Search Results - "Haridas, P A Nidhina"

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin by Nidhina Haridas, P. A, Soronen, Jarkko, Sädevirta, Sanja, Mysore, Raghavendra, Quagliarini, Fabiana, Pasternack, Arja, Metso, Jari, Perttilä, Julia, Leivonen, Marja, Smas, Cynthia M, Fischer-Posovszky, Pamela, Wabitsch, Martin, Ehnholm, Christian, Ritvos, Olli, Jauhiainen, Matti, Olkkonen, Vesa M, Yki-Järvinen, Hannele

“…Objective: Circulating ANGPTL8 has recently been used as a marker of insulin action. We studied expression and insulin regulation of ANGPTL8 and ANGPTL3 in…”
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Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD by Luukkonen, Panu K, Zhou, You, Nidhina Haridas, P.A, Dwivedi, Om P, Hyötyläinen, Tuulia, Ali, Ashfaq, Juuti, Anne, Leivonen, Marja, Tukiainen, Taru, Ahonen, Linda, Scott, Emma, Palmer, Jeremy M, Arola, Johanna, Orho-Melander, Marju, Vikman, Petter, Anstee, Quentin M, Olkkonen, Vesa M, Orešič, Matej, Groop, Leif, Yki-Järvinen, Hannele

“…Graphical abstract…”
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MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes by Mysore, Raghavendra, Ortega, Francisco J, Latorre, Jèssica, Ahonen, Maria, Savolainen-Peltonen, Hanna, Fischer-Posovszky, Pamela, Wabitsch, Martin, Olkkonen, Vesa M, Fernández-Real, José M, Haridas, P A Nidhina

“…Abstract Context Angiopoietin-like 8 (ANGPTL8) has been identified as a key regulator of lipid metabolism. Design We addressed the correlation between ANGPTL8…”
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Adipocyte-endothelial cell interplay in adipose tissue physiology by Chaurasiya, Vaishali, Nidhina Haridas, P.A., Olkkonen, Vesa M.

“…[Display omitted] Adipose tissue (AT) expansion through hyperplasia or hypertrophy requires vascular remodeling that involves angiogenesis. There is quite some…”
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Depletion of TM6SF2 disturbs membrane lipid composition and dynamics in HuH7 hepatoma cells by Ruhanen, Hanna, Nidhina Haridas, P.A., Eskelinen, Eeva-Liisa, Eriksson, Ove, Olkkonen, Vesa M., Käkelä, Reijo

“…A polymorphism of TM6SF2 associates with hepatic lipid accumulation and reduction of triacylglycerol (TAG) secretion, but the function of the encoded protein…”
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Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition by Mysore, Raghavendra, Liebisch, Gerhard, Zhou, You, Olkkonen, Vesa M., Nidhina Haridas, P.A.

“…•ANGPTL8 regulates adipocyte intracellular lipolysis.•ANGPTL8 is involved in maintaining adipocyte phospholipid composition.•ANGPTL8 regulates the expression…”
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Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease by Luukkonen, Panu K, Tukiainen, Taru, Juuti, Anne, Sammalkorpi, Henna, Haridas, P A Nidhina, Niemelä, Onni, Arola, Johanna, Orho-Melander, Marju, Hakkarainen, Antti, Kovanen, Petri T, Dwivedi, Om, Groop, Leif, Hodson, Leanne, Gastaldelli, Amalia, Hyötyläinen, Tuulia, Orešič, Matej, Yki-Järvinen, Hannele

“…Carriers of the hydroxysteroid 17-β dehydrogenase 13 (HSD17B13) gene variant (rs72613567:TA) have a reduced risk of NASH and cirrhosis but not steatosis. We…”
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Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes by Ahonen, Maria A., Höring, Marcus, Nguyen, Van Dien, Qadri, Sami, Taskinen, Juuso H., Nagaraj, Meghana, Wabitsch, Martin, Fischer-Posovszky, Pamela, Zhou, You, Liebisch, Gerhard, Haridas, P. A. Nidhina, Yki-Järvinen, Hannele, Olkkonen, Vesa M.

“…Abstract Background Thyroid hormone responsive protein (THRSP) is a lipogenic nuclear protein that is highly expressed in murine adipose tissue, but its role…”
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Short-Term Cooling Increases Plasma ANGPTL3 and ANGPTL8 in Young Healthy Lean Men but Not in Middle-Aged Men with Overweight and Prediabetes by Janssen, Laura G M, Jauhiainen, Matti, Olkkonen, Vesa M, Haridas, P A Nidhina, Nahon, Kimberly J, Rensen, Patrick C N, Boon, Mariëtte R

“…Angiopoietin-like proteins (ANGPTLs) regulate triglyceride (TG)-rich lipoprotein distribution via inhibiting TG hydrolysis by lipoprotein lipase in metabolic…”
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Angiopoietin-like protein 3, an emerging cardiometabolic therapy target with systemic and cell-autonomous functions by Ruhanen, Hanna, Haridas, P.A. Nidhina, Jauhiainen, Matti, Olkkonen, Vesa M.

“…Angiopoietin like protein 3 (ANGPTL3) is best known for its function as an inhibitor of lipoprotein and endothelial lipases. Due to the capacity of genetic or…”
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miR-107 inhibits CDK6 expression, differentiation, and lipid storage in human adipocytes by Ahonen, Maria A., Haridas, P.A. Nidhina, Mysore, Raghavendra, Wabitsch, Martin, Fischer-Posovszky, Pamela, Olkkonen, Vesa M.

“…MicroRNA-107 (miR-107) plays a regulatory role in obesity and insulin resistance, but the mechanisms of its function in adipocytes have not been elucidated in…”
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Human visceral adipose tissue microvascular endothelial cell isolation and establishment of co-culture with white adipocytes to analyze cell-cell communication by Chaurasiya, Vaishali, Pham, Dan Duc, Harju, Jukka, Juuti, Anne, Penttilä, Anne, Emmagouni, Sharath Kumar Goud, Nguyen, Van Dien, Zhang, Birong, Perttunen, Sanni, Keskitalo, Salla, Zhou, You, Pietiläinen, Kirsi H, Haridas, P A Nidhina, Olkkonen, Vesa M

“…Communication between adipocytes and endothelial cells (EC) is suggested to play an important role in the metabolic function of white adipose tissue. In order…”
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GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth by Nagaraj, Meghana, Höring, Marcus, Ahonen, Maria A., Nguyen, Van Dien, Zhou, You, Vihinen, Helena, Jokitalo, Eija, Liebisch, Gerhard, Nidhina Haridas, P.A., Olkkonen, Vesa M.

“…Golgi membrane protein 1 (GOLM1) is a Golgi-resident type 2 transmembrane protein known to be overexpressed in several cancers, including hepatocellular…”
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Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p by Ahonen, Maria A., Asghar, Muhammad Yasir, Parviainen, Suvi J., Liebisch, Gerhard, Höring, Marcus, Leidenius, Marjut, Fischer-Posovszky, Pamela, Wabitsch, Martin, Mikkola, Tomi S., Törnquist, Kid, Savolainen-Peltonen, Hanna, Haridas, P.A. Nidhina, Olkkonen, Vesa M.

“…MicroRNA-221-3p (miR-221-3p) is associated with both metabolic diseases and cancers. However, its role in terminal adipocyte differentiation and lipid…”
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ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins by Ruhanen, Hanna, Haridas, P.A. Nidhina, Minicocci, Ilenia, Taskinen, Juuso H., Palmas, Francesco, di Costanzo, Alessia, D'Erasmo, Laura, Metso, Jari, Partanen, Jennimari, Dalli, Jesmond, Zhou, You, Arca, Marcello, Jauhiainen, Matti, Käkelä, Reijo, Olkkonen, Vesa M.

“…Loss-of-function (LOF) mutations in ANGPTL3, an inhibitor of lipoprotein lipase (LPL), cause a drastic reduction of serum lipoproteins and protect against the…”
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MicroRNA-192 impairs adipocyte triglyceride storage by Mysore, Raghavendra, Zhou, You, Sädevirta, Sanja, Savolainen-Peltonen, Hanna, Nidhina Haridas, P.A., Soronen, Jarkko, Leivonen, Marja, Sarin, Antti-Pekka, Fischer-Posovszky, Pamela, Wabitsch, Martin, Yki-Järvinen, Hannele, Olkkonen, Vesa M.

“…We investigated the expression of miR-192* (miR-192-3p) in the visceral adipose tissue (VAT) of obese subjects and its function in cultured human adipocytes…”
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Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes by Latorre, Jèssica, Ortega, Francisco J., Liñares-Pose, Laura, Moreno-Navarrete, José M., Lluch, Aina, Comas, Ferran, Oliveras-Cañellas, Núria, Ricart, Wifredo, Höring, Marcus, Zhou, You, Liebisch, Gerhard, Nidhina Haridas, P.A., Olkkonen, Vesa M., López, Miguel, Fernández-Real, José M.

“…While the impact of metformin in hepatocytes leads to fatty acid (FA) oxidation and decreased lipogenesis, hepatic microRNAs (miRNAs) have been associated with…”
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Ellagic acid stimulates glucose transport in 3T3‐L1 adipocytes and C2C12 myotubes by AMP activated protein kinase mediated pathway by Poulose, Ninu, Prasad, Vishnu, Nidhina Haridas, P. A, Gopalakrishnapillai, Anilkumar

“…Glucose Transporter 4 (GLUT4) is an insulin sensitive glucose transporter isoform predominantly expressed in adipocytes and skeletal muscle. It is largely…”
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