Search Results - "Hardwick, J M"

Mitochondrial fission and fusion dynamics: the long and short of it by Berman, S B, Pineda, F J, Hardwick, J M

“…Maintenance of functional mitochondria requires fusion and fission of these dynamic organelles. The proteins that regulate mitochondrial dynamics are now…”
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Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects by Cheng, W-C, Teng, X, Park, H K, Tucker, C M, Dunham, M J, Hardwick, J M

“…Genetic mutations affecting mitochondrial fission and fusion proteins cause human neurological disorders, but are assumed to be well tolerated in yeast. The…”
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Conversion of Bcl-2 to a bax-like death effector by caspases by CHENG, E. H.-Y, KIRSCH, D. G, CLEM, R. J, RAVI, R, KASTAN, M. B, BEDI, A, UENO, K, HARDWICK, J. M

“…Caspases are a family of cysteine proteases implicated in the biochemical and morphological changes that occur during apoptosis (programmed cell death). The…”
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Viral versus cellular BCL-2 proteins by Hardwick, J M, Bellows, D S

“…All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2. Gamma herpesviruses are associated…”
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A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors by Duckett, C. S., Nava, V. E., Gedrich, R. W., Clem, R. J., Van Dongen, J. L., Gilfillan, M. C., Shiels, H., Hardwick, J. M., Thompson, C. B.

“…The baculovirus inhibitor of apoptosis gene, iap, can impede cell death in insect cells. Here we show that iap can also prevent cell death in mammalian cells…”
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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 by Galluzzi, L, Bravo-San Pedro, J M, Vitale, I, Aaronson, S A, Abrams, J M, Adam, D, Alnemri, E S, Andrews, D, Baehrecke, E H, Bazan, N G, Bertrand, M J, Blagosklonny, M V, Blomgren, K, Borner, C, Bredesen, D E, Brenner, C, Campanella, M, Candi, E, Cecconi, F, Chan, F K, Chandel, N S, Cheng, E H, Chipuk, J E, Cidlowski, J A, Ciechanover, A, Dawson, V L, De Laurenzi, V, De Maria, R, Debatin, K-M, Di Daniele, N, Dixit, V M, Dynlacht, B D, El-Deiry, W S, Fimia, G M, Flavell, R A, Garrido, C, Green, D R, Gronemeyer, H, Hajnoczky, G, Hardwick, J M, Hengartner, M O, Ichijo, H, Joseph, B, Jost, P J, Kaufmann, T, Kepp, O, Klionsky, D J, Knight, R A, Kumar, S, Lemasters, J J, Levine, B, Linkermann, A, Lipton, S A, Lockshin, R A, López-Otín, C, Lugli, E, Madeo, F, Malorni, W, Marine, J-C, Martin, S J, Martinou, J-C, Medema, J P, Meier, P, Melino, S, Mizushima, N, Moll, U, Muñoz-Pinedo, C, Nuñez, G, Oberst, A, Panaretakis, T, Penninger, J M, Peter, M E, Piacentini, M, Pinton, P, Prehn, J H, Puthalakath, H, Rabinovich, G A, Ravichandran, K S, Rizzuto, R, Rodrigues, C M, Rubinsztein, D C, Rudel, T, Stockwell, B R, Szabadkai, G, Tait, S W, Tang, H L, Tavernarakis, N, Tsujimoto, Y, Vanden Berghe, T, Vandenabeele, P, Villunger, A, Wagner, E F, Walczak, H, White, E, Wood, W G, Yuan, J, Zakeri, Z, Zhivotovsky, B, Melino, G, Kroemer, G

“…Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an…”
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Apoptosis in viral pathogenesis by Hardwick, J M

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Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene by Nava, V E, Cheng, E H, Veliuona, M, Zou, S, Clem, R J, Mayer, M L, Hardwick, J M

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Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence by Lewis, J, Wesselingh, S L, Griffin, D E, Hardwick, J M

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Part II. Overexpression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults by Mastrangelo, Alison J., Hardwick, J. Marie, Zou, Shifa, Betenbaugh, Michael J.

“…A number of bioreactor configurations have been developed for the manufacture of products from mammalian cell hosts. Even in the most efficient of these,…”
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Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene by Levine, Beth, Huang, Qi, Isaacs, John T, Reed, John C, Griffin, Diane E, Hardwick, J. Marie

“…Little is known about virus-host cell interactions that regulate the lytic potential of viruses during productive replication. Sindbis virus (SV), a…”
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Enhancement of suicidal DNA vaccine potency by delaying suicidal DNA-induced cell death by KIM, T. W, HUNG, C-F, JUANG, J, HE, L, HARDWICK, J. M, WU, T-C

“…DNA-based alphaviral RNA replicon vectors, also called suicidal DNA vectors, alleviate the concerns of integration or transformation related to conventional…”
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A new Epstein-Barr virus transactivator, R, induces expression of a cytoplasmic early antigen by HARDWICK, J. M, LIEBERMAN, P. M, HAYWARD, S. D

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Apoptosis as a cause of death in measles virus-infected cells by Esolen, L M, Park, S W, Hardwick, J M, Griffin, D E

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REGULATORS OF APOPTOSIS ON THE ROAD TO PERSISTENT ALPHAVIRUS INFECTION by Griffin, Diane E, Hardwick, and J. Marie

“…Alphavirus infection can trigger the host cell to activate its genetically programmed cell death pathway, leading to the morphological features of apoptosis…”
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The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions by LIEBERMAN, P. M, HARDWICK, J. M, SAMPLE, J, HAYWARD, G. S, HAYWARD, S. D

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The Epstein-Barr virus R transactivator (Rta) contains a complex, potent activation domain with properties different from those of VP16 by HARDWICK, J. M, TSE, L, APPLEGREN, N, NICHOLAS, J, VELIUONA, M. A

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Gene-dependent cell death in yeast by Teng, X, Cheng, W-C, Qi, B, Yu, T-X, Ramachandran, K, Boersma, M D, Hattier, T, Lehmann, P V, Pineda, F J, Hardwick, J M

“…Caspase-dependent apoptotic cell death has been extensively studied in cultured cells and during embryonic development, but the existence of analogous…”
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Mitochondrial factors with dual roles in death and survival by Cheng, W-C, Berman, S B, Ivanovska, I, Jonas, E A, Lee, S J, Chen, Y, Kaczmarek, L K, Pineda, F, Hardwick, J M

“…At least in mammals, we have some understanding of how caspases facilitate mitochondria-mediated cell death, but the biochemical mechanisms by which other…”
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Cyclin' on the viral path to destruction by Hardwick, J. Marie

“…Viruses are the masters of trickery. They mimic, manipulate and usurp cellular functions, but always with an interesting twist. γ-herpesvirus genomes encode an…”
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