Search Results - "Hargreaves, K M"

LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons by Diogenes, A., Ferraz, C.C.R., Akopian, A.N., Henry, M.A., Hargreaves, K.M.

“…Recent studies have demonstrated that the lipopolysaccharide (LPS) receptor (TLR4) is expressed in TRPV1 containing trigeminal sensory neurons. In this study,…”
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Trigeminal Nociceptors Express TLR-4 and CD14: a Mechanism for Pain due to Infection by Wadachi, R., Hargreaves, K.M.

“…Although certain bacterial species appear to be risk factors for pain due to odontogenic infections, comparatively little is known about the potential…”
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NGF Up-regulates TRPA1: Implications for Orofacial Pain by Diogenes, A., Akopian, A.N., Hargreaves, K.M.

“…The transient receptor potential ankyrin repeat 1 (TRPA1) channel is believed to be involved in many forms of acute and chronic hyperalgesia. Nerve Growth…”
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Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat by Loyd, D.R, Chen, P.B, Hargreaves, K.M

“…Abstract The peripheral serotonergic system has been implicated in the modulation of an array of pain states, from migraine to fibromyalgia; however, the…”
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The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat by Price, T.J, Helesic, G, Parghi, D, Hargreaves, K.M, Flores, C.M

“…Cannabinoid compounds have been shown to produce antinociception and antihyperalgesia by acting upon cannabinoid receptors located in both the CNS and the…”
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The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons by Price, T.J., Flores, C.M., Cervero, F., Hargreaves, K.M.

“…Neuronal proteins have been traditionally viewed as being derived solely from the soma; however, accumulating evidence indicates that dendritic and axonal…”
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Tissue pH and Temperature Regulate Pulpal Nociceptors by Goodis, H.E., Poon, A., Hargreaves, K.M.

“…The TRPV1 receptor acts as a sensor for environmental changes in pH and temperature. Since many nociceptors express TRPV1, it is possible that local…”
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Scaffold-free Prevascularized Microtissue Spheroids for Pulp Regeneration by Dissanayaka, W.L., Zhu, L., Hargreaves, K.M., Jin, L., Zhang, C.

“…Creating an optimal microenvironment that mimics the extracellular matrix (ECM) of natural pulp and securing an adequate blood supply for the survival of cell…”
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Role of Oxidized Lipids and TRP Channels in Orofacial Pain and Inflammation by Hargreaves, K.M., Ruparel, S.

“…Acute or chronic inflammation comprises a highly prevalent type of orofacial pain and is mediated by the generation of endogenous agonists that activate…”
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Integrins regulate opioid receptor signaling in trigeminal ganglion neurons by Berg, K.A, Zardeneta, G, Hargreaves, K.M, Clarke, W.P, Milam, S.B

“…Abstract The binding of integrins to the extracellular matrix results in focal organization of the cytoskeleton and the genesis of intracellular signals that…”
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Association of oral microbiome with type 2 diabetes risk by Long, J., Cai, Q., Steinwandel, M., Hargreaves, M. K., Bordenstein, S. R., Blot, W. J., Zheng, W., Shu, X. O.

“…Background and Objective The oral microbiome may help to maintain systemic health, including how it affects blood glucose levels; however, direct evidence…”
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Trigeminal Nociceptors Express Prostaglandin Receptors by Patwardhan, A.M., Vela, J., Farugia, J., Vela, K., Hargreaves, K.M.

“…Orofacial inflammation is associated with prostaglandin release and the sensitization of nociceptive receptors such as the transient receptor potential subtype…”
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Neuropeptide Y inhibits capsaicin-sensitive nociceptors via a Y1-receptor-mediated mechanism by Gibbs, J., Flores, C.M., Hargreaves, K.M.

“…Neuropeptide Y (NPY) is expressed in certain primary afferent fibers, is up-regulated in response to tissue injury and is capable of inhibiting nociceptive…”
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Antihyperalgesic effects of spinal cannabinoids by Richardson, Jennelle Durnett, Aanonsen, Lin, Hargreaves, Kenneth M

“…Cannabinoids have been widely reported to produce antinociception in models such as tail flick and hot plate. However, their role in modulating thermal…”
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Distinct ATP receptors on pain-sensing and stretch-sensing neurons by Cook, Sean P, Vulchanova, Lucy, Hargreaves, Kenneth M, Elde, Robert, McCleskey, Edwin W

“…The initial pain from tissue damage may result from the release of cytoplasmic components that act upon nociceptors, the sensors for pain. ATP was proposed to…”
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The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in the uterine cervix, dorsal root ganglia and spinal cord by Mowa, C.N, Usip, S, Collins, J, Storey-Workley, M, Hargreaves, K.M, Papka, R.E

“…Before parturition the uterine cervix undergoes a ripening process (“softens” and dilates) to allow passage of the fetus at term. The exact mechanism(s)…”
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Should we conduct a trial of distributing naloxone to heroin users for peer administration to prevent fatal overdose? by Lenton, Simon R, Hargreaves, Kim M

“…Heroin overdose is a major cause of death among heroin users, and often occurs in the company of other users. However, sudden death after injection is rare,…”
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SR 141716A, a cannabinoid receptor antagonist, produces hyperalgesia in untreated mice by Richardson, Jennelle Durnett, Aanonsen, Lin, Hargreaves, Kenneth M

“…Antinociceptive effects of cannabinoids are well documented. However, the physiological role of endogenous cannabinoids in nociception is unknown. We evaluated…”
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Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammation by Galeazza, M.T., Garry, M.G., Yost, H.J., Strait, K.A., Hargreaves, K.M., Seybold, V.S.

“…Several indices of peptidergic, primary afferent neural transmission in rat at the level of the lumbar spinal cord exhibited differential changes over time in…”
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A new animal model for assessing mechanisms and management of muscle hyperalgesia by Kehl, Lois J., Trempe, Thomas M., Hargreaves, Kenneth M.

“…Musculoskeletal pain is one of the most frequent symptoms for which medical assistance is sought. Yet, the majority of our knowledge regarding pain physiology…”
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