Search Results - "Harkness, Elaine F."

Schwannomatosis: a genetic and epidemiological study by Evans, D Gareth, Bowers, Naomi L, Tobi, Simon, Hartley, Claire, Wallace, Andrew J, King, Andrew T, Lloyd, Simon K W, Rutherford, Scott A, Hammerbeck-Ward, Charlotte, Pathmanaban, Omar N, Freeman, Simon R, Ealing, John, Kellett, Mark, Laitt, Roger, Thomas, Owen, Halliday, Dorothy, Ferner, Rosalie, Taylor, Amy, Duff, Chris, Harkness, Elaine F, Smith, Miriam J

“…ObjectivesSchwannomatosis is a dominantly inherited condition predisposing to schwannomas of mainly spinal and peripheral nerves with some diagnostic overlap…”
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Mammographic density adds accuracy to both the Tyrer-Cuzick and Gail breast cancer risk models in a prospective UK screening cohort by Brentnall, Adam R, Harkness, Elaine F, Astley, Susan M, Donnelly, Louise S, Stavrinos, Paula, Sampson, Sarah, Fox, Lynne, Sergeant, Jamie C, Harvie, Michelle N, Wilson, Mary, Beetles, Ursula, Gadde, Soujanya, Lim, Yit, Jain, Anil, Bundred, Sara, Barr, Nicola, Reece, Valerie, Howell, Anthony, Cuzick, Jack, Evans, D Gareth R

“…The Predicting Risk of Cancer at Screening study in Manchester, UK, is a prospective study of breast cancer risk estimation. It was designed to assess whether…”
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A comparison of five methods of measuring mammographic density: a case-control study by Astley, Susan M, Harkness, Elaine F, Sergeant, Jamie C, Warwick, Jane, Stavrinos, Paula, Warren, Ruth, Wilson, Mary, Beetles, Ursula, Gadde, Soujanya, Lim, Yit, Jain, Anil, Bundred, Sara, Barr, Nicola, Reece, Valerie, Brentnall, Adam R, Cuzick, Jack, Howell, Tony, Evans, D Gareth

“…High mammographic density is associated with both risk of cancers being missed at mammography, and increased risk of developing breast cancer. Stratification…”
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A novel and fully automated mammographic texture analysis for risk prediction: results from two case-control studies by Wang, Chao, Brentnall, Adam R, Cuzick, Jack, Harkness, Elaine F, Evans, D Gareth, Astley, Susan

“…The percentage of mammographic dense tissue (PD) is an important risk factor for breast cancer, and there is some evidence that texture features may further…”
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Use of Single-Nucleotide Polymorphisms and Mammographic Density Plus Classic Risk Factors for Breast Cancer Risk Prediction by van Veen, Elke M, Brentnall, Adam R, Byers, Helen, Harkness, Elaine F, Astley, Susan M, Sampson, Sarah, Howell, Anthony, Newman, William G, Cuzick, Jack, Evans, D Gareth R

“…Single-nucleotide polymorphisms (SNPs) have demonstrated an association with breast cancer susceptibility, but there is limited evidence on how to incorporate…”
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What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420) by French, David P, Astley, Susan, Brentnall, Adam R, Cuzick, Jack, Dobrashian, Richard, Duffy, Stephen W, Gorman, Louise S, Harkness, Elaine F, Harrison, Fiona, Harvie, Michelle, Howell, Anthony, Jerrison, Andrew, Machin, Matthew, Maxwell, Anthony J, McWilliams, Lorna, Payne, Katherine, Qureshi, Nadeem, Ruane, Helen, Sampson, Sarah, Stavrinos, Paula, Thorpe, Emma, Ulph, Fiona, van Staa, Tjeerd, Woof, Victoria, Evans, D Gareth

“…In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce a better balance of benefits and harms. The…”
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Mammographic density change in a cohort of premenopausal women receiving tamoxifen for breast cancer prevention over 5 years by Brentnall, Adam R, Warren, Ruth, Harkness, Elaine F, Astley, Susan M, Wiseman, Julia, Fox, Jill, Fox, Lynne, Eriksson, Mikael, Hall, Per, Cuzick, Jack, Evans, D Gareth, Howell, Anthony

“…A decrease in breast density due to tamoxifen preventive therapy might indicate greater benefit from the drug. It is not known whether mammographic density…”
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Disease course of neurofibromatosis type 2: a 30-year follow-up study of 353 patients seen at a single institution by Forde, Claire, King, Andrew T, Rutherford, Scott A, Hammerbeck-Ward, Charlotte, Lloyd, Simon K, Freeman, Simon R, Pathmanaban, Omar N, Stapleton, Emma, Thomas, Owen M, Laitt, Roger D, Stivaros, Stavros, Kilday, John-Paul, Vassallo, Grace, McBain, Catherine, Kerrigan, Simon, Smith, Miriam J, McCabe, Martin G, Harkness, Elaine F, Evans, D Gareth

“…Abstract Background Limited data exist on the disease course of neurofibromatosis type 2 (NF2) to guide clinical trial design. Methods A prospective database…”
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Uptake of bilateral-risk-reducing-mastectomy: Prospective analysis of 7195 women at high-risk of breast cancer by Evans, D.Gareth, Gandhi, Ashu, Wisely, Julie, Clancy, Tara, Woodward, Emma R., Harvey, James, Highton, Lyndsey, Murphy, John, Barr, Lester, Howell, Sacha J., Lalloo, Fiona, Harkness, Elaine F., Howell, Anthony

“…Bilateral-Risk-Reducing-Mastectomy-(BRRM) is well described in BRCA1/2 pathogenic variant carriers. However, little is known about the relative uptake, time…”
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Magnitude and attributed reasons for adult weight gain amongst women at increased risk of breast cancer by Pegington, Mary, Harkness, Elaine F, Howell, Anthony, Evans, D Gareth, Harvie, Michelle

“…Excess weight (BMI ≥25.0 kg/m ) and weight gain during adult life increase the risk of postmenopausal breast cancer in women who are already at increased risk…”
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Exploring the prediction performance for breast cancer risk based on volumetric mammographic density at different thresholds by Wang, Chao, Brentnall, Adam R, Cuzick, Jack, Harkness, Elaine F, Evans, D Gareth, Astley, Susan

“…The percentage of mammographic dense tissue (PD) defined by pixel value threshold is a well-established risk factor for breast cancer. Recently there has been…”
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Validation of a new fully automated software for 2D digital mammographic breast density evaluation in predicting breast cancer risk by Giorgi Rossi, Paolo, Djuric, Olivera, Hélin, Valerie, Astley, Susan, Mantellini, Paola, Nitrosi, Andrea, Harkness, Elaine F., Gauthier, Emilien, Puliti, Donella, Balleyguier, Corinne, Baron, Camille, Gilbert, Fiona J., Grivegnée, André, Pattacini, Pierpaolo, Michiels, Stefan, Delaloge, Suzette

“…We compared accuracy for breast cancer (BC) risk stratification of a new fully automated system (DenSeeMammo—DSM) for breast density (BD) assessment to a…”
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Obesity at age 20 and weight gain during adulthood increase risk of total and premature all-cause mortality: findings from women attending breast screening in Manchester by Pegington, Mary, Harvie, Michelle, Harkness, Elaine F, Brentnall, Adam, Malcomson, Lee, Southworth, Jake, Fox, Jill, Howell, Anthony, Cuzick, Jack, Evans, D Gareth

“…Obesity in early adulthood is associated with lower breast cancer rates in later life. This could be interpreted as a positive reinforcement of excess weight…”
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Breast cancer risk in a screening cohort of Asian and white British/Irish women from Manchester UK by Evans, D Gareth, Brentnall, Adam R, Harvie, Michelle, Astley, Susan, Harkness, Elaine F, Stavrinos, Paula, Donnelly, Louise S, Sampson, Sarah, Idries, Faiza, Watterson, Donna, Cuzick, Jack, Wilson, Mary, Jain, Anil, Harrison, Fiona, Maxwell, Anthony J, Howell, Anthony

“…The differences between breast cancer risk factors in white British/Irish and Asian women attending screening in the UK are not well documented. Between…”
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Risk-based breast cancer screening strategies in women by Harkness, Elaine F., Astley, Susan M., Evans, D.Gareth

“…The incidence of breast cancer continues to increase worldwide. Population-based screening is available in many countries but may not be the most efficient use…”
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A case–control evaluation of 143 single nucleotide polymorphisms for breast cancer risk stratification with classical factors and mammographic density by Brentnall, Adam R., Veen, Elke M., Harkness, Elaine F., Rafiq, Sajjad, Byers, Helen, Astley, Susan M., Sampson, Sarah, Howell, Anthony, Newman, William G., Cuzick, Jack, Evans, Dafydd Gareth R.

“…Panels of single nucleotide polymorphisms (SNPs) stratify risk for breast cancer in women from the general population, but studies are needed assess their use…”
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The importance of ethnicity: Are breast cancer polygenic risk scores ready for women who are not of White European origin? by Evans, D. Gareth, Veen, Elke M., Byers, Helen, Roberts, Eleanor, Howell, Anthony, Howell, Sacha J., Harkness, Elaine F., Brentnall, Adam, Cuzick, Jack, Newman, William G.

“…Polygenic risk scores (PRS) for disease risk stratification show great promise for application in general populations, but most are based on data from…”
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Pathology update to the Manchester Scoring System based on testing in over 4000 families by Evans, D Gareth, Harkness, Elaine F, Plaskocinska, Inga, Wallace, Andrew J, Clancy, Tara, Woodward, Emma R, Howell, Tony A, Tischkowitz, Marc, Lalloo, Fiona

“…While the requirement for thresholds for testing for mutations in is being questioned, they are likely to remain for individuals unaffected by a relevant…”
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Breast cancer pathology and stage are better predicted by risk stratification models that include mammographic density and common genetic variants by Evans, D. Gareth R., Harkness, Elaine F., Brentnall, Adam R., van Veen, Elke M., Astley, Susan M., Byers, Helen, Sampson, Sarah, Southworth, Jake, Stavrinos, Paula, Howell, Sacha J., Maxwell, Anthony J., Howell, Anthony, Newman, William G., Cuzick, Jack

“…Purpose To improve breast cancer risk stratification to enable more targeted early detection/prevention strategies that will better balance risks and benefits…”
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Lynch syndrome caused by MLH1 mutations is associated with an increased risk of breast cancer: a cohort study by Harkness, Elaine F, Barrow, Emma, Newton, Katy, Green, Kate, Clancy, Tara, Lalloo, Fiona, Hill, James, Evans, D Gareth

“…Lynch syndrome is known to cause an increased risk of malignancies, including bowel and endometrial cancers. However, the risk of breast cancer associated with…”
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