Search Results - "Harkin, D. P."

The role of BRCA1 in transcriptional regulation and cell cycle control by Mullan, P B, Quinn, J E, Harkin, D P

“…The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell…”
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Cortactin underpins CD44-promoted invasion and adhesion of breast cancer cells to bone marrow endothelial cells by HILL, A, MCFARLANE, S, WAUGH, D. J. J, MULLIGAN, K, GILLESPIE, H, DRAFFIN, J. E, TRIMBLE, A, OUHTIT, A, JOHNSTON, P. G, HARKIN, D. P, MCCORMICK, D

“…Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the…”
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The Role of BRCA1 in the Cellular Response to Chemotherapy by Kennedy, Richard D., Quinn, Jennifer E., Mullan, Paul B., Johnston, Patrick G., Harkin, D. Paul

“…Germline mutations of the BRCA1 gene account for approximately 5% of breast and ovarian cancer cases, and lower than normal BRCA1 expression or function may be…”
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T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells by Redmond, K L, Crawford, N T, Farmer, H, D'Costa, Z C, O'Brien, G J, Buckley, N E, Kennedy, R D, Johnston, P G, Harkin, D P, Mullan, P B

“…T-box 2 (TBX2) is a transcription factor involved in mammary development and is known to be overexpressed in a subset of aggressive breast cancers. TBX2 has…”
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Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy by Jain, S., Lyons, C.A., Walker, S.M., McQuaid, S., Hynes, S.O., Mitchell, D.M., Pang, B., Logan, G.E., McCavigan, A.M., O’Rourke, D., McArt, D.G., McDade, S.S., Mills, I.G., Prise, K.M., Knight, L.A., Steele, C.J., Medlow, P.W., Berge, V., Katz, B., Loblaw, D.A., Harkin, D.P., James, J.A., O'sullivan, J.M., Kennedy, R.D., Waugh, D.J.

“…Radiotherapy is an effective treatment of intermediate/high-risk locally advanced prostate cancer, however, >30% of patients relapse within 5 years…”
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Heterozygous ATM mutations do not contribute to early onset of breast cancer by FitzGerald, Michael G, Bean, James M, Hegde, Sanjay R, Unsal, Hilal, MacDonald, Deborah J, Harkin, D. Paul, Finkelstein, Dianne M, Isselbacher, Kurt J, Haber, Daniel A

“…Ataxia telangiectasia (AT) is a recessive syndrome, including cerebellar degeneration, immunologic defects and cancer predisposition, attributed to mutations…”
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BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers by Tkocz, D, Crawford, N T, Buckley, N E, Berry, F B, Kennedy, R D, Gorski, J J, Harkin, D P, Mullan, P B

“…In this study we describe a novel interaction between the breast/ovarian tumor suppressor gene BRCA1 and the transcription factor GATA3, an interaction, which…”
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Increased expression of the RIα subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer by MCDAID, H. M, CAIRNS, M. T, ATKINSON, R. J, MCALEER, S, HARKIN, D. P, GILMORE, P, JOHNSTON, P. G

“…The primary element in the cAMP signal transduction pathway is the cAMP-dependent protein kinase (PKA). Expression of the RIα subunit of type I PKA is elevated…”
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NF-κB is a critical mediator of BRCA1-induced chemoresistance by Harte, M T, Gorski, J J, Savage, K I, Purcell, J W, Barros, E M, Burn, P M, McFarlane, C, Mullan, P B, Kennedy, R D, Perkins, N D, Harkin, D P

“…BRCA1 mediates resistance to apoptosis in response to DNA-damaging agents, causing BRCA1 wild-type tumours to be significantly more resistant to DNA damage…”
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5-Fluorouracil: mechanisms of action and clinical strategies by Johnston, Patrick G, Longley, Daniel B, Harkin, D. Paul

“…5-fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to…”
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Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors by Russell, S E, McIlhatton, M A, Burrows, J F, Donaghy, P G, Chanduloy, S, Petty, E M, Kalikin, L M, Church, S W, McIlroy, S, Harkin, D P, Keilty, G W, Cranston, A N, Weissenbach, J, Hickey, I, Johnston, P G

“…Allele losses from chromosome 17 are common in sporadic ovarian tumors. Previously, we reported high rates of LOH (up to 70%) from 17q25 at the marker THH59 in…”
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Prevalence of Germ-Line Mutations in p16, p19ARF, and CDK4 in Familial Melanoma: Analysis of a Clinic-Based Population by FitzGerald, Michael G., Harkin, D. Paul, Silva-Arrieta, Sandra, MacDonald, Deborah J., Lucchina, Leslie C., Unsal, Hilal, O'Neill, Erin, Koh, Jim, Finkelstein, Dianne M., Isselbacher, Kurt J., Sober, Arthur J., Haber, Daniel A.

“…Five to ten percent of individuals with melanoma have another affected family member, suggesting familial predisposition. Germ-line mutations in the…”
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Characterization of a thymidylate synthase (TS)-inducible cell line : A model system for studying sensitivity to TS- and non-TS-targeted chemotherapies by LONGLEY, Daniel B, FERGUSON, Paul R, BOYER, John, LATIF, Tariq, LYNCH, Maria, MAXWELL, Pamela, HARKIN, D. Paul, JOHNSTON, Patrick G

“…Thymidylate synthase (TS) is responsible for the de novo synthesis of thymidylate, which is required for DNA synthesis and repair and which is an important…”
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Immune microenvironment modulation following neoadjuvant therapy for oesophageal adenocarcinoma: a translational analysis of the DEBIOC clinical trial by Scanlon, E., Lavery, A., Albraikat, M., Stevenson, L., Kennedy, C., Byrne, R., Walker, A., Mullan-Young, B., McManus, D.T., Virdee, P.S., Elhussein, L., Turbitt, J., Collinson, D., Miedzybrodzka, Z., Van Schaeybroeck, S., McQuaid, S., James, J.A., Craig, S.G., Blayney, J.K., Petty, R.D., Harkin, D.P., Kennedy, R.D., Eatock, M.M., Middleton, M.R., Thomas, A., Turkington, R.C.

“…The Dual Erb B Inhibition in Oesophago-gastric Cancer (DEBIOC) trial reported an acceptable safety profile for neoadjuvant oxaliplatin and capecitabine (Xelox)…”
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Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70 by Maheswaran, S, Englert, C, Zheng, G, Lee, S B, Wong, J, Harkin, D P, Bean, J, Ezzell, R, Garvin, A J, McCluskey, R T, DeCaprio, J A, Haber, D A

“…The Wilms tumor suppressor WT1 encodes a zinc finger transcription factor that is expressed in glomerular podocytes during a narrow window in kidney…”
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Transforming Growth Factor-beta superfamily: evaluation as breast cancer biomarkers and preventive agents by Gupta, V, Harkin, D P, Kawakubo, H, Maheswaran, S

“…The Transforming Growth Factor-beta (TGFbeta) superfamily of cytokines is comprised of a number of structurally-related, secreted polypeptides that regulate a…”
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Role played by BRCA1 in regulating the cellular response to stress by Gilmore, P M, Quinn, J E, Mullan, P B, Andrews, H N, McCabe, N, Carty, M, Kennedy, R D, Harkin, D P

“…BRCA1 (breast-cancer susceptibility gene 1) is a tumour suppressor gene that is mutated in the germline of women with a genetic predisposition to breast and…”
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Role played by BRCA1 in transcriptional regulation in response to therapy by Murray, M M, Mullan, P B, Harkin, D P

“…BRCA1 (breast-cancer susceptibility gene 1) is a tumour suppressor, implicated in the hereditary predisposition to breast and ovarian cancer. BRCA1 has been…”
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Uncovering BRCA1-regulated signalling pathways by microarray-based expression profiling by Mullan, P B, McWilliams, S, Quinn, J, Andrews, H, Gilmore, P, McCabe, N, McKenna, S, Harkin, D P

“…The introduction of microarray technology to the scientific and medical communities has dramatically changed the way in which we now address basic biomedical…”
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Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1 by Harkin, D.Paul, Bean, James M, Miklos, David, Song, Young-Han, Truong, Vivi B, Englert, Christoph, Christians, Fred C, Ellisen, Leif W, Maheswaran, Shyamala, Oliner, Jonathan D, Haber, Daniel A

“…The breast cancer susceptibility gene BRCA1 encodes a protein implicated in the cellular response to DNA damage, with postulated roles in homologous…”
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