Toxicity Profile of Lutein and Lutein Ester Isolated From Marigold Flowers (Tagetes erecta)

Toxicity Profile of Lutein and Lutein Ester Isolated From Marigold Flowers (Tagetes erecta)

Lutein is a carotenoid with antioxidant properties and is commonly present in many fruits, vegetables, and egg yolk. Lutein affords protection against the development of the two common eye diseases of aging: cataract and macular degeneration. As the dietary lutein concentration is much lower compare...

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Bibliographic Details
Published in:International journal of toxicology Vol. 27; no. 1; pp. 1 - 9
Main Authors: Harikumar, Kuzhuvelil Bhaskarannair, Nimita, Chittikappil Venugopal, Preethi, Korengath Chandran, Kuttan, Ramadasan, Shankaranarayana, Madapura Lingappiah, Deshpande, Jayant
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01-01-2008
Subjects:
Animals
Blood Cell Count
Body Weight - drug effects
Eating - drug effects
Esters - isolation & purification
Esters - toxicity
Female
Flowers - chemistry
Flowers - toxicity
Kidney Function Tests
Lethal Dose 50
Leukocyte Count
Lipids - blood
Liver Function Tests
Lutein - isolation & purification
Lutein - toxicity
Lymphocyte Count
Male
Organ Size
Rats
Rats, Wistar
Sex Characteristics
Tagetes - chemistry
Tagetes - toxicity
Tagetes erecta
Water-Electrolyte Balance - drug effects
Lutein
Carotenoids
Macular pigment
Safety
Tagetes erecta
Toxicity
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Summary:Lutein is a carotenoid with antioxidant properties and is commonly present in many fruits, vegetables, and egg yolk. Lutein affords protection against the development of the two common eye diseases of aging: cataract and macular degeneration. As the dietary lutein concentration is much lower compared to the actual requirement to reduce macular degeneration, supplementation of lutein is under consideration. There are very few data on the toxicity of lutein. In the present study, the authors have evaluated the short-term and long-term toxicity profile of lutein and its esterified form isolated from marigold flowers (Tagetes erecta) in young adult male and female Wistar rats. Lutein and its ester form administered orally at doses of 4, 40, and 400 mg/kg body weight for 4 weeks for short-term toxicity study and 13 weeks for a subchronic toxicity study did not produced any mortality, change in body weight, food consumption pattern, organ weight, and other adverse side reactions. Administration of lutein and ester form did not alter the hepatic and renal function, and did not produce any change in the hematological parameters and in lipid profile. Histopathological analysis of the organs supported the nontoxicity of lutein and its ester form.
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ISSN:1091-5818
1092-874X
DOI:10.1080/10915810701876265