Search Results - "Hardy, W Rod"

Temporal regulation of EGF signalling networks by the scaffold protein Shc1 by Zheng, Yong, Zhang, Cunjie, Croucher, David R., Soliman, Mohamed A., St-Denis, Nicole, Pasculescu, Adrian, Taylor, Lorne, Tate, Stephen A., Hardy, W. Rod, Colwill, Karen, Dai, Anna Yue, Bagshaw, Rick, Dennis, James W., Gingras, Anne-Claude, Daly, Roger J., Pawson, Tony

“…Cell-surface receptors frequently use scaffold proteins to recruit cytoplasmic targets, but the rationale for this is uncertain. Activated receptor tyrosine…”
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ShcA Adaptor Protein Promotes Nephrin Endocytosis and Is Upregulated in Proteinuric Nephropathies by Martin, Claire E, Petersen, Kelly A, Aoudjit, Lamine, Tilak, Manali, Eremina, Vera, Hardy, W Rod, Quaggin, Susan E, Takano, Tomoko, Jones, Nina

“…Nephrin is a key structural component of the podocyte slit diaphragm, and proper expression of nephrin on the cell surface is critical to ensure integrity of…”
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Homotypic and heterotypic immune responses to Omicron variant in immunocompromised patients in diverse clinical settings by Ferreira, Victor H., Solera, Javier T., Hu, Queenie, Hall, Victoria G., Arbol, Berta G., Rod Hardy, W., Samson, Reuben, Marinelli, Tina, Ierullo, Matthew, Virk, Avneet Kaur, Kurtesi, Alexandra, Mavandadnejad, Faranak, Majchrzak-Kita, Beata, Kulasingam, Vathany, Gingras, Anne-Claude, Kumar, Deepali, Humar, Atul

“…Immunocompromised patients are predisposed to severe COVID-19. Here we compare homotypic and heterotypic humoral and cellular immune responses to Omicron BA.1…”
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Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune-mediated inflammatory diseases by Dayam, Roya M, Law, Jaclyn C, Goetgebuer, Rogier L, Chao, Gary Yc, Abe, Kento T, Sutton, Mitchell, Finkelstein, Naomi, Stempak, Joanne M, Pereira, Daniel, Croitoru, David, Acheampong, Lily, Rizwan, Saima, Rymaszewski, Klaudia, Milgrom, Raquel, Ganatra, Darshini, Batista, Nathalia V, Girard, Melanie, Lau, Irene, Law, Ryan, Cheung, Michelle W, Rathod, Bhavisha, Kitaygorodsky, Julia, Samson, Reuben, Hu, Queenie, Hardy, W Rod, Haroon, Nigil, Inman, Robert D, Piguet, Vincent, Chandran, Vinod, Silverberg, Mark S, Gingras, Anne-Claude, Watts, Tania H

“…BACKGROUNDLimited information is available on the impact of immunosuppressants on COVID-19 vaccination in patients with immune-mediated inflammatory diseases…”
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Omicron variant neutralizing antibodies following BNT162b2 BA.4/5 versus mRNA-1273 BA.1 bivalent vaccination in patients with end-stage kidney disease by Yau, Kevin, Kurtesi, Alexandra, Qi, Freda, Delgado-Brand, Melanie, Tursun, Tulunay R., Hu, Queenie, Dhruve, Miten, Kandel, Christopher, Enilama, Omosomi, Levin, Adeera, Jiang, Yidi, Hardy, W. Rod, Yuen, Darren A., Perl, Jeffrey, Chan, Christopher T., Leis, Jerome A., Oliver, Matthew J., Colwill, Karen, Gingras, Anne-Claude, Hladunewich, Michelle A.

“…Neutralization of Omicron subvariants by different bivalent vaccines has not been well evaluated. This study characterizes neutralization against Omicron…”
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Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B by Liu, Jun, Budylowski, Patrick, Samson, Reuben, Griffin, Bryan D, Babuadze, Giorgi, Rathod, Bhavisha, Colwill, Karen, Abioye, Jumai A, Schwartz, Jordan A, Law, Ryan, Yip, Lily, Ahn, Sang Kyun, Chau, Serena, Naghibosadat, Maedeh, Arita, Yuko, Hu, Queenie, Yue, Feng Yun, Banerjee, Arinjay, Hardy, W Rod, Mossman, Karen, Mubareka, Samira, Kozak, Robert A, Pollanen, Michael S, Martin Orozco, Natalia, Gingras, Anne-Claude, Marcusson, Eric G, Ostrowski, Mario A

“…Safe and effective vaccines are needed to end the COVID-19 pandemic. Here, we report the preclinical development of a lipid nanoparticle–formulated SARS-CoV-2…”
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Screening for PTB Domain Binding Partners and Ligand Specificity Using Proteome-Derived NPXY Peptide Arrays by Smith, Matthew J., Hardy, W. Rod, Murphy, James M., Jones, Nina, Pawson, Tony

“…ERRATUM ( vol. 27 , p. 4601 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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An Embryonic Stem Cell-Specific NuRD Complex Functions through Interaction with WDR5 by Ee, Ly-Sha, McCannell, Kurtis N., Tang, Yang, Fernandes, Nancy, Hardy, W. Rod, Green, Michael R., Chu, Feixia, Fazzio, Thomas G.

“…The Nucleosome Remodeling and Deacetylase (NuRD) complex is a chromatin regulatory complex that functions as a transcriptional co-repressor in metazoans. The…”
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Combinatorial ShcA Docking Interactions Support Diversity in Tissue Morphogenesis by Hardy, W. Rod, Li, Lingying, Wang, Zhi, Sedy, Jiri, Fawcett, James, Frank, Eric, Kucera, Jan, Pawson, Tony

“…Changes in protein-protein interactions may allow polypeptides to perform unexpected regulatory functions. Mammalian ShcA docking proteins have amino-terminal…”
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The ShcA PTB Domain Functions as a Biological Sensor of Phosphotyrosine Signaling during Breast Cancer Progression by AHN, Ryuhjin, SABOURIN, Valerie, SIEGEL, Peter M, PAWSON, Tony, URSINI-SIEGEL, Josie, HA, Jacqueline R, CORY, Sean, MARIC, Gordana, YOUNG KYUEN IM, HARDY, W. Rod, HONG ZHAO, PARK, Morag, HALLETT, Michael

“…ShcA (SHC1) is an adapter protein that possesses an SH2 and a PTB phosphotyrosine-binding motif. ShcA generally uses its PTB domain to engage activated…”
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Analysis of a Shc Family Adaptor Protein, ShcD/Shc4, That Associates with Muscle-Specific Kinase by Jones, Nina, Hardy, W. Rod, Friese, Matthew B., Jorgensen, Claus, Smith, Matthew J., Woody, Neil M., Burden, Steven J., Pawson, Tony

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier by Bisson, Nicolas, Ruston, Julie, Jeansson, Marie, Vanderlaan, Rachel, Hardy, W Rod, Du, Jianmei, Hussein, Samer M, Coward, Richard J, Quaggin, Susan E, Pawson, Tony

“…The kidney filtration barrier is formed by the combination of endothelial cells, basement membrane and epithelial cells called podocytes. These specialized…”
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The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1 by Smith, Matthew J, Hardy, W Rod, Li, Guang-Yao, Goudreault, Marilyn, Hersch, Steven, Metalnikov, Pavel, Starostine, Andrei, Pawson, Tony, Ikura, Mitsuhiko

“…Adaptor proteins respond to stimuli and recruit downstream complexes using interactions conferred by associated protein domains and linear motifs. The ShcA…”
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Differential serum neutralisation of omicron sublineages in patients receiving prophylaxis with tixagevimab–cilgavimab by Solera, Javier T, Arbol, Berta G, Ferreira, Victor H, Kurtesi, Alexandra, Hu, Queenie, Ierullo, Matthew, Valverde-Zuniga, Adriana, Raslan, Ismail, Nasir, Asma, Grizales, Clara, Hardy, W Rod, Kulasingam, Vathany, Gingras, Anne-Claude, Humar, Atul, Kumar, Deepali

“…[...]the use of this approach depends on the SARS-CoV-2 variant.1 Because of the rapidly changing variants, in-vitro neutralisation data using relative…”
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Omicron BA.4/5 Neutralization and T-Cell Responses in Organ Transplant Recipients After Booster Messenger RNA Vaccine: A Multicenter Cohort Study by Ferreira, Victor H, Ierullo, Matthew, Mavandadnejad, Faranak, Kurtesi, Alexandra, Hu, Queenie, Hardy, W Rod, Hall, Victoria G, Pinzon, Natalia, Yotis, Demitra, Gingras, Anne-Claude, Belga, Sara, Shalhoub, Sarah, Hébert, Marie-Josée, Humar, Atul, Kabbani, Dima, Kumar, Deepali

“…Abstract Background In solid organ transplant (SOT) recipients, the primary vaccination series against Coronavirus Disease 2019 is 3 doses followed by…”
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Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites by Colwill, Karen, Wells, Clark D, Elder, Kelly, Goudreault, Marilyn, Hersi, Kadija, Kulkarni, Sarang, Hardy, W Rod, Pawson, Tony, Morin, Gregg B

“…Recombinational systems have been developed to rapidly shuttle Open Reading Frames (ORFs) into multiple expression vectors in order to analyze the large number…”
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ShcA signalling is essential for tumour progression in mouse models of human breast cancer by Ursini-Siegel, Josie, Hardy, W Rod, Zuo, Dongmei, Lam, Sonya H L, Sanguin-Gendreau, Virginie, Cardiff, Robert D, Pawson, Tony, Muller, William J

“…To explore the in vivo significance of ShcA during mammary tumorigenesis, we used mice expressing several phosphotyrosine‐deficient ShcA alleles under the…”
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Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development by Chan, Richard, Hardy, W Rod, Dankort, David, Laing, Michael A, Muller, William J

“…We have generated a series of Erbb2 cDNA knock-in animals to explore the role of signaling pathways coupled to Erbb2 during development. Although this knock-in…”
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Distinct Phosphotyrosine-dependent Functions of the ShcA Adaptor Protein Are Required for Transforming Growth Factor β (TGFβ)-induced Breast Cancer Cell Migration, Invasion, and Metastasis by Northey, Jason J., Dong, Zhifeng, Ngan, Elaine, Kaplan, Andrew, Hardy, W. Rod, Pawson, Tony, Siegel, Peter M.

“…The ErbB2 and TGFβ signaling pathways cooperate to promote the migratory, invasive, and metastatic behavior of breast cancer cells. We previously demonstrated…”
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UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways by Culotti, Joseph G, MacNeil, Lesley T, Hardy, W Rod, Pawson, Tony, Wrana, Jeffrey L

“…In the worm, netrin and the TGFβ-related molecule UNC-129 form opposing dorsoventral gradients. Motor axons are repelled by netrin and attracted to UNC-129,…”
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