Search Results - "Hardwick, J. C.H."

Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer by Paauwe, M, Heijkants, R C, Oudt, C H, van Pelt, G W, Cui, C, Theuer, C P, Hardwick, J C H, Sier, C F M, Hawinkels, L J A C

“…Endoglin, a transforming growth factor-β co-receptor, is highly expressed on angiogenic endothelial cells in solid tumors. Therefore, targeting endoglin is…”
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Endoscopic tri-modal imaging for surveillance in ulcerative colitis: randomised comparison of high-resolution endoscopy and autofluorescence imaging for neoplasia detection; and evaluation of narrow-band imaging for classification of lesions by van den Broek, F J C, Fockens, P, van Eeden, S, Reitsma, J B, Hardwick, J C H, Stokkers, P C F, Dekker, E

“…Endoscopic tri-modal imaging (ETMI) incorporates white light endoscopy (WLE), autofluorescence imaging (AFI) and narrow-band imaging (NBI). To assess the value…”
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The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC by Voorneveld, P W, Kodach, L L, Jacobs, R J, van Noesel, C J M, Peppelenbosch, M P, Korkmaz, K S, Molendijk, I, Dekker, E, Morreau, H, van Pelt, G W, Tollenaar, R A E M, Mesker, W, Hawinkels, L J A C, Paauwe, M, Verspaget, H W, Geraets, D T, Hommes, D W, Offerhaus, G J A, van den Brink, G R, ten Dijke, P, Hardwick, J C H

“…Background: Constitutive Wnt activation is essential for colorectal cancer (CRC) initiation but also underlies the cancer stem cell phenotype, metastasis and…”
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Report of the fifth meeting of the European Consortium 'Care for CMMRD' (C4CMMRD), Leiden, The Netherlands, July 6th 2019 by Suerink, M., Wimmer, K., Brugieres, L., Colas, C., Gallon, R., Ripperger, T., Benusiglio, P. R., Bleiker, E. M. A., Ghorbanoghli, Z., Goldberg, Y., Hardwick, J. C. H., Kloor, M., le Mentec, M., Muleris, M., Pineda, M., Ruiz-Ponte, C., Vasen, H. F. A.

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MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients by Langers, A M J, Verspaget, H W, Hawinkels, L J A C, Kubben, F J G M, van Duijn, W, van der Reijden, J J, Hardwick, J C H, Hommes, D W, Sier, C F M

“…Background: Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. Methods:…”
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Safety of endoscopic mucosal resection (EMR) of large non-pedunculated colorectal adenomas in the elderly by Bronsgeest, K., Huisman, J. F., Langers, A., Boonstra, J. J., Schenk, B. E., de Vos tot Nederveen Cappel, W. H., Vasen, H. F. A., Hardwick, J. C. H.

“…Background Endoscopic mucosal resection (EMR) has been proven to be safe and effective for the treatment of colorectal adenomas. However, data are limited on…”
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Rage signalling promotes intestinal tumourigenesis by Heijmans, J, Büller, N V J A, Hoff, E, Dihal, A A, van der Poll, T, van Zoelen, M A D, Bierhaus, A, Biemond, I, Hardwick, J C H, Hommes, D W, Muncan, V, van den Brink, G R

“…Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns…”
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Effect of aspirin on the Wnt/β-catenin pathway is mediated via protein phosphatase 2A by BOS, C. L, KODACH, L. L, VAN DEN BRINK, G. R, DIKS, S. H, VAN SANTEN, M. M, RICHEL, D. J, PEPPELENBOSCH, M. P, HARDWICK, J. C. H

“…Nonsteroidal anti-inflammatory drugs show chemopreventive efficacy in colon cancer, but the mechanism behind this remains unclear. Elucidating this mechanism…”
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Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis by Voorneveld, P W, Stache, V, Jacobs, R J, Smolders, E, Sitters, A I, Liesker, A, S Korkmaz, K, Lam, S M, De Miranda, N F C C, Morreau, H, Kodach, L L, Hardwick, J C H

“…Background: The expression of SMAD4, the central component of the transforming growth factor- β (TGF- β ) and bone morphogenetic protein (BMP) signalling…”
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Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract by van den Brink, G R, Hardwick, J C H, Nielsen, C, Xu, C, ten Kate, F J, Glickman, J, van Deventer, S J H, Roberts, D J, Peppelenbosch, M P

“…Background: Sonic hedgehog (Shh) is an important endodermal morphogenetic signal during the development of the vertebrate gut. It controls gastrointestinal…”
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Hedgehog Wnteraction in colorectal cancer by van den Brink, G R, Hardwick, J C H

“…Conversely, preventing inhibition of the Wnt pathway by inducible deletion of APC leads to rapid expansion of the small intestinal precursor cell compartment…”
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Endoscopic mucosal resection (EMR) versus endoscopic submucosal dissection (ESD) for resection of large distal non-pedunculated colorectal adenomas (MATILDA-trial): rationale and design of a multicenter randomized clinical trial by Backes, Y., Moons, L. M. G., van Bergeijk, J. D., Berk, L., ter Borg, F., ter Borg, P. C. J., Elias, S. G., Geesing, J. M. J., Groen, J. N., Hadithi, M., Hardwick, J. C. H., Kerkhof, M., Mangen, M. J. J., Straathof, J. W. A., Schröder, R., Schwartz, M. P., Spanier, B. W. M., de Vos tot Nederveen Cappel, W. H., Wolfhagen, F. H. J., Koch, A. D.

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Double balloon endoscopy for detection of small-bowel adenomas in familial adenomatous polyposis after pancreaticoduodenectomy according to Whipple by Langers, A M J, De Vos tot Nederveen Cappel, W H, Veenendaal, R A, Bonsing, B A, Hardwick, J C H, Vasen, H F A

“…Patients with familial adenomatous polyposis (FAP) have a 5%-10% lifetime risk of developing duodenal cancer. In severe duodenal polyposis,…”
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Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/ -catenin pathway activity by Bos, C. L., Diks, S. H., Hardwick, J. C.H., Walburg, K. V., Peppelenbosch, M. P., Richel, D. J.

“…The rising incidence and poor prognosis of colorectal cancer have aroused substantial interest in novel chemopreventive strategies. Interestingly, treatment of…”
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