Search Results - "Hardy, Matthew P."

A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk by Larsson, Magnus, Rayzman, Veronika, Nolte, Marc W, Nickel, Katrin F, Björkqvist, Jenny, Jämsä, Anne, Hardy, Matthew P, Fries, Marion, Schmidbauer, Stefan, Hedenqvist, Patricia, Broomé, Michael, Pragst, Ingo, Dickneite, Gerhard, Wilson, Michael J, Nash, Andrew D, Panousis, Con, Renné, Thomas

“…Currently used anticoagulants prevent thrombosis but increase bleeding. We show an anticoagulation therapy without bleeding risk based on a plasma protease…”
Get more information

The core domain of hepatitis C virus glycoprotein E2 generates potent cross‐neutralizing antibodies in guinea pigs by Vietheer, Patricia T., Boo, Irene, Gu, Jun, McCaffrey, Kathleen, Edwards, Stirling, Owczarek, Catherine, Hardy, Matthew P., Fabri, Louis, Center, Rob J., Poumbourios, Pantelis, Drummer, Heidi E.

“…A vaccine that prevents hepatitis C virus (HCV) infection is urgently needed to support an emerging global elimination program. However, vaccine development…”
Get full text

Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons by Barnes, If H A, Ibarra-Soria, Ximena, Fitzgerald, Stephen, Gonzalez, Jose M, Davidson, Claire, Hardy, Matthew P, Manthravadi, Deepa, Van Gerven, Laura, Jorissen, Mark, Zeng, Zhen, Khan, Mona, Mombaerts, Peter, Harrow, Jennifer, Logan, Darren W, Frankish, Adam

“…Olfactory receptor (OR) genes are the largest multi-gene family in the mammalian genome, with 874 in human and 1483 loci in mouse (including pseudogenes). The…”
Get full text

The Molecular Mechanisms of Complement Receptor 1—It Is Complicated by Hardy, Matthew P., Mansour, Mariam, Rowe, Tony, Wymann, Sandra

“…Human complement receptor 1 (CR1) is a membrane-bound regulator of complement that has been the subject of recent attempts to generate soluble therapeutic…”
Get full text

A potent truncated form of human soluble CR1 is protective in a mouse model of renal ischemia–reperfusion injury by Bongoni, Anjan K., Vikstrom, Ingela B., McRae, Jennifer L., Salvaris, Evelyn J., Fisicaro, Nella, Pearse, Martin J., Wymann, Sandra, Rowe, Tony, Morelli, Adriana Baz, Hardy, Matthew P., Cowan, Peter J.

“…The complement system is a potent mediator of ischemia–reperfusion injury (IRI), which detrimentally affects the function and survival of transplanted kidneys…”
Get full text

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling by Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Kan, Winnie L., Barry, Emma F., Dottore, Mara, Cheung Tung Shing, Karen S., Morton, Craig J., Dhagat, Urmi, Hardy, Matthew P., Wilson, Nicholas J., Downton, Matthew T., Schieber, Christine, Hughes, Timothy P., Lopez, Angel F., Parker, Michael W.

“…The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and…”
Get full text

The combination of ISCOMATRIX adjuvant and TLR agonists induces regression of established solid tumors in vivo by Silva, Anabel, Mount, Adele, Krstevska, Karoline, Pejoski, David, Hardy, Matthew P, Owczarek, Catherine, Scotney, Pierre, Maraskovsky, Eugene, Baz Morelli, Adriana

“…The development of therapeutic vaccines for treatment of established cancer has proven challenging. Cancer vaccines not only need to induce a robust tumor…”
Get full text

Phthalate-Induced Leydig Cell Hyperplasia Is Associated with Multiple Endocrine Disturbances by Akingbemi, Benson T., Ge, Renshan, Klinefelter, Gary R., Zirkin, Barry R., Hardy, Matthew P.

“…The possibility that exposures to environmental agents are associated with reproductive disorders in human populations has generated much public interest…”
Get full text

In Search of Rat Stem Leydig Cells: Identification, Isolation, and Lineage-Specific Development by Ge, Ren-Shan, Dong, Qiang, Sottas, Chantal M., Papadopoulos, Vassilios, Zirkin, Barry R., Hardy, Matthew P.

“…Leydig cells (LCs) are thought to differentiate from spindle-shaped precursor cells that exhibit some aspects of differentiated function, including…”
Get full text

Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero by Lin, Han, Ge, Ren-Shan, Chen, Guo-Rong, Hu, Guo-Xin, Dong, Lei, Lian, Qing-Quan, Hardy, Dianne O, Sottas, Chantal M, Li, Xiao-Kun, Hardy, Matthew P

“…Exposures to di-(2-ethylhexyl) phthalate (DEHP) have been shown to be associated with decreased adult testosterone (T) levels and increased Leydig cell…”
Get full text

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins by Trezise, Stephanie, Karnowski, Alexander, Fedele, Pasquale L, Mithraprabhu, Sridurga, Liao, Yang, D'Costa, Kathy, Kueh, Andrew J, Hardy, Matthew P, Owczarek, Catherine M, Herold, Marco J, Spencer, Andrew, Shi, Wei, Willis, Simon N, Nutt, Stephen L, Corcoran, Lynn M

“…Antibody Secreting Cells (ASCs) are a fundamental component of humoral immunity, however, deregulated or excessive antibody production contributes to the…”
Get full text

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody by Broughton, Sophie E., Hercus, Timothy R., Hardy, Matthew P., McClure, Barbara J., Nero, Tracy L., Dottore, Mara, Huynh, Huy, Braley, Hal, Barry, Emma F., Kan, Winnie L., Dhagat, Urmi, Scotney, Pierre, Hartman, Dallas, Busfield, Samantha J., Owczarek, Catherine M., Nash, Andrew D., Wilson, Nicholas J., Parker, Michael W., Lopez, Angel F.

“…Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the…”
Get full text

Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics by Schaer, Christian A, Owczarek, Catherine, Deuel, Jeremy W, Schauer, Stefan, Baek, Jin Hyen, Yalamanoglu, Ayla, Hardy, Matthew P, Scotney, Pierre D, Schmidt, Peter M, Pelzing, Matthias, Soupourmas, Peter, Buehler, Paul W, Schaer, Dominik J

“…Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free…”
Get full text

Characterization of the type I interferon locus and identification of novel genes by Hardy, Matthew P., Owczarek, Catherine M., Jermiin, Lars S., Ejdebäck, Mikael, Hertzog, Paul J.

“…The human type I interferon (IFN) genes are clustered on human chromosome 9p21 and the mouse genes are located in the region of conserved synteny on mouse…”
Get full text

The role of the Leydig cell in spermatogenic function by Ge, Renshan, Chen, Guorong, Hardy, Matthew P

Get more information

Gene Expression in Rat Leydig Cells During Development from the Progenitor to Adult Stage: A Cluster Analysis by GE, Ren-Shan, QIANG DONG, SOTTAS, Chantal M, HAOLIN CHEN, ZIRKIN, Barry R, HARDY, Matthew P

“…The postnatal development of Leydig cells can be divided into three distinct stages: initially they exist as fibroblast-like progenitor Leydig cells (PLCs)…”
Get full text

The Murine Irak2 Gene Encodes Four Alternatively Spliced Isoforms, Two of Which Are Inhibitory by Hardy, Matthew P., O'Neill, Luke A.J.

“…The interleukin-1 receptor-associated kinases (IRAKs) are important downstream signaling components of Toll-like receptors (TLRs). To date, four mammalian…”
Get full text

Development of Leydig Cells in the Insulin-Like Growth Factor-I (IGF-I) Knockout Mouse: Effects of IGF-I Replacement and Gonadotropic Stimulation by Wang, Guimin, Hardy, Matthew P

“…Targeted gene deletion of insulin-like growth factor-I (IGF-I) results in diminished numbers of Leydig cells (LCs) and lower circulating testosterone (T)…”
Get full text

Variation in the End Products of Androgen Biosynthesis and Metabolism during Postnatal Differentiation of Rat Leydig Cells by Ge, Ren-Shan, Hardy, Matthew P.

“…Abstract The amount of testosterone (T) secreted by Leydig cells is determined by a balance between T biosynthetic and metabolizing enzyme activities. It has…”
Get full text

In Utero and Lactational Exposures to Diethylhexyl-Phthalate Affect Two Populations of Leydig Cells in Male Long-Evans Rats by Lin, Han, Lian, Qing-Quan, Hu, Guo-Xin, Jin, Yuan, Zhang, Yunhui, Hardy, Dianne O, Chen, Guo-Rong, Lu, Zhong-Qiu, Sottas, Chantal M, Hardy, Matthew P, Ge, Ren-Shan

“…Diethylhexylphthalate (DEHP) has been classified as an antiandrogen. However, whether in utero and lactational exposures of DEHP affect Leydig cells has not…”
Get full text