Search Results - "Harfe, Brian D"

Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons by Huang, Wendy C., Xiao, Shaohua, Huang, Fen, Harfe, Brian D., Jan, Yuh Nung, Jan, Lily Yeh

“…Central neurons respond to synaptic inputs from other neurons by generating synaptic potentials. Once the summated synaptic potentials reach threshold for…”
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Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs by Choi, Kyung-Suk, Harfe, Brian D

“…The vertebrae notochord is a transient rod-like structure that produces secreted factors that are responsible for patterning surrounding tissues. During later…”
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Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis by Bandyopadhyay, Amitabha, Tsuji, Kunikazu, Cox, Karen, Harfe, Brian D, Rosen, Vicki, Tabin, Clifford J

“…Bone morphogenetic protein (BMP) family members, including BMP2, BMP4, and BMP7, are expressed throughout limb development. BMPs have been implicated in early…”
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The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons by Cho, Hawon, Yang, Young Duk, Lee, Jesun, Lee, Byeongjoon, Kim, Tahnbee, Jang, Yongwoo, Back, Seung Keun, Na, Heung Sik, Harfe, Brian D, Wang, Fan, Raouf, Ramin, Wood, John N, Oh, Uhtaek

“…This study reports that the Ca 2+ -activated chloride channel anoctamin 1 (ANO1) is activated by heat and is expressed in mouse dorsal root ganglion neurons…”
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The transmembrane protein TMEM16A is required for normal development of the murine trachea by Rock, Jason R., Futtner, Christopher R., Harfe, Brian D.

“…Pathological collapsibility of the upper airways, caused by many different genetic and environmental insults, is known as tracheomalacia in humans. We…”
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TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression by DUVVURI, Umamaheswar, SHIWARSKI, Daniel J, SCHREIBER, Rainer, SEETHALA, Raja S, EGLOFF, Ann Marie, XING CHEN, LUI, Vivian W, GRANDIS, Jennifer R, GOLLIN, Susanne M, DONG XIAO, BERTRAND, Carol, XIN HUANG, EDINGER, Robert S, ROCK, Jason R, HARFE, Brian D, HENSON, Brian J, KUNZELMANN, Karl

“…Frequent gene amplification of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been reported in several malignancies…”
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Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport by Ousingsawat, Jiraporn, Martins, Joana R., Schreiber, Rainer, Rock, Jason R., Harfe, Brian D., Kunzelmann, Karl

“…Molecular identification of the Ca2+-dependent chloride channel TMEM16A (ANO1) provided a fundamental step in understanding Ca2+-dependent Cl− secretion in…”
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Studies on expression and function of the TMEM16A calcium-activated chloride channel by Huang, Fen, Rock, Jason R, Harfe, Brian D, Cheng, Tong, Huang, Xiaozhu, Jan, Yuh Nung, Jan, Lily Yeh

“…Calcium-activated chloride channels (CaCC) with similar hallmark features are present in many cell types and mediate important physiological functions…”
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BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing by Rosen, Vicki, Tsuji, Kunikazu, Bandyopadhyay, Amitabha, Harfe, Brian D, Cox, Karen, Kakar, Sanjeev, Gerstenfeld, Louis, Einhorn, Thomas, Tabin, Clifford J

“…Adult bones have a notable regenerative capacity. Over 40 years ago, an intrinsic activity capable of initiating this reparative response was found to reside…”
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Conditional Loss of Dicer Disrupts Cellular and Tissue Morphogenesis in the Cortex and Hippocampus by Davis, Tigwa H, Cuellar, Trinna L, Koch, Selina M, Barker, Allison J, Harfe, Brian D, McManus, Michael T, Ullian, Erik M

“…To investigate the role of Dicer and microRNAs in the mammalian CNS, we used mice in which the second RNase III domain of Dicer was conditionally floxed…”
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Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation by Choi, Kyung‐Suk, Cohn, Martin J., Harfe, Brian D.

“…A classically identified “notochordal” cell population in the nucleus pulposus is thought to regulate disk homeostasis. However, the embryonic origin of these…”
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Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular Disease by HARVEY, Scott J, JARAD, George, CUNNINGHAM, Jeanette, GOLDBERG, Seth, SCHERMER, Bernhard, HARFE, Brian D, MCMANUS, Michael T, BENZING, Thomas, MINER, Jeffrey H

“…MicroRNAs (miRNAs) regulate gene expression by binding the 3' untranslated region of mRNAs. To define their role in glomerular function, miRNA biogenesis was…”
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Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles by Hwang, Sung Jin, Blair, Peter J. A., Britton, Fiona C., O’Driscoll, Kate E., Hennig, Grant, Bayguinov, Yulia R., Rock, Jason R., Harfe, Brian D., Sanders, Kenton M., Ward, Sean M.

“…Interstitial cells of Cajal (ICC) generate pacemaker activity (slow waves) in gastrointestinal (GI) smooth muscles, but the mechanism(s) of pacemaker activity…”
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Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus by Peck, Sun H., McKee, Kendra K., Tobias, John W., Malhotra, Neil R., Harfe, Brian D., Smith, Lachlan J.

“…Recapitulation of developmental signals represents a promising strategy for treating intervertebral disc degeneration. During development, embryonic…”
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MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse by LYNN, Francis C, SKEWES-COX, Peter, KOSAKA, Yasuhiro, MCMANUS, Michael T, HARFE, Brian D, GERMAN, Michael S

“…MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse Francis C. Lynn 1 , Peter Skewes-Cox 1 , Yasuhiro Kosaka 1 , Michael T. McManus…”
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Degeneration and regeneration of the intervertebral disc: lessons from development by Smith, Lachlan J, Nerurkar, Nandan L, Choi, Kyung-Suk, Harfe, Brian D, Elliott, Dawn M

“…Degeneration of the intervertebral discs, a process characterized by a cascade of cellular, biochemical, structural and functional changes, is strongly…”
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Dicer1 Is Required for Differentiation of the Mouse Male Germline by Maatouk, Danielle M, Loveland, Kate L, McManus, Michael T, Moore, Karen, Harfe, Brian D

“…MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression. Hundreds of miRNAs are expressed in mammals; however, their…”
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Distinct Stem Cell Populations Regenerate the Follicle and Interfollicular Epidermis by Levy, Vered, Lindon, Catherine, Harfe, Brian D., Morgan, Bruce A.

“…The regeneration of the skin and its appendages is thought to occur by the regulated activation of a dedicated stem cell population. A population of cells in…”
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Transmembrane Protein 16A (TMEM16A) Is a Ca2+-regulated Cl– Secretory Channel in Mouse Airways by Rock, Jason R., O'Neal, Wanda K., Gabriel, Sherif E., Randell, Scott H., Harfe, Brian D., Boucher, Richard C., Grubb, Barbara R.

“…For almost two decades, it has been postulated that calcium-activated Cl– channels (CaCCs) play a role in airway epithelial Cl– secretion, but until recently,…”
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The RNaseIII Enzyme Dicer Is Required for Morphogenesis but Not Patterning of the Vertebrate Limb by Harfe, Brain D., McManus, Michael T., Mansfield, Jennifer H., Hornstein, Eran, Tabin, Clifford J., Leder, Philip

“…The RNaseIII-containing enzyme Dicer is believed to be required for the processing of most, if not all, microRNAs (miRNAs) and for processing long dsRNA into…”
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