Search Results - "Hargreaves, K.M"

Scaffold-free Prevascularized Microtissue Spheroids for Pulp Regeneration by Dissanayaka, W.L., Zhu, L., Hargreaves, K.M., Jin, L., Zhang, C.

“…Creating an optimal microenvironment that mimics the extracellular matrix (ECM) of natural pulp and securing an adequate blood supply for the survival of cell…”
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LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons by Diogenes, A., Ferraz, C.C.R., Akopian, A.N., Henry, M.A., Hargreaves, K.M.

“…Recent studies have demonstrated that the lipopolysaccharide (LPS) receptor (TLR4) is expressed in TRPV1 containing trigeminal sensory neurons. In this study,…”
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Trigeminal Nociceptors Express TLR-4 and CD14: a Mechanism for Pain due to Infection by Wadachi, R., Hargreaves, K.M.

“…Although certain bacterial species appear to be risk factors for pain due to odontogenic infections, comparatively little is known about the potential…”
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NGF Up-regulates TRPA1: Implications for Orofacial Pain by Diogenes, A., Akopian, A.N., Hargreaves, K.M.

“…The transient receptor potential ankyrin repeat 1 (TRPA1) channel is believed to be involved in many forms of acute and chronic hyperalgesia. Nerve Growth…”
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Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat by Loyd, D.R, Chen, P.B, Hargreaves, K.M

“…Abstract The peripheral serotonergic system has been implicated in the modulation of an array of pain states, from migraine to fibromyalgia; however, the…”
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Tumor necrosis factor α enhances the sensitivity of rat trigeminal neurons to capsaicin by Khan, A.A, Diogenes, A, Jeske, N.A, Henry, M.A, Akopian, A, Hargreaves, K.M

“…Abstract Tumor necrosis factor α (TNFα), a pro-inflammatory cytokine, enhances the development of pain and hyperalgesia, although the molecular mechanisms are…”
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The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons by Price, T.J., Flores, C.M., Cervero, F., Hargreaves, K.M.

“…Neuronal proteins have been traditionally viewed as being derived solely from the soma; however, accumulating evidence indicates that dendritic and axonal…”
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The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat by Price, T.J, Helesic, G, Parghi, D, Hargreaves, K.M, Flores, C.M

“…Cannabinoid compounds have been shown to produce antinociception and antihyperalgesia by acting upon cannabinoid receptors located in both the CNS and the…”
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Integrins regulate opioid receptor signaling in trigeminal ganglion neurons by Berg, K.A, Zardeneta, G, Hargreaves, K.M, Clarke, W.P, Milam, S.B

“…Abstract The binding of integrins to the extracellular matrix results in focal organization of the cytoskeleton and the genesis of intracellular signals that…”
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Trigeminal Nociceptors Express Prostaglandin Receptors by Patwardhan, A.M., Vela, J., Farugia, J., Vela, K., Hargreaves, K.M.

“…Orofacial inflammation is associated with prostaglandin release and the sensitization of nociceptive receptors such as the transient receptor potential subtype…”
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Tissue pH and Temperature Regulate Pulpal Nociceptors by Goodis, H.E., Poon, A., Hargreaves, K.M.

“…The TRPV1 receptor acts as a sensor for environmental changes in pH and temperature. Since many nociceptors express TRPV1, it is possible that local…”
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The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in the uterine cervix, dorsal root ganglia and spinal cord by Mowa, C.N, Usip, S, Collins, J, Storey-Workley, M, Hargreaves, K.M, Papka, R.E

“…Before parturition the uterine cervix undergoes a ripening process (“softens” and dilates) to allow passage of the fetus at term. The exact mechanism(s)…”
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Activation of Excitatory Amino Acid Receptors in Bovine Dental Pulp Evokes the Release of iCGRP by Jackson, D.L., Hargreaves, K.M.

“…The activation of excitatory amino acid (EAA) receptors within the central nervous system is associated with numerous centrally mediated phenomena, including…”
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Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammation by Galeazza, M.T., Garry, M.G., Yost, H.J., Strait, K.A., Hargreaves, K.M., Seybold, V.S.

“…Several indices of peptidergic, primary afferent neural transmission in rat at the level of the lumbar spinal cord exhibited differential changes over time in…”
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Role of Oxidized Lipids and TRP Channels in Orofacial Pain and Inflammation by Hargreaves, K.M., Ruparel, S.

“…Acute or chronic inflammation comprises a highly prevalent type of orofacial pain and is mediated by the generation of endogenous agonists that activate…”
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A comparison of multiple injections versus continuous infusion of nicotine for producing up-regulation of neuronal [ 3H]-epibatidine binding sites by Ulrich, Y.M., Hargreaves, K.M., Flores, C.M.

“…Chronic nicotine exposure in the rat produces a characteristic increase in neuronal nicotinic binding sites in many brain regions. The conventional method for…”
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Association Between Recurrent Aphthous Stomatitis and Upper Gastrointestinal tract disease by Baccaglini, L, Shuster, J.J, Brantly, M.L, Hargreaves, K.M, Bhattacharyya, I, Lampe, A.D, Cha, S, Katz, J, Handfield, M, Wang, C, Theriaque, D.W

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Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016 by Herzog, C.R., Berzins, D.W., DenBesten, P., Gregory, R.L., Hargreaves, K.M., Messer, R.L.W., Mina, M., Mooney, M.P., Paine, M.L., Phillips, C., Presland, R.B., Quivey, R.G., Scannapieco, F.A., Sheridan, J.F., Svoboda, K.K.H., Trackman, P.C., Walker, M.P., Walker, S.G., Wang, C.Y., Hu, J.C.C.

“…For decades, dental schools in the United States have endured a significant faculty shortage. Studies have determined that the top 2 sources of dental faculty…”
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Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist by Costello, A H, Hargreaves, K M

“…Although bradykinin (BK) antagonists have antinociceptive effects, they have not been evaluated for anti-inflammatory activity. When administered with…”
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Neuropeptide Y Y1 Receptor Effects on Pulpal Nociceptors by Gibbs, J.L., Hargreaves, K.M.

“…Neuropeptide Y (NPY) is an important modulatory neuropeptide that regulates several physiological systems, including the activity of sensory neurons. We…”
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