Search Results - "Hargreaves, Victoria V"

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch by Liu, Nan, Hargreaves, Victoria V., Zhu, Qian, Kurland, Jesse V., Hong, Jiyoung, Kim, Woojin, Sher, Falak, Macias-Trevino, Claudio, Rogers, Julia M., Kurita, Ryo, Nakamura, Yukio, Yuan, Guo-Cheng, Bauer, Daniel E., Xu, Jian, Bulyk, Martha L., Orkin, Stuart H.

“…Fetal hemoglobin (HbF, α2γ2) level is genetically controlled and modifies severity of adult hemoglobin (HbA, α2β2) disorders, sickle cell disease, and…”
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conserved MutS homolog connector domain interface interacts with MutL homologs by Mendillo, Marc L, Hargreaves, Victoria V, Jamison, Jonathan W, Mo, Ashley O, Li, Sheng, Putnam, Christopher D, Woods, Virgil L. Jr, Kolodner, Richard D

“…Escherichia coli MutS forms a mispair-dependent ternary complex with MutL that is essential for initiating mismatch repair (MMR) but is structurally…”
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Interaction between the Msh2 and Msh6 Nucleotide-binding Sites in the Saccharomyces cerevisiae Msh2-Msh6 Complex by Hargreaves, Victoria V., Shell, Scarlet S., Mazur, Dan J., Hess, Martin T., Kolodner, Richard D.

“…Indirect evidence has suggested that the Msh2-Msh6 mispair-binding complex undergoes conformational changes upon binding of ATP and mispairs, resulting in the…”
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Engineered Disulfide-forming Amino Acid Substitutions Interfere with a Conformational Change in the Mismatch Recognition Complex Msh2-Msh6 Required for Mismatch Repair by Hargreaves, Victoria V., Putnam, Christopher D., Kolodner, Richard D.

“…ATP binding causes the mispair-bound Msh2-Msh6 mismatch recognition complex to slide along the DNA away from the mismatch, and ATP is required for the…”
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Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding by Dragan, Anatoly I, Hargreaves, Victoria V, Makeyeva, Elena N, Privalov, Peter L

“…The interferon regulatory transcription factor (IRF-3) is activated by phosphorylation of Ser/Thr residues clustered in its C-terminal domain. Phosphorylation…”
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The Salt Dependence of the Interferon Regulatory Factor 1 DNA Binding Domain Binding to DNA Reveals Ions Are Localized around Protein and DNA by Hargreaves, Victoria V, Schleif, Robert F

“…The equilibrium dissociation constant of the DNA binding domain of interferon regulatory factor 1 (IRF1 DBD) for its DNA binding site depends strongly on salt…”
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Stability and DNA Binding Ability of the DNA Binding Domains of Interferon Regulatory Factors 1 and 3 by Hargreaves, Victoria V, Makeyeva, Elena N, Dragan, Anatoly I, Privalov, Peter L

“…The thermodynamic properties and DNA binding ability of the N-terminal DNA binding domains of interferon regulatory factors IRF-1 (DBD1) and IRF-3 (DBD3) were…”
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Fetal Hemoglobin (HbF) Silencer BCL11A Acts through a Novel DNA-Motif in the Gamma-Globin Promoters, Simplifying the Model for Hemoglobin Switching by Liu, Nan, Hargreaves, Victoria V, Hong, Jiyoung, Kim, Woojin, Kurland, Jesse, Zhu, Qian, Sher, Falak, Macias-Trevino, Claudio, Rogers, Jill, Yuan, Guo-Cheng, Bauer, Daniel E., Xu, Jian, Bulyk, Martha L, Orkin, Stuart

“…Fetal hemoglobin (HbF) level is under strong genetic control. Common genetic variation is associated with modest elevation in HbF levels in adults. Genome-wide…”
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Salt Dependence of IRF1 DBD Binding to DNA Reveals Ions Are Localized Around Protein and DNA by Hargreaves, Victoria V., Schleif, Robert F.

“…The equilibrium dissociation constant of the DNA binding domain of interferon regulatory factor 1, IRF1 DBD, for its DNA binding site depends strongly on salt…”
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