Search Results - "Hargest, Virginia"
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Astrovirus-induced epithelial-mesenchymal transition via activated TGF-β increases viral replication
Published in PLoS pathogens (01-04-2022)“…Human astroviruses (HAstV), positive sense single-stranded RNA viruses, are one of the leading causes of diarrhea worldwide. Despite their high prevalence, the…”
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Journal Article -
2
Astrovirus Biology and Pathogenesis
Published in Annual review of virology (29-09-2017)“…Astroviruses are nonenveloped, positive-sense single-stranded RNA viruses that cause gastrointestinal illness. Although a leading cause of pediatric diarrhea,…”
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Journal Article -
3
Astrovirus Pathogenesis
Published in Viruses (22-01-2017)“…Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975,…”
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Journal Article Book Review -
4
Human Astroviruses: A Tale of Two Strains
Published in Viruses (27-02-2021)“…Since the 1970s, eight closely related serotypes of classical human astroviruses (HAstV) have been associated with gastrointestinal illness worldwide. In the…”
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Journal Article -
5
Astrovirus-induced epithelial-mesenchymal transition via activated TGF-[beta] increases viral replication
Published in PLoS pathogens (22-04-2022)“…Human astroviruses (HAstV), positive sense single-stranded RNA viruses, are one of the leading causes of diarrhea worldwide. Despite their high prevalence, the…”
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Journal Article -
6
Astrovirus Replication Is Inhibited by Nitazoxanide In Vitro and In Vivo
Published in Journal of virology (14-02-2020)“…Astroviruses (AstV) are a leading cause of diarrhea, especially in the very young, the elderly, and immunocompromised populations. Despite their significant…”
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Journal Article -
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Astrovirus replication is dependent on induction of double-membrane vesicles through a PI3K-dependent, LC3-independent pathway
Published in Journal of virology (28-09-2023)“…Human astrovirus is a positive-sense, single-stranded RNA virus. Astrovirus infection causes gastrointestinal symptoms and can lead to encephalitis in…”
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Journal Article -
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Understanding Human Astrovirus from Pathogenesis to Treatment
Published 01-01-2020“…While human astroviruses (HAstV) were discovered nearly 45 years ago, these small positive-sense RNA viruses remain critically understudied. These studies…”
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Dissertation -
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Indoleamine 2,3-dioxygenase 1 regulates cell permissivity to astrovirus infection
Published in Mucosal immunology (01-08-2023)“…Astroviruses cause a spectrum of diseases spanning asymptomatic infections to severe diarrhea, but little is understood about their pathogenesis. We previously…”
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Journal Article -
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51: Neurotropic Astrovirus-VA1: Identifying the distinctions from classical genotypes
Published in Journal of the Pediatric Infectious Diseases Society (28-06-2021)“…Abstract Background Human astroviruses (HAstV) are a leading cause of acute gastroenteritis in children, particularly those under the age of 2 or with…”
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Journal Article -
11
Diet-induced obesity affects influenza disease severity and transmission dynamics in ferrets
Published in Science advances (10-05-2024)“…Obesity, and the associated metabolic syndrome, is a risk factor for increased disease severity with a variety of infectious agents, including influenza virus…”
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Journal Article -
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Human Astrovirus VA1 Encephalitis in Pediatric Patients With Cancer: Report of 2 Cases and Review of the Literature
Published in Journal of the Pediatric Infectious Diseases Society (29-09-2022)“…Abstract Novel human astroviruses (HAstVs) have recently been implicated as rare causes of fatal encephalitis in immunocompromised patients, for which there is…”
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Journal Article -
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Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice
Published in Nature microbiology (18-04-2024)“…Metabolic disease is epidemiologically linked to severe complications upon influenza virus infection, thus vaccination is a priority in this high-risk…”
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Journal Article