Design and Evaluation of Sustained Release of Ornidazole by Dental Inserts

Aim & Background: Ornidazole is an antimicrobial drug used to treat certain types of vaginal, urinary tract, and interstitial infections. The study aims to formulate and evaluate the dental inserts by using a drug candidate to sustained drug release to improve patient compliance, reduce dosing f...

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Bibliographic Details
Published in:	Current drug metabolism Vol. 22; no. 7; p. 572
Main Authors:	Harika, Sunchu, Kumar, Y Shravan, Rao, Y Madhusudhan, Sriram, Pavani, Shankar, Uma
Format:	Journal Article
Language:	English
Published:	Netherlands 01-01-2021
Subjects:	Anti-Infective Agents - administration & dosage Anti-Infective Agents - adverse effects Anti-Infective Agents - pharmacokinetics Anti-Infective Agents - therapeutic use Biological Availability Cellulose - analogs & derivatives Delayed-Action Preparations Dental Implants Drug Compounding Humans Hypromellose Derivatives Ornidazole - administration & dosage Ornidazole - adverse effects Ornidazole - pharmacokinetics Ornidazole - therapeutic use ethylcellulose pocket depth Intra pocket drug delivery anaerobic bacteria enhanced bioavailability sustained-release periodontal disease minimum inhibitory concentration
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Summary:	Aim & Background: Ornidazole is an antimicrobial drug used to treat certain types of vaginal, urinary tract, and interstitial infections. The study aims to formulate and evaluate the dental inserts by using a drug candidate to sustained drug release to improve patient compliance, reduce dosing frequency, reduce the risk of dose dumping, and avoid the first-pass metabolism. They have better therapeutic efficacy and fewer side effects. The dental inserts were prepared using various polymers alone and in combination with the different ratios of polymers. The evaluation parameters like thickness, drug content, content uniformity, moisture reuptake, weight variation, swelling studies, and erosion studies of the optimized inserts were studied. The in-vivo studies were conducted to determine the reduction of pocket depth in human volunteers. The system containing ethylcellulose and hydroxyl methyl propyl cellulose K100M (4:1) formulation F6 was optimized because drug release was sustained up to 120 hrs concerning other formulations. Optimized formulation followed first-order kinetics and Peppas release kinetics via fickian diffusion. There was no swelling, itching, irritation, and no reduction in the pocket depth in in-vivo studies. The study concluded that dental inserts could extend the release of Ornidazole for many hours and also enhance bioavailability. Furthermore, they also help in avoiding the first-pass effect. In vivo studies' observations showed no itching, irritation, swelling, and pocket-depth reduction.
ISSN:	1875-5453
DOI:	10.2174/1389200222666210222152940