Search Results - "Hargrave, Darren R"

A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma by Shou, Yaping, Robinson, Douglas M, Amakye, Dereck D, Rose, Kristine L, Cho, Yoon-Jae, Ligon, Keith L, Sharp, Thad, Haider, Asifa S, Bandaru, Raj, Ando, Yuichi, Geoerger, Birgit, Doz, François, Ashley, David M, Hargrave, Darren R, Casanova, Michela, Tawbi, Hussein A, Rodon, Jordi, Thomas, Anne L, Mita, Alain C, MacDonald, Tobey J, Kieran, Mark W

“…Distinct molecular subgroups of medulloblastoma, including hedgehog (Hh) pathway-activated disease, have been reported. We identified and clinically validated…”
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Phase 2 Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors by Fangusaro, Jason, Cefalo, Maria Giuseppina, Garré, Maria Luisa, Marshall, Lynley V, Massimino, Maura, Benettaib, Bouchra, Biserna, Noha, Poon, Jennifer, Quan, Jackie, Conlin, Erin, Lewandowski, John, Simcock, Mathew, Jeste, Neelum, Hargrave, Darren R, Doz, François, Warren, Katherine E

“…Treatment of recurrent primary pediatric brain tumors remains a major challenge, with most children succumbing to their disease. We conducted a prospective…”
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Quality of health information on the Internet in pediatric neuro-oncology by Hargrave, Darren R, Hargrave, Ursula A, Bouffet, Eric

“…The Internet is now the single largest source of health information and is used by many patients and their families who are affected by childhood brain tumors…”
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Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation-Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study by Hargrave, Darren R, Bouffet, Eric, Tabori, Uri, Broniscer, Alberto, Cohen, Kenneth J, Hansford, Jordan R, Geoerger, Birgit, Hingorani, Pooja, Dunkel, Ira J, Russo, Mark W, Tseng, Lillian, Dasgupta, Kohinoor, Gasal, Eduard, Whitlock, James A, Kieran, Mark W

“…Pediatric low-grade glioma (pLGG) is the most prevalent childhood brain tumor. Patients with V600 mutation-positive pLGG may benefit from treatment with…”
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Dabrafenib plus Trametinib in Pediatric Glioma with BRAF V600 Mutations by Bouffet, Eric, Hansford, Jordan R., Garrè, Maria Luisa, Hara, Junichi, Plant-Fox, Ashley, Aerts, Isabelle, Locatelli, Franco, van der Lugt, Jasper, Papusha, Ludmila, Sahm, Felix, Tabori, Uri, Cohen, Kenneth J., Packer, Roger J., Witt, Olaf, Sandalic, Larissa, Bento Pereira da Silva, Ana, Russo, Mark, Hargrave, Darren R.

“…The use of dabrafenib plus trametinib in pediatric low-grade glioma with BRAF V600 mutations led to longer progression-free survival and fewer grade 3 adverse…”
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Phase II Trial of Dabrafenib Plus Trametinib in Relapsed/Refractory BRAF V600–Mutant Pediatric High-Grade Glioma by Hargrave, Darren R., Terashima, Keita, Hara, Junichi, Kordes, Uwe R., Upadhyaya, Santhosh A., Sahm, Felix, Bouffet, Eric, Packer, Roger J., Witt, Olaf, Sandalic, Larissa, Kieloch, Agnieszka, Russo, Mark, Cohen, Kenneth J., Diez, Blanca, Cappellano, Andrea, Epelman, Sidnei, Mancano, Bruna, Nysom, Karsten, Aerts, Isabelle, Bertozzi, Anne-Isabelle, Witt, Olaf, Kramm, Christof, Fleischhack, Gudrun, Kordes, Uwe, Hernaiz-Driever, Pablo, Massimino, Maura, Garre, Maria Luisa, Locatelli, Franco, Terashima, Keita, Okada, Keiko, Koga, Yuki, Van der Lugt, Jasper, Maschan, Alexey, Lassaletta, Alvaro, Holm, Stefan, Hargrave, Darren, Howell, Lisa, Upadhyaya, Santhosh, Gauvain, Karen, Cohen, Kenneth, Baxter, Patricia

“…PURPOSE BRAF V600 mutation is detected in 5%-10% of pediatric high-grade gliomas (pHGGs), and effective treatments are limited. In previous trials, dabrafenib…”
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Visual outcomes in children with neurofibromatosis type 1-associated optic pathway glioma following chemotherapy: a multicenter retrospective analysis by Fisher, Michael J, Loguidice, Michael, Gutmann, David H, Listernick, Robert, Ferner, Rosalie E, Ullrich, Nicole J, Packer, Roger J, Tabori, Uri, Hoffman, Robert O, Ardern-Holmes, Simone L, Hummel, Trent R, Hargrave, Darren R, Bouffet, Eric, Charrow, Joel, Bilaniuk, Larissa T, Balcer, Laura J, Liu, Grant T

“…Optic pathway gliomas (OPGs) occur in 15%-20% of children with neurofibromatosis type 1 (NF1); up to half become symptomatic. There is little information…”
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Resistance, rebound, and recurrence regrowth patterns in pediatric low-grade glioma treated by MAPK inhibition: A modified Delphi approach to build international consensus-based definitions—International Pediatric Low-Grade Glioma Coalition by O’Hare, Patricia, Cooney, Tabitha, de Blank, Peter, Gutmann, David H, Kieran, Mark, Milde, Till, Fangusaro, Jason, Fisher, Michael, Avula, Shivaram, Packer, Roger, Fukuoka, Kohei, Mankad, Kshitij, Mueller, Sabine, Waanders, Angela J, Opocher, Enrico, Bouffet, Eric, Raabe, Eric, Werle, Natacha Entz, Azizi, Amedeo A, Robison, Nathan J, Hernáiz Driever, Pablo, Russo, Mark, Schouten, Netteke, van Tilburg, Cornelis M, Sehested, Astrid, Grill, Jacques, Bandopadhayay, Pratiti, Kilday, John-Paul, Witt, Olaf, Ashley, David M, Ertl-Wagner, Birgit Betina, Tabori, Uri, Hargrave, Darren R

“…Abstract Pediatric low-grade glioma (pLGG) is the most common childhood brain tumor group. The natural history, when curative resection is not possible, is one…”
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Characterisation of paediatric brain tumours by their MRS metabolite profiles by Gill, Simrandip K, Rose, Heather E L, Wilson, Martin, Rodriguez Gutierrez, Daniel, Worthington, Lara, Davies, Nigel P, MacPherson, Lesley, Hargrave, Darren R, Saunders, Dawn E, Clark, Christopher A, Payne, Geoffrey S, Leach, Martin O, Howe, Franklyn A, Auer, Dorothee P, Jaspan, Tim, Morgan, Paul S, Grundy, Richard G, Avula, Shivaram, Pizer, Barry, Arvanitis, Theodoros N, Peet, Andrew C

“…H-magnetic resonance spectroscopy (MRS) has the potential to improve the noninvasive diagnostic accuracy for paediatric brain tumours. However, studies…”
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Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial by Rodriguez Gutierrez, Daniel, Jones, Chris, Varlet, Pascale, Mackay, Alan, Warren, Daniel, Warmuth-Metz, Monika, Aliaga, Esther Sánchez, Calmon, Raphael, Hargrave, Darren R, Cañete, Adela, Massimino, Maura, Azizi, Amedeo A, Le Deley, Marie-Cécile, Saran, Frank, Rousseau, Raphael F, Zahlmann, Gudrun, Garcia, Josep, Vassal, Gilles, Grill, Jacques, Morgan, Paul S, Jaspan, Tim

“…The HERBY trial evaluated the benefit of the addition of the antiangiogenic agent Bevacizumab (BEV) to radiotherapy/temozolomide (RT/TMZ) in pediatric patients…”
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Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease by Veldhuijzen van Zanten, Sophie E. M., Baugh, Joshua, Chaney, Brooklyn, De Jongh, Dennis, Sanchez Aliaga, Esther, Barkhof, Frederik, Noltes, Johan, De Wolf, Ruben, Van Dijk, Jet, Cannarozzo, Antonio, Damen-Korbijn, Carin M., Lieverst, Jan A., Colditz, Niclas, Hoffmann, Marion, Warmuth-Metz, Monika, Bison, Brigitte, Jones, David T. W., Sturm, Dominik, Gielen, Gerrit H., Jones, Chris, Hulleman, Esther, Calmon, Raphael, Castel, David, Varlet, Pascale, Giraud, Géraldine, Slavc, Irene, Van Gool, Stefaan, Jacobs, Sandra, Jadrijevic-Cvrlje, Filip, Sumerauer, David, Nysom, Karsten, Pentikainen, Virve, Kivivuori, Sanna-Maria, Leblond, Pierre, Entz-Werle, Natasha, von Bueren, Andre O., Kattamis, Antonis, Hargrave, Darren R., Hauser, Péter, Garami, Miklos, Thorarinsdottir, Halldora K., Pears, Jane, Gandola, Lorenza, Rutkauskiene, Giedre, Janssens, Geert O., Torsvik, Ingrid K., Perek-Polnik, Marta, Gil-da-Costa, Maria J., Zheludkova, Olga, Shats, Liudmila, Deak, Ladislav, Kitanovski, Lidija, Cruz, Ofelia, Morales La Madrid, Andres, Holm, Stefan, Gerber, Nicolas, Kebudi, Rejin, Grundy, Richard, Lopez-Aguilar, Enrique, Zapata-Tarres, Marta, Emmerik, John, Hayden, Tim, Bailey, Simon, Biassoni, Veronica, Massimino, Maura, Grill, Jacques, Vandertop, William P., Kaspers, Gertjan J. L., Fouladi, Maryam, Kramm, Christof M., van Vuurden, Dannis G.

“…Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with…”
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Prognostic factors of overall survival in children and adolescents enrolled in dose-finding trials in Europe: An Innovative Therapies for Children with Cancer study by Carceller, Fernando, Bautista, Francisco J, Jiménez, Irene, Hladun-Álvaro, Raquel, Giraud, Cécile, Bergamaschi, Luca, Dandapani, Madhumita, Aerts, Isabelle, Doz, François, Frappaz, Didier, Casanova, Michela, Morland, Bruce, Hargrave, Darren R, Marshall, Lynley V, Vassal, Gilles, Pearson, Andrew D.J, Geoerger, Birgit, Moreno, Lucas

“…Abstract Objectives Dose-finding trials are fundamental to develop novel drugs for children and adolescents with advanced cancer. It is crucial to maximise…”
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A phase 1 study of oral ridaforolimus in pediatric patients with advanced solid tumors by Pearson, Andrew D J, Federico, Sara M, Aerts, Isabelle, Hargrave, Darren R, DuBois, Steven G, Iannone, Robert, Geschwindt, Ryan D, Wang, Ruixue, Haluska, Frank G, Trippett, Tanya M, Geoerger, Birgit

“…Ridaforolimus is an investigational, potent, selective mTOR inhibitor. This study was conducted to determine the recommended phase 2 dose (RP2D), maximum…”
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State of affairs in use of steroids in diffuse intrinsic pontine glioma: an international survey and a review of the literature by Veldhuijzen van Zanten, Sophie E. M., Cruz, Ofelia, Kaspers, Gertjan J. L., Hargrave, Darren R., van Vuurden, Dannis G.

“…Children diagnosed with diffuse intrinsic pontine glioma (DIPG) face a dismal prognosis, with severe neurologic deterioration and inevitable death at a median…”
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Gender as a disease modifier in neurofibromatosis type 1 optic pathway glioma by Fisher, Michael J., Loguidice, Michael, Gutmann, David H., Listernick, Robert, Ferner, Rosalie E., Ullrich, Nicole J., Packer, Roger J., Tabori, Uri, Hoffman, Robert O., Ardern-Holmes, Simone L., Hummel, Trent R., Hargrave, Darren R., Bouffet, Eric, Charrow, Joel, Bilaniuk, Larissa T., Balcer, Laura J., D'Agostino McGowan, Lucy, Liu, Grant T.

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Prospective multicentre evaluation and refinement of an analysis tool for magnetic resonance spectroscopy of childhood cerebellar tumours by Manias, Karen A., Harris, Lisa M., Davies, Nigel P., Natarajan, Kal, MacPherson, Lesley, Foster, Katharine, Brundler, Marie-Anne, Hargrave, Darren R., Payne, Geoffery S., Leach, Martin O., Morgan, Paul S., Auer, Dorothee, Jaspan, Tim, Arvanitis, Theodoros N., Grundy, Richard G., Peet, Andrew C.

“…Background A tool for diagnosing childhood cerebellar tumours using magnetic resonance (MR) spectroscopy peak height measurement has been developed based on…”
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Palliative and end-of-life care for children with diffuse intrinsic pontine glioma: results from a London cohort study and international survey by Veldhuijzen van Zanten, Sophie E M, van Meerwijk, Charlotte L L I, Jansen, Marc H A, Twisk, Jos W R, Anderson, Anna-Karenia, Coombes, Lucy, Breen, Maggie, Hargrave, Olivia J, Hemsley, June, Craig, Finella, Cruz, Ofelia, Kaspers, Gertjan J L, van Vuurden, Dannis G, Hargrave, Darren R

“…More than 90% of patients with diffuse intrinsic pontine glioma (DIPG) will die within 2 years of diagnosis. Patients deteriorate rapidly during the disease…”
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Outcome of children and adolescents with central nervous system tumors in phase I trials by Carceller, Fernando, Bautista, Francisco, Jiménez, Irene, Hladun-Álvaro, Raquel, Giraud, Cécile, Bergamaschi, Luca, Dandapani, Madhumita, Aerts, Isabelle, Doz, François, Frappaz, Didier, Casanova, Michela, Morland, Bruce, Hargrave, Darren R., Vassal, Gilles, Pearson, Andrew D. J., Geoerger, Birgit, Moreno, Lucas, Marshall, Lynley V.

“…Central nervous system (CNS) tumors are a leading cause of death in pediatric oncology. New drugs are desperately needed to improve survival. We evaluated the…”
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Hereditary leiomyomatosis and renal cell carcinoma: very early diagnosis of renal cancer in a paediatric patient by Alrashdi, Ismail, Levine, Samantha, Paterson, Joan, Saxena, Rohit, Patel, Soonie R., Depani, Sarita, Hargrave, Darren R., Pritchard-Jones, Kathy, Hodgson, Shirley V.

“…Hereditary leiomyomatosis and renal cell cancer is a hereditary cancer syndrome in which affected individuals are at risk for cutaneous and uterine leiomyomas,…”
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Pediatric CNS tumors: current treatment and future directions by Hargrave, Darren R, Zacharoulis, Stergios

“…Pediatric CNS tumors are the most common solid tumor of childhood and are the leading cause of cancer-related death in this age group. Improving prognosis is…”
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