Search Results - "Hardwick, Simon J."

Changes in vimentin in human macrophages during apoptosis induced by oxidised low density lipoprotein by Müller, Karin, Dulku, Simon, Hardwick, Simon J, Skepper, Jeremy N, Mitchinson, Malcolm J

“…Macrophage apoptosis contributes to the development of human atherosclerotic lesions. Oxidised LDL may be involved in macrophage death in vivo. We examined…”
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Carotenoids inhibit DNA synthesis in human aortic smooth muscle cells by Carpenter, Keri L.H, Hardwick, Simon J, Albarani, Valentina, Mitchinson, Malcolm J

“…Quiescent, serum-starved human aortic smooth muscle cells were restimulated with 20% foetal calf serum in Dulbecco's modified Eagle medium, in the presence and…”
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APOPTOSIS IN HUMAN MONOCYTE-MACROPHAGES EXPOSED TO OXIDIZED LOW DENSITY LIPOPROTEIN by HARDWICK, SIMON J., HEGYI, LASZLO, CLARE, KATHARINE, LAW, NADINE S., CARPENTER, KERI L. H., MITCHINSON, MALCOLM J., SKEPPER, JEREMY N.

“…This study has demonstrated the toxicity to human monocyte‐macrophages of low‐density lipoprotein (LDL) which had been artificially oxidized using copper…”
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Toxicity of oxysterols to human monocyte-macrophages by Clare, Katharine, Hardwick, Simon J., Carpenter, Keri L.H., Weeratunge, Nishanthi, Mitchinson, Malcolm J.

“…We have investigated the toxicity of the cholesterol oxidation products (oxysterols), 7α-hydroxycholesterol, 7β-hydroxycholesterol, 7-ketocholesterol,…”
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Cell death in atherosclerotic plaques by Mitchinson, M J, Hardwick, S J, Bennett, M R

“…The investigation of the mechanisms of cell death in atherosclerosis has recently received added impetus with the realization that apoptosis is probably the…”
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Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro by WHYTE, M. K. B, HARDWICK, S. J, MEAGHER, L. C, SAVILL, J. S, HASLETT, C

“…Elevation of cytosolic calcium ([Ca2+]i) has been reported to induce apoptosis in a number of cell types. However, in the neutrophil, which undergoes apoptosis…”
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Fragmentation of DNA in P388D1 macrophages exposed to oxidised low‐density lipoprotein by Reid, Vanessa C., Hardwick, Simon J., Mitchinson, Malcolm J.

“…Exposing a macrophage‐like murine cell line to copper‐oxidised low‐density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca2+/Mg2+…”
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Changes in elemental concentrations are associated with early stages of apoptosis in human monocyte-macrophages exposed to oxidized low-density lipoprotein: an X-ray microanalytical study by Skepper, Jeremy N., Karydis, Ioannis, Garnett, Matthew R., Hegyi, Laszlo, Hardwick, Simon J., Warley, Alice, Mitchinson, Malcolm J., Cary, Nat R. B.

“…This study examines ion homeostasis in monocyte–macrophages committed to death by apoptosis. X‐ray microanalysis has been used to demonstrate that…”
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Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte-macrophages by Müller, Karin, Hardwick, Simon J., Marchant, Christine E., Law, Nadine S., Waeg, Georg, Esterbauer, Hermann, Carpenter, Keri L.H., Mitchinson, Malcolm J.

“…We have investigated the cytotoxic and chemotactic potencies of malondialdehyde (MDA), hexanal, 4-hydroxyhexenal (HHE), 4-hydroxynonenal (HNE) and…”
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Oxidized low-density lipoprotein is cytotoxic to human monocyte-macrophages: protection with lipophilic antioxidants by Marchant, Christine E., Law, Nadine S., van der Veen, Carina, Hardwick, Simon J., Carpenter, Keri L.H., Mitchinson, Malcolm J.

“…Human monocyte-macrophages were incubated for 24 h with low-density lipoprotein (LDL) which had been previously oxidized for varying periods up to 24 h with…”
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The presence of apoptotic cells in human atherosclerotic lesions by Hegyi, L, Hardwick, S J, Mitchinson, M J, Skepper, J N

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Glutathione (GSH) and the toxicity of oxidised low-density lipoprotein to human monocyte-macrophages by Hardwick, S J, Carpenter, K L, Allen, E A, Mitchinson, M J

“…Macrophage death, believed to be an important event in the pathogenesis of human atherosclerosis, can be induced by oxidised low-density lipoprotein (LDL) in…”
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Toxicity of polyunsaturated fatty acid esters for human monocyte-macrophages: the anomalous behaviour of cholesteryl linolenate by Hardwick, S J, Carpenter, K L, Law, N S, Van Der Veen, C, Marchant, C E, Hird, R, Mitchinson, M J

“…We have investigated the toxicity to human monocytemacrophages, and susceptibility to oxidation, of different individual dietary fatty acids in cholesterol…”
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Fragmentation of DNA in P388D 1 macrophages exposed to oxidised low-density lipoprotein by Reid, Vanessa C., Hardwick, Simon J., Mitchinson, Malcolm J.

“…Exposing a macrophage-like murine cell line to copper-oxidised low-density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca 2+/Mg 2+…”
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Oxidation of low-density lipoprotein by human monocyte-macrophages results in toxicity to the oxidising culture by Marchant, C E, Van der Veen, C, Law, N S, Hardwick, S J, Carpenter, K L, Mitchinson, M J

“…Human monocyte-macrophage cultures were exposed to native low density lipoprotein (LDL) for up to 24 h in Ham's F10 medium and the extent of cell-mediated LDL…”
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The role of glutathione in the biochemical mechanism of paraquat toxicity and of other toxicants in the lung by Hardwick, Simon J

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Protection of rats against the effects of alpha-naphthylthiourea (ANTU) by elevation of non-protein sulphydryl levels by Hardwick, S J, Skamarauskas, J T, Smith, L L, Upshall, D G, Cohen, G M

“…We have investigated the influence of the elevation of pulmonary glutathione (GSH) levels on the toxicity of the rodenticide alpha-naphthylthiourea (ANTU) to…”
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Paracetamol toxicity in hamster isolated hepatocytes : the increase in cytosolic calcium accompanies rather than precedes, loss of viability by HARDWICK, S. J, WILSON, J. W, FAWTHROP, D. J, BOOBIS, A. R, DAVIES, D. S

“…Paracetamol is cytotoxic to hamster isolated hepatocytes by a mechanism that does not involve an early increase in [Ca2+]i. Although an increase in [Ca2+]i…”
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Cell death (methods in cell biology, vol. 46) by Hardwick, Simon J.

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Potentiation of the cell specific toxicity of paraquat by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Implications for the heterogeneous distribution of glutathione (GSH) in rat lung by Hardwick, S J, Adam, A, Smith, L L, Cohen, G M

“…In order to study oxidative stress in the lung, we have developed a rat lung slice model with compromised oxidative defences. Lung slices with markedly…”
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