Search Results - "Hariharan, Vignesh"

Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1 by Davis, Sarah M., Hariharan, Vignesh N., Lo, Agnes, Turanov, Anton A., Echeverria, Dimas, Sousa, Jacquelyn, McHugh, Nicholas, Biscans, Annabelle, Alterman, Julia F., Karumanchi, S. Ananth, Moore, Melissa J., Khvorova, Anastasia

“…Preeclampsia (PE) is a rising, potentially lethal complication of pregnancy. PE is driven primarily by the overexpression of placental soluble fms-like…”
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Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA by Hariharan, Vignesh N., Nakamura, Takahiro, Shin, Minwook, Tang, Qi, Sontakke, Vyankat, Caiazzi, Jillian, Hildebrand, Samuel, Khvorova, Anastasia, Yamada, Ken

“…Small interfering RNAs (siRNAs) are revolutionizing the treatment of liver-associated indications. Yet, robust delivery to extrahepatic tissues remains a…”
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Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection by Hariharan, Vignesh N, Shin, Minwook, Chang, Ching-Wen, O'Reilly, Daniel, Biscans, Annabelle, Yamada, Ken, Guo, Zhiru, Somasundaran, Mohan, Tang, Qi, Monopoli, Kathryn, Krishnamurthy, Pranathi Meda, Devi, Gitali, McHugh, Nicholas, Cooper, David A, Echeverria, Dimas, Cruz, John, Chan, Io Long, Liu, Ping, Lim, Sun-Young, McConnell, Jill, Singh, Satya Prakash, Hildebrand, Samuel, Sousa, Jacquelyn, Davis, Sarah M, Kennedy, Zachary, Ferguson, Chantal, Godinho, Bruno M D C, Thillier, Yann, Caiazzi, Jillian, Ly, Socheata, Muhuri, Manish, Kelly, Karen, Humphries, Fiachra, Cousineau, Alyssa, Parsi, Krishna Mohan, Li, Qi, Wang, Yang, Maehr, René, Gao, Guangping, Korkin, Dmitry, McDougall, William M, Finberg, Robert W, Fitzgerald, Katherine A, Wang, Jennifer P, Watts, Jonathan K, Khvorova, Anastasia

“…The continuous evolution of SARS-CoV-2 variants complicates efforts to combat the ongoing pandemic, underscoring the need for a dynamic platform for the rapid…”
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Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin by Tang, Qi, Fakih, Hassan H., Zain UI Abideen, Mohammad, Hildebrand, Samuel R., Afshari, Khashayar, Gross, Katherine Y., Sousa, Jacquelyn, Maebius, Allison S., Bartholdy, Christina, Søgaard, Pia Pernille, Jackerott, Malene, Hariharan, Vignesh, Summers, Ashley, Fan, Xueli, Okamura, Ken, Monopoli, Kathryn R., Cooper, David A., Echeverria, Dimas, Bramato, Brianna, McHugh, Nicholas, Furgal, Raymond C., Dresser, Karen, Winter, Sarah J., Biscans, Annabelle, Chuprin, Jane, Haddadi, Nazgol-Sadat, Sherman, Shany, Yıldız-Altay, Ümmügülsüm, Rashighi, Mehdi, Richmond, Jillian M., Bouix-Peter, Claire, Blanchard, Carine, Clauss, Adam, Alterman, Julia F., Khvorova, Anastasia, Harris, John E.

“…Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK…”
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Enhancing siRNA efficacy in vivo with extended nucleic acid backbones by Yamada, Ken, Hariharan, Vignesh N, Caiazzi, Jillian, Miller, Rachael, Ferguson, Chantal M, Sapp, Ellen, Fakih, Hassan H, Tang, Qi, Yamada, Nozomi, Furgal, Raymond C, Paquette, Joseph D, Biscans, Annabelle, Bramato, Brianna M, McHugh, Nicholas, Summers, Ashley, Lochmann, Clemens, Godinho, Bruno M D C, Hildebrand, Samuel, Jackson, Samuel O, Echeverria, Dimas, Hassler, Matthew R, Alterman, Julia F, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

“…Therapeutic small interfering RNA (siRNA) requires sugar and backbone modifications to inhibit nuclease degradation. However, metabolic stabilization by…”
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Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity by Fakih, Hassan H, Tang, Qi, Summers, Ashley, Shin, Minwook, Buchwald, Julianna E, Gagnon, Rosemary, Hariharan, Vignesh N, Echeverria, Dimas, Cooper, David A, Watts, Jonathan K, Khvorova, Anastasia, Sleiman, Hanadi F

“…Although an increasing number of small interfering RNA (siRNA) therapies are reaching the market, the challenge of efficient extra-hepatic delivery continues…”
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Antiplatelet Treatment Patterns and Outcomes for Secondary Stroke Prevention in the United Kingdom by Liu, Xuejun, Jiang, Jenny, Li, Danshi, Horrow, Jay, Tamada, Hiroshi, Kahl, Anja, Hariharan, Vignesh, Avinav, Ankur, Li, Xiaoyan

“…Introduction Stroke is a leading cause of death and disability worldwide. Antiplatelet therapies are recommended to reduce the risk of recurrent stroke in…”
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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles by Biscans, Annabelle, Caiazzi, Jillian, McHugh, Nicholas, Hariharan, Vignesh, Muhuri, Manish, Khvorova, Anastasia

“…Oligonucleotide therapeutics hold promise for the treatment of muscle- and heart-related diseases. However, oligonucleotide delivery across the continuous…”
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Cyclic di‐GMP sensing histidine kinase PdtaS controls mycobacterial adaptation to carbon sources by Hariharan, Vignesh Narayan, Yadav, Rahul, Thakur, Chandrani, Singh, Albel, Gopinathan, Renu, Singh, Devendra Pratap, Sankhe, Gaurav, Malhotra, Vandana, Chandra, Nagasuma, Bhatt, Apoorva, Saini, Deepak Kumar

“…Cell signaling relies on second messengers to transduce signals from the sensory apparatus to downstream signaling pathway components. In bacteria, one of the…”
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Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease by O'Reilly, Daniel, Belgrad, Jillian, Ferguson, Chantal, Summers, Ashley, Sapp, Ellen, McHugh, Cassandra, Mathews, Ella, Boudi, Adel, Buchwald, Julianna, Ly, Socheata, Moreno, Dimas, Furgal, Raymond, Luu, Eric, Kennedy, Zachary, Hariharan, Vignesh, Monopoli, Kathryn, Yang, X. William, Carroll, Jeffery, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

“…Huntington’s disease (HD) is a severe neurodegenerative disorder caused by the expansion of the CAG trinucleotide repeat tract in the huntingtin gene…”
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Abstract WP7: Utilization and Outcomes Associated With DAPT and ASA Monotherapy Amongst Hospitalizations With Large Vessel Occlusion: A Nationwide Cross-Sectional Analysis by Patel, Hemal, Patel, Urvish K, Shah, Dhaivat, Khan, Sumaiya, Priya Peram, Raga, Nandigam, Mani Deep, Matteda, Tanmayi, Jayan, Gopika, Gowdru, Kiran, Kelangi, Sarah Susan, Munnangi, Jyothsna, Hariharan, Vignesh Krishna, Khotele, Chinmay, Sabapathy, Pradeep Kumar, Arora, Rohan

“…Abstract only Background: In clinical trials like SPS3, MATCH, CHANCE, and POINT, dual antiplatelet treatment (DAPT) has been compared to aspirin (ASA) alone…”
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Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy by Engelbeen, Sarah, O'Reilly, Daniel, Van De Vijver, Davy, Verhaart, Ingrid, van Putten, Maaike, Hariharan, Vignesh, Hassler, Matthew, Khvorova, Anastasia, Damha, Masad J, Aartsma-Rus, Annemieke

“…Antisense oligonucleotide (AON)-mediated exon skipping is a promising therapeutic approach for Duchenne muscular dystrophy (DMD) patients to restore dystrophin…”
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Phosphocholine Headgroup Chemistry Alters the Extrahepatic Accumulation of Lipid Conjugated siRNA by Hariharan, Vignesh N., Nakamura, Takahiro, Shin, Minwook, Tang, Qi, Sontakke, Vyankat, Caiazzi, Jillian, Hildebrand, Samuel, Khvorova, Anastasia, Yamada, Ken

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A combinatorial approach for achieving CNS-selective RNAi by Ferguson, Chantal M, Godinho, Bruno M D C, Echeverria, Dimas, Hassler, Matthew, Vangjeli, Lorenc, Sousa, Jacquelyn, McHugh, Nicholas, Alterman, Julia, Hariharan, Vignesh, Krishnamurthy, Pranathi Meda, Watts, Jonathan, Rogaev, Eveny, Khvorova, Anastasia

“…RNA interference (RNAi) is an endogenous process that can be harnessed using chemically modified small interfering RNAs (siRNAs) to potently modulate gene…”
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Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease by O’Reilly, Daniel, Belgrad, Jillian, Ferguson, Chantal, Summers, Ashley, Sapp, Ellen, McHugh, Cassandra, Mathews, Ella, Boudi, Adel, Buchwald, Julianna, Ly, Socheata, Moreno, Dimas, Furgal, Raymond, Luu, Eric, Kennedy, Zachary, Hariharan, Vignesh, Monopoli, Kathryn, Yang, X. William, Carroll, Jeffery, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

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A serpentine way to signaling: Nobel Prize in Chemistry, 2012 by Hariharan, Vignesh Narayan, Nair, Raji R., Saini, Deepak Kumar

“…The Nobel Prize in Chemistry, 2012 has been awarded to Robert J Lefkowitz and Brian K Kobilka for their studies on G-Protein Coupled Receptors (GPCRs). GPCRs…”
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A Review on NFC for Secure Transaction its Fundamental Challenges and Future Directions by Gupta, Kartik, Bhanodia, Praveen, Sethi, Kamal Kumar, Rajput, Shivshankar, Patidar, Mukesh, Iyer, Vignesh Hariharan

“…Near-Field Communication (NFC) payment solutions are contactless payment solutions which harness the short-range communication capabilities and existing RFID…”
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