Search Results - "Hardy, John"

The discovery of Alzheimer‐causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis” by Hardy, John

“…The cloning of APP and genetic analysis of families with Alzheimer's disease were both reported in 1987 and much present work on the disease is based upon the…”
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amyloid hypothesis for Alzheimer's disease: a critical reappraisal by Hardy, John

“…The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer's disease. Recent clinical trials based on this hypothesis have been…”
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A Hundred Years of Alzheimer's Disease Research by Hardy, John

“…On the 100 th anniversary of Alzheimer's lecture describing the clinicopathological entity which bears his eponym, this article reviews the major areas of…”
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The amyloid hypothesis of Alzheimer's disease at 25 years by Selkoe, Dennis J, Hardy, John

“…Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that…”
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A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease by Karran, Eric, Hardy, John

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Metallosupramolecular grid complexes: towards nanostructured materials with high-tech applications by Hardy, John G

“…Metallosupramolecular grid complexes (hereafter referred to as metallogrids) are well-defined oligonuclear metal ion complexes involving essentially planar…”
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Genomewide Association Studies and Human Disease by Hardy, John, Singleton, Andrew

“…Genomewide association studies have uncovered many genetic variants that confer susceptibility to disease. This article describes the genomewide association…”
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The Neuropathology and Neurobiology of Traumatic Brain Injury by Blennow, Kaj, Hardy, John, Zetterberg, Henrik

“…The acute and long-term consequences of traumatic brain injury (TBI) have received increased attention in recent years. In this Review, we discuss the…”
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Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk by Hardy, John

“…As we identify the loci involved in late onset neurodegenerative disease, we are finding that the majority of them are involved in damage response processes…”
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The Evolution of Genetics: Alzheimer’s and Parkinson’s Diseases by Singleton, Andrew, Hardy, John

“…Genetic discoveries underlie the majority of the current thinking in neurodegenerative disease. This work has been driven by the significant gains made in…”
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Has the amyloid cascade hypothesis for Alzheimer's disease been proved? by Hardy, John

“…After much initial debate for and against the role of amyloid in Alzheimer's disease (AD), mutations on the amyloid precursor protein (APP) and processing…”
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Thematic analysis of in-group and out-group debates in an online right-wing extremist community by Hardy, John

“…The resurgence of Right-Wing Extremism (RWE) has become a cause for concern in Western countries during the 21st century. An increase in white nationalist…”
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Progress in the genetic analysis of Parkinson’s disease by Singleton, Andrew, Hardy, John

“…Abstract The pace of genetic discovery in complex disease has accelerated exponentially over the last decade. Our fund of knowledge of the foundational…”
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Polygenic risk score analysis of pathologically confirmed Alzheimer disease by Escott‐Price, Valentina, Myers, Amanda J., Huentelman, Matt, Hardy, John

“…Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzheimer disease have given area under the curve (AUC) estimates of…”
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Apolipoprotein E in Alzheimer's disease: an update by Yu, Jin-Tai, Tan, Lan, Hardy, John

“…The vast majority of Alzheimer's disease (AD) cases are late onset (LOAD), which is genetically complex with heritability estimates up to 80%. Apolipoprotein E…”
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Genetics and molecular mechanisms of frontotemporal lobar degeneration: an update and future avenues by Ferrari, Raffaele, Manzoni, Claudia, Hardy, John

“…Frontotemporal lobar degeneration (FTLD) is the second most common form of dementia after Alzheimer's disease. The study and the dissection of FTLD is complex…”
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Biomimetic conducting polymer-based tissue scaffolds by Hardy, John G, Lee, Jae Y, Schmidt, Christine E

“…Graphical abstract…”
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Smartphone-based colorimetric detection systems for glucose monitoring in the diagnosis and management of diabetes by Kap, Özlem, Kılıç, Volkan, Hardy, John G, Horzum, Nesrin

“…Diabetes is a group of metabolic conditions resulting in high blood sugar levels over prolonged periods that affects hundreds of millions of patients…”
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Responsive Biomaterials: Advances in Materials Based on Shape-Memory Polymers by Hardy, John G., Palma, Matteo, Wind, Shalom J., Biggs, Manus J.

“…Shape‐memory polymers (SMPs) are morphologically responsive materials with potential for a variety of biomedical applications, particularly as devices for…”
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Single-cell RNA sequencing analysis of human Alzheimer's disease brain samples reveals neuronal and glial specific cells differential expression by Soreq, Lilach, Bird, Hannah, Mohamed, Wael, Hardy, John

“…Alzheimer's disease is the most common neurological disease worldwide. Unfortunately, there are currently no effective treatment methods nor early detection…”
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