Search Results - "Hardy, Ian R"

Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies by Rodgers, David T., Mazagova, Magdalena, Hampton, Eric N., Cao, Yu, Ramadoss, Nitya S., Hardy, Ian R., Schulman, Andrew, Du, Juanjuan, Wang, Feng, Singer, Oded, Ma, Jennifer, Nunez, Vanessa, Shen, Jiayin, Woods, Ashley K., Wright, Timothy M., Schultz, Peter G., Kim, Chan Hyuk, Young, Travis S.

“…Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related…”
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Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory by Viaud, Sophie, Ma, Jennifer S. Y., Hardy, Ian R., Hampton, Eric N., Benish, Brent, Sherwood, Lance, Nunez, Vanessa, Ackerman, Christopher J., Khialeeva, Elvira, Weglarz, Meredith, Lee, Sung Chang, Woods, Ashley K., Young, Travis S.

“…Chimeric antigen receptor (CAR) T cells with a long-lived memory phenotype are correlated with durable, complete remissions in patients with leukemia. However,…”
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Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic Antibodies Using a Humanized CD79 Mouse Model by Wemlinger, Scott M, Parker Harp, Chelsea R, Yu, Bo, Hardy, Ian R, Seefeldt, Matthew, Matsuda, Jennifer, Mingueneau, Michael, Spilker, Kerri A, Cameron, Thomas O, Larrick, James W, Getahun, Andrew, Cambier, John C

“…The BCR comprises a membrane-bound Ig that is noncovalently associated with a heterodimer of CD79A and CD79B. While the BCR Ig component functions to sense…”
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Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target by Young, Ryan M., Hardy, Ian R., Clarke, Raedun L., Lundy, Nicolai, Pine, Polly, Turner, Brian C., Potter, Terry A., Refaeli, Yosef

“…We have generated mouse models of non-Hodgkin lymphoma (NHL) that rely on the cooperation between MYC overexpression and B-cell antigen receptor (BCR)…”
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Implications of T cell receptor biology on the development of new T cell therapies for cancer by Hardy, Ian R, Schamel, Wolfgang W, Baeuerle, Patrick A, Getts, Daniel R, Hofmeister, Robert

“…Recently, two chimeric antigen receptor (CAR) T cell therapies were approved based on their remarkable efficacy in patients with hematological malignancies. By…”
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Anti-CD79 antibody induces B cell anergy that protects against autoimmunity by Hardy, Ian R, Anceriz, Nadia, Rousseau, François, Seefeldt, Matt B, Hatterer, Eric, Irla, Magali, Buatois, Vanessa, Chatel, Laurence E, Getahun, Andrew, Fletcher, Ashley, Cons, Laura, Pontini, Guillemette, Hertzberg, Nicole A, Magistrelli, Giovanni, Malinge, Pauline, Smith, Mia J, Reith, Walter, Kosco-Vilbois, Marie H, Ferlin, Walter G, Cambier, John C

“…B cells play a major role in the pathogenesis of many autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis,…”
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αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells by O'Brien, Rebecca L, Chain, Jennifer L, Aydintug, M Kemal, Bohrer-Kunter, Dawn, Huang, Yafei, Hardy, Ian R, Cambier, John C, Lahmers, Kevin, Nuhsbaum, Tanja, Davidson, Richard, Sun, Deming, Born, Willi K

“…To investigate additional factors in the spontaneous development of keratitis previously reported in B10.TCRδ⁻/⁻ female mice. The study tested whether…”
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Therapeutic potential of anti-CD79B antibodies by Hardy, Ian R

“…CD79 has come under investigation recently as a target for antibody therapy. Unlike anti-CD20 antibody therapy (CD20-AT), anti-CD79 antibody therapy (CD79-AT)…”
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Local anesthesia with conscious sedation for laparoscopic intrafallopian transfer by Milki, A A, Hardy, R I, el Danasouri, I, Giudice, L C, Lamb, E J

“…Local anesthesia with conscious sedation is well accepted by patients and provides scheduling flexibility, cost containment, patient safety, and ease of…”
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