Search Results - "Hardy, David"
-
1
Comparative Study of Injury Models for Studying Muscle Regeneration in Mice
Published in PloS one (01-01-2016)“…A longstanding goal in regenerative medicine is to reconstitute functional tissues or organs after injury or disease. Attention has focused on the…”
Get full text
Journal Article -
2
HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA)
Published in Nature communications (08-01-2021)“…The Intact Proviral DNA Assay (IPDA) was developed to address the critical need for a scalable method for intact HIV-1 reservoir quantification. This droplet…”
Get full text
Journal Article -
3
TopoGromacs: Automated Topology Conversion from CHARMM to GROMACS within VMD
Published in Journal of chemical information and modeling (27-06-2016)“…Molecular dynamics (MD) simulation engines use a variety of different approaches for modeling molecular systems with force fields that govern their dynamics…”
Get full text
Journal Article -
4
GPU-accelerated molecular modeling coming of age
Published in Journal of molecular graphics & modelling (01-09-2010)“…[Display omitted] ▶ GPUs have become powerful accelerators for molecular modeling applications. ▶ GPUs provide better price-performance than traditional…”
Get full text
Journal Article -
5
BCL-2 antagonism sensitizes cytotoxic T cell-resistant HIV reservoirs to elimination ex vivo
Published in The Journal of clinical investigation (01-05-2020)“…Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses…”
Get full text
Journal Article -
6
Membrane protein extraction and purification using styrene-maleic acid (SMA) copolymer: effect of variations in polymer structure
Published in Biochemical journal (01-12-2016)“…The use of styrene-maleic acid (SMA) copolymers to extract and purify transmembrane proteins, while retaining their native bilayer environment, overcomes many…”
Get more information
Journal Article -
7
py-MCMD: Python Software for Performing Hybrid Monte Carlo/Molecular Dynamics Simulations with GOMC and NAMD
Published in Journal of chemical theory and computation (09-08-2022)“…py-MCMD, an open-source Python software, provides a robust workflow layer that manages communication of relevant system information between the simulation…”
Get full text
Journal Article -
8
Boosting Free-Energy Perturbation Calculations with GPU-Accelerated NAMD
Published in Journal of chemical information and modeling (23-11-2020)“…Harnessing the power of graphics processing units (GPUs) to accelerate molecular dynamics (MD) simulations in the context of free-energy calculations has been…”
Get full text
Journal Article -
9
Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study
Published in The Lancet (British edition) (02-03-2013)“…Summary Background Dolutegravir (S/GSK1349572) is a once-daily HIV integrase inhibitor with potent antiviral activity and a favourable safety profile. We…”
Get full text
Journal Article -
10
High-Performance Scalable Molecular Dynamics Simulations of a Polarizable Force Field Based on Classical Drude Oscillators in NAMD
Published in The journal of physical chemistry letters (20-01-2011)“…Incorporating the influence of induced polarization in large-scale atomistic molecular dynamics (MD) simulations is a critical challenge in the progress toward…”
Get full text
Journal Article -
11
Hidden Biomass of Intact Malaria Parasites in the Human Spleen
Published in The New England journal of medicine (27-05-2021)“…In this report, patients living in a malaria-endemic area underwent trauma-related splenectomy. In these asymptomatic patients who were naturally infected with…”
Get full text
Journal Article -
12
Experimental Investigation of a Novel Solar Micro-Channel Loop-Heat-Pipe Photovoltaic/Thermal (MC-LHP-PV/T) System for Heat and Power Generation
Published in Applied energy (15-12-2019)“…•A novel MC-LHP-PV/T heat and power system was experimentally investigated.•New PV/T system achieved 18.55% higher solar efficiency compared to existing…”
Get full text
Journal Article -
13
Contemporary management and natural history of aberrant right subclavian artery
Published in Journal of vascular surgery (01-04-2022)“…An aberrant right subclavian artery (ARSA) is the most common congenital anomaly of the aortic arch. A paucity of reported studies is available regarding the…”
Get full text
Journal Article -
14
Brain and cognitive reserve: Mediator(s) and construct validity, a critique
Published in Journal of clinical and experimental neuropsychology (01-01-2011)“…The concept of "reserve" has traditionally been defined on the basis of a single indicator (e.g., education or intracranial volume) that purports to moderate…”
Get full text
Journal Article -
15
Accelerating molecular modeling applications with graphics processors
Published in Journal of computational chemistry (01-12-2007)“…Molecular mechanics simulations offer a computational approach to study the behavior of biomolecules at atomic detail, but such simulations are limited in size…”
Get full text
Journal Article -
16
Neuroergonomics: A Perspective from Neuropsychology, with a Proposal about Workload
Published in Brain sciences (15-05-2021)“…In a brief overview of neuroergonomics, including some personal reminiscences of Raja Parasuraman, it is recognized that the field of human factors and…”
Get full text
Journal Article -
17
Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study
Published in PLoS medicine (26-05-2021)“…A very large biomass of intact asexual-stage malaria parasites accumulates in the spleen of asymptomatic human individuals infected with Plasmodium vivax. The…”
Get full text
Journal Article -
18
Physical, Emotional, and Psychosocial Challenges Associated with Daily Dosing of HIV Medications and Their Impact on Indicators of Quality of Life: Findings from the Positive Perspectives Study
Published in AIDS and behavior (01-03-2021)“…To assess challenges with daily oral antiretroviral therapy (ART), we analyzed data for 2389 participants in the 2019 Positive Perspectives survey of people…”
Get full text
Journal Article -
19
Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice
Published in Nature communications (11-05-2021)“…Allergic asthma is characterized by elevated levels of IgE antibodies, type 2 cytokines such as interleukin-4 (IL-4) and IL-13, airway hyperresponsiveness…”
Get full text
Journal Article -
20
Proton minibeam radiation therapy spares normal rat brain: Long-Term Clinical, Radiological and Histopathological Analysis
Published in Scientific reports (31-10-2017)“…Proton minibeam radiation therapy (pMBRT) is a novel strategy for minimizing normal tissue damage resulting from radiotherapy treatments. This strategy…”
Get full text
Journal Article