) after solitary islet transplantation in 2001. They received steroid‐sparing immunosuppression (daclizumab,…”
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Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (Campath-1H) by KIRK, Allan D, HALE, Douglas A, MANNON, Roslyn B, KLEINER, David E, HOFFMANN, Steven C, KAMPEN, Robert L, CENDALES, Linda K, TADAKI, Douglas K, HARLAN, David M, SWANSON, S. John

“…Profound T-cell depletion before allotransplantation with gradual posttransplant T-cell repopulation induces a state of donor-specific immune…”
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Low Dose Streptozotocin-Induced Diabetes in Rat Insulin Promoter-mCD80-Transgenic Mice Is T Cell Autoantigen-Specific and CD28 Dependent by Pechhold, Klaus, Patterson, Noelle B, Blum, Carmen, Fleischacker, Christine L, Boehm, Bernhard O, Harlan, David M

“…Although transgenic mice expressing murine B7-1 (mCD80) on their pancreatic beta cells under the rat insulin-1 promoter (RIP-mCD80(+) mice) rarely develop…”
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IGRP and insulin vaccination induce CD8+ T cell‐mediated autoimmune diabetes in the RIP‐CD80GP mouse by Fuchs, Y. F., Adler, K., Lindner, A., Karasinsky, A., Wilhelm, C., Weigelt, M., Balke, H., Förtsch, K., Mortler‐Hildebrandt, L. F., Harlan, D. M., Pechhold, K., Ziegler, A.‐G., Bonifacio, E.

“…Summary Autoimmune diabetes is characterized by autoantigen‐specific T cell‐mediated destruction of pancreatic islet beta cells, and CD8+ T cells are key…”
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Protection against lethal toxic shock by targeted disruption of the CD28 gene by Saha, B, Harlan, D M, Lee, K P, June, C H, Abe, R

“…Toxic shock syndrome (TSS) is a multi system disorder resulting from superantigen-mediated cytokine production. Nearly 90% of the clinical cases of TSS arise…”
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Ethnicity Greatly Influences Cytokine Gene Polymorphism Distribution by Hoffmann, Steven C., Stanley, Eran M., Cox, E. Darrin, DiMercurio, Barbara S., Koziol, Deloris E., Harlan, David M., Kirk, Allan D., Blair, Patrick J.

“…Polymorphisms in the regulatory regions of cytokine genes are associated with high and low cytokine production and may modulate the magnitude of alloimmune…”
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Primate skin allotransplantation with anti-CD154 monotherapy by Elster, E.A, Xu, H, Tadaki, D.K, Burkly, L.C, Berning, J.D, Baumgartner, R.E, Cruzata, F, Patterson, N.B, Harlan, D.M, Kirk, A.D

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Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes by HOFFMANN, Steven C, STANLEY, Eran M, COX, E. Darrin, CRAIGHEAD, Nancy, DIMERCURIO, Barbara S, KOZIOL, Deloris E, HARLAN, David M, KIRK, Allan D, BLAIR, Patrick J

“…Genetic variations in cytokine genes are thought to regulate cytokine protein production. However, studies using T cell mitogens have not always demonstrated a…”
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The human myristoylated alanine-rich C kinase substrate (MARCKS) gene (MACS). Analysis of its gene product, promoter, and chromosomal localization by D M Harlan, J M Graff, D J Stumpo, R L Eddy, Jr, T B Shows, J M Boyle, P J Blackshear

“…The expression of a major cellular substrate for protein kinase C, the MARCKS protein, is regulated in a cell-, tissue-, and developmental stage-specific…”
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Low Dose Poly I:C Prevents Diabetes in the Diabetes Prone BB Rat by Sobel, Douglas O, Goyal, Deepshika, Ahvazi, Behrouz, Yoon, Ji-Won, Chung, Young Hwa, Bagg, Adam, Harlan, David M

“…Poly I:C, an inducer of IFN-α and other cytokines, has been used to study the development of diabetes in both the BioBreeding (BB) diabetes prone rat and…”
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Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates by Kirk, Allan D, Burkly, Linda C, Batty, D. Scott, Baumgartner, Roxanne E, Berning, Justin D, Buchanan, Kelvin, Fechner, John H, Germond, Rhonda L, Kampen, Robert L, Patterson, Noelle B, Swanson, S. John, Tadaki, Douglas K, TenHoor, Christopher N, White, Leonard, Knechtle, Stuart J, Harlan, David M

“…CD154 is the ligand for the receptor CD40. This ligand-receptor pair mediates endothelial and antigen-presenting cell activation, and facilitates the…”
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Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand by Knechtle, S.J, Kirk, A.D, Fechner, J.H, Hong, X, Dong, Y, Hamawy, M.M, Harlan, D.M

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